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| __NOTOC__
| | #REDIRECT [[Fenofibrate]] |
| {{Fenofibrate}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Drug Interactions==
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| ===Coumarin Anticoagulants===
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| Potentiation of coumarin-type anticoagulant effects has been observed with prolongation of the PT/INR.
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| Caution should be exercised when coumarin anticoagulants are given in conjunction with Antara. The dosage of the anticoagulants should be reduced to maintain the PT/INR at the desired level to prevent bleeding complications. Frequent PT/INR determinations are advisable until it has been definitely determined that the PT/INR has stabilized [see Warnings and Precautions (5.6)].
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| ===Immunosuppressants===
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| Immunosuppressants such as [[cyclosporine]] and [[tacrolimus]] can produce nephrotoxicity with decreases in creatinine clearance and because renal excretion is the primary elimination route of fibrate drugs including Antara, there is a risk that an interaction will lead to deterioration of renal function. The benefits and risks of using Antara with immunosuppressants and other potentially nephrotoxic agents should be carefully considered, and the lowest effective dose employed.
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| ===Bile-Acid Binding Resins===
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| Since bile acid binding resins may bind other drugs given concurrently, patients should take Antara at least 1 hour before or 4 to 6 hours after a bile acid binding resin to avoid impeding its absorption.
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| ===Colchicine===
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| Cases of [[myopathy]], including [[rhabdomyolysis]], have been reported with fenofibrates co-administered with [[colchicine]], and caution should be exercised when prescribing fenofibrate with [[colchicine]].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TRIGLIDE (FENOFIBRATE) TABLET [SHIONOGI INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=94a4a99b-24df-4e81-b409-5325d36647d2#nlm34067-9 | publisher = | date = | accessdate = 12 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| {{Lipid modifying agents}}
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| {{Antigout preparations}}
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| [[Category:Fibrates]] | |
| [[Category:Prodrugs]]
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| [[Category:Organochlorides]]
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| [[Category:Benzophenones]]
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| [[Category:Phenol ethers]]
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| [[Category:Carboxylate esters]]
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