Luliconazole microbiology: Difference between revisions
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To date, a mechanism of resistance to luliconazole has not been described. | To date, a mechanism of resistance to luliconazole has not been described. | ||
LUZU Cream, 1% has been shown to be active against most isolates of the following fungi, both in vitro and in clinical infections as described in the | LUZU Cream, 1% has been shown to be active against most isolates of the following fungi, both in vitro and in clinical infections as described in the indications and usage section: | ||
Tricophyton rubrum | *:'''[[Tricophyton]] rubrum''' | ||
Epidermophyton floccosum<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = LUZU (LULICONAZOLE) CREAM [MEDICIS PHARMACEUTICAL CORP.] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a7016010-ce43-4c09-8d21-aeb697ffed31 | publisher = | date = | accessdate = }}</ref> | |||
*:'''[[Epidermophyton]] floccosum'''<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = LUZU (LULICONAZOLE) CREAM [MEDICIS PHARMACEUTICAL CORP.] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a7016010-ce43-4c09-8d21-aeb697ffed31 | publisher = | date = | accessdate = }}</ref> | |||
==References== | ==References== | ||
Latest revision as of 15:35, 8 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]
Microbiology
Mechanism of Action
Luliconazole is an antifungal that belongs to the azole class. Although the exact mechanism of action against dermatophytes is unknown, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase. Inhibition of this enzyme’s activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol.
Mechanism of Resistance
To date, a mechanism of resistance to luliconazole has not been described.
LUZU Cream, 1% has been shown to be active against most isolates of the following fungi, both in vitro and in clinical infections as described in the indications and usage section:
- Tricophyton rubrum
- Epidermophyton floccosum[1]
References
Adapted from the FDA Package Insert.