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| __NOTOC__
| | #REDIRECT [[Carvedilol#Drug Interactions]] |
| {{Carvedilol}}
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| {{CMG}}; {{AE}} {{AZ}}
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| ==Drug-Drug Interactions==
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| Since carvedilol undergoes substantial oxidative metabolism, the metabolism and pharmacokinetics of carvedilol may be affected by induction or inhibition of [[cytochrome P450]] enzymes.
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| ====Amiodarone====
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| In a pharmacokinetic trial conducted in 106 Japanese subjects with heart failure, coadministration of small loading and maintenance doses of [[amiodarone]] with carvedilol resulted in at least a 2-fold increase in the steady-state trough concentrations of S(-)-carvedilol[see Drug Interactions (7.6)].
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| ====Cimetidine====
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| In a pharmacokinetic trial conducted in 10 healthy male subjects, [[cimetidine ]](1,000 mg/day) increased the steady-state AUC of carvedilol by 30% with no change in Cmax [see Drug Interactions (7.5)].
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| ====Digoxin====
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| Following concomitant administration of carvedilol (25 mg once daily) and [[digoxin]] (0.25 mg once daily) for 14 days, steady-state AUC and trough concentrations of digoxin were increased by 14% and 16%, respectively, in 12 hypertensive subjects [see Drug Interactions (7.4)].
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| ====Glyburide====
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| In 12 healthy subjects, combined administration of carvedilol (25 mg once daily) and a single dose of [[glyburide]] did not result in a clinically relevant pharmacokinetic interaction for either compound.
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| ====Hydrochlorothiazide====
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| A single oral dose of carvedilol 25 mg did not alter the pharmacokinetics of a single oral dose of [[hydrochlorothiazide]] 25 mg in 12 subjects with hypertension. Likewise, hydrochlorothiazide had no effect on the pharmacokinetics of carvedilol.
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| ====Rifampin====
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| In a pharmacokinetic trial conducted in 8 healthy male subjects, [[rifampin]] (600 mg daily for 12 days) decreased the AUC and Cmax of carvedilol by about 70% [see Drug Interactions (7.5)].
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| ====Torsemide====
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| In a trial of 12 healthy subjects, combined oral administration of carvedilol 25 mg once daily and [[torsemide]] 5 mg once daily for 5 days did not result in any significant differences in their pharmacokinetics compared with administration of the drugs alone.
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| ====Warfarin====
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| Carvedilol (12.5 mg twice daily) did not have an effect on the steady-state [[prothrombin time]] ratios and did not alter the pharmacokinetics of R(+)- and S(-)-[[warfarin]] following concomitant administration with warfarin in 9 healthy volunteers.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = COREG (CARVEDILOL) TABLET, FILM COATED [GLAXOSMITHKLINE LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c57982f2-c7da-488a-7ea9-b9609439ac68#nlm34089-3 | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| | [[Category:Beta Blockers]] |
| | [[Category:Cardiovascular Drugs]] |
| [[Category:Drugs]] | | [[Category:Drugs]] |