IMITREX injection drug interactions: Difference between revisions
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==Drug Interactions== | |||
====Ergot-Containing Drugs==== | |||
Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because these effects may be additive, use of [[ergotamine]]-containing or ergot-type medications (like [[dihydroergotamine]] or [[methysergide]]) and IMITREX Injection within 24 hours of each other is contraindicated. | |||
====Monoamine Oxidase-A Inhibitors==== | |||
MAO-A inhibitors increase systemic exposure by 2-fold. Therefore, the use of IMITREX Injection in patients receiving MAO-A inhibitors is contraindicated [see Clinical Pharmacology (12.3)]. | |||
====Other 5-HT1 Agonists==== | |||
Because their vasospastic effects may be additive, coadministration of IMITREX Injection and other 5-HT<sub>1</sub> agonists (e.g., [[triptans]]) within 24 hours of each other is contraindicated. | |||
====Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome==== | |||
Cases of serotonin syndrome have been reported during coadministration of triptans and SSRIs, or SNRIs, TCAs, and MAO inhibitors [see Warnings and Precautions (5.7)].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = IMITREX (SUMATRIPTAN SUCCINATE) INJECTION [GLAXOSMITHKLINE LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fee7d073-0b99-48f2-7985-0d8cf970894b | publisher = | date = | accessdate = }}</ref> | |||
==References== | ==References== | ||
Latest revision as of 22:14, 19 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]
Drug Interactions
Ergot-Containing Drugs
Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and IMITREX Injection within 24 hours of each other is contraindicated.
Monoamine Oxidase-A Inhibitors
MAO-A inhibitors increase systemic exposure by 2-fold. Therefore, the use of IMITREX Injection in patients receiving MAO-A inhibitors is contraindicated [see Clinical Pharmacology (12.3)].
Other 5-HT1 Agonists
Because their vasospastic effects may be additive, coadministration of IMITREX Injection and other 5-HT1 agonists (e.g., triptans) within 24 hours of each other is contraindicated.
Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome
Cases of serotonin syndrome have been reported during coadministration of triptans and SSRIs, or SNRIs, TCAs, and MAO inhibitors [see Warnings and Precautions (5.7)].[1]
References
Adapted from the FDA Package Insert.