IMITREX injection drug interactions: Difference between revisions
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====Ergot-Containing Drugs==== | ====Ergot-Containing Drugs==== | ||
Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and IMITREX Injection within 24 hours of each other is contraindicated. | Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because these effects may be additive, use of [[ergotamine]]-containing or ergot-type medications (like [[dihydroergotamine]] or [[methysergide]]) and IMITREX Injection within 24 hours of each other is contraindicated. | ||
====Monoamine Oxidase-A Inhibitors==== | ====Monoamine Oxidase-A Inhibitors==== | ||
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====Other 5-HT1 Agonists==== | ====Other 5-HT1 Agonists==== | ||
Because their vasospastic effects may be additive, coadministration of IMITREX Injection and other 5- | Because their vasospastic effects may be additive, coadministration of IMITREX Injection and other 5-HT<sub>1</sub> agonists (e.g., [[triptans]]) within 24 hours of each other is contraindicated. | ||
====Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome==== | ====Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome==== | ||
Latest revision as of 22:14, 19 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]
Drug Interactions
Ergot-Containing Drugs
Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and IMITREX Injection within 24 hours of each other is contraindicated.
Monoamine Oxidase-A Inhibitors
MAO-A inhibitors increase systemic exposure by 2-fold. Therefore, the use of IMITREX Injection in patients receiving MAO-A inhibitors is contraindicated [see Clinical Pharmacology (12.3)].
Other 5-HT1 Agonists
Because their vasospastic effects may be additive, coadministration of IMITREX Injection and other 5-HT1 agonists (e.g., triptans) within 24 hours of each other is contraindicated.
Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome
Cases of serotonin syndrome have been reported during coadministration of triptans and SSRIs, or SNRIs, TCAs, and MAO inhibitors [see Warnings and Precautions (5.7)].[1]
References
Adapted from the FDA Package Insert.