Metronidazole overdosage: Difference between revisions
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==Overdosage== | |||
Single oral doses of metronidazole, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. | |||
Oral metronidazole has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including[[ seizures ]]and [[peripheral neuropathy]], have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day. | |||
====Treatment of Overdosage==== | |||
There is no specific antidote for metronidazole overdose; therefore, management of the patient should consist of symptomatic and supportive therapy. | |||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = FLAGYL (METRONIDAZOLE) CAPSULE [G.D. SEARLE LLC DIVISION OF PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a2883ca1-5a9a-4259-9d80-46ab67274384 | publisher = | date = | accessdate = }}</ref> | <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = FLAGYL (METRONIDAZOLE) CAPSULE [G.D. SEARLE LLC DIVISION OF PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a2883ca1-5a9a-4259-9d80-46ab67274384 | publisher = | date = | accessdate = }}</ref> | ||
Latest revision as of 00:49, 9 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
Overdosage
Single oral doses of metronidazole, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia.
Oral metronidazole has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, includingseizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.
Treatment of Overdosage
There is no specific antidote for metronidazole overdose; therefore, management of the patient should consist of symptomatic and supportive therapy. [1]
References
Adapted from the FDA Package Insert.