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| __NOTOC__
| | #REDIRECT [[Amiloride#Nonclinical Toxicology]] |
| {{Amiloride}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Nonclinical Toxicology==
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| ===Carcinogenicity, Mutagenicity, Impairment of Fertility===
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| There was no evidence of a tumorigenic effect when amiloride HCl was administered for 92 weeks to mice at doses up to 10 mg/kg/day (25 times the maximum daily human dose). Amiloride HCl has also been administered for 104 weeks to male and female rats at doses up to 6 and 8 mg/kg/day (15 and 20 times the maximum daily dose for humans, respectively) and showed no evidence of carcinogenicity.
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| Amiloride HCl was devoid of mutagenic activity in various strains of Salmonella typhimurium with or without a mammalian liver microsomal activation system (Ames test).<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = MIDAMOR (AMILORIDE HYDROCHLORIDE) TABLET [PADDOCK LABORATORIES, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f4cde6e4-12cb-4e30-920f-5b94576b4863 | publisher = | date = | accessdate = 26 February 2014 }}</ref>
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| ==References==
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| {{reflist|2}}
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| {{Sodium channel blockers}}
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| {{Diuretics}}
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| [[Category:Potassium-sparing diuretics]]
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| [[Category:Aminopyrazines]]
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| [[Category:Guanidines]]
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| [[Category:World Health Organization essential medicines]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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