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| __NOTOC__
| | #redirect: [[Acebutolol#Adverse Reactions]] |
| {{Acebutolol}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Adverse Reactions==
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| Sectral is well tolerated in properly selected patients. Most adverse reactions have been mild, not required discontinuation of therapy, and tended to decrease as duration of treatment increases.
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| The following table shows the frequency of treatment-related side effects derived from controlled clinical trials in patients with hypertension, angina pectoris, and arrhythmia. These patients received Sectral, propranolol, or hydrochlorothiazide as monotherapy, or placebo.
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| |[[File:Acebutolol01.jpg|thumb|800px]]
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| The following selected (potentially important) side effects were seen in up to 2% of Sectral patients:
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| '''Cardiovascular''': [[hypotension]], [[bradycardia]], [[heart failure]].
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| '''Central Nervous System''': [[anxiety]], hyper/[[hypoesthesia]], [[impotence]].
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| '''Dermatological''': [[pruritus]].
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| '''Gastrointestinal''': [[vomiting]], [[abdominal pain]].
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| '''Genitourinary''': [[dysuria]], [[nocturia]].
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| '''Liver and Biliary System''': A small number of cases of liver abnormalities (increased SGOT, SGPT, LDH) have been reported in association with acebutolol therapy. In some cases increased bilirubin or alkaline phosphatase, fever, [[malaise]], [[dark urine]], [[anorexia]], [[nausea]], [[headache]], and/or other symptoms have been reported. In some of the reported cases, the symptoms and signs were confirmed by rechallenge with acebutolol. The abnormalities were reversible upon cessation of acebutolol therapy.
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| '''Musculoskeletal''': [[back pain]], [[joint pain]].
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| '''Respiratory''': [[pharyngitis]], [[wheezing]].
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| '''Special Senses''': [[conjunctivitis]], dry eye, eye pain.
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| '''Autoimmune''': In extremely rare instances, [[systemic lupus erythematosus]] has been reported.
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| The incidence of drug-related adverse effects (volunteered and solicited) according to Sectral dose is shown below. (Data from 266 [[hypertensive]] patients treated for 3 months on a constant dose.){|
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| |[[File:Acebutolol02.jpg|thumb|800px]]
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| ===Potential Adverse Events===
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| In addition, certain adverse effects not listed above have been reported with other β-blocking agents and should also be considered as potential adverse effects of Sectral.
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| '''Central Nervous System''': Reversible mental depression progressing to [[catatonia]] (an acute syndrome characterized by disorientation for time and place), short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance (neuropsychometrics).
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| '''Cardiovascular''': Intensification of AV block (see CONTRAINDICATIONS).
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| '''Allergic''': [[Erythematous rash]], fever combined with aching and sore throat, [[laryngospasm]], and [[respiratory distress]].
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| '''Hematologic''': [[Agranulocytosis]], [[nonthrombocytopenic]], and thrombocytopenic [[purpura]].
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| '''Gastrointestinal''': Mesenteric arterial thrombosis and [[ischemic colitis]].
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| '''Miscellaneous''': [[Reversible alopecia]] and [[Peyronie’s disease]]. The oculomucocutaneous syndrome associated with the β-blocker practolol has not been reported with Sectral during investigational use and extensive foreign clinical experience.
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| <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = SECTRAL (ACEBUTOLOL HYDROCHLORIDE) CAPSULE [PROMIUS PHARMA, LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7eee95bf-0452-4d6e-9712-33403768695a | publisher = | date = | accessdate = 3 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Beta blockers]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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