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| __NOTOC__
| | #REDIRECT [[Argatroban#Drug Interactions]] |
| {{Argatroban}}
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| {{CMG}}; {{AE}} {{JH}}
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| ==Drug Interactions==
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| ====7.1 Heparin====
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| If argatroban is to be initiated after cessation of heparin therapy, allow sufficient time for heparin's effect on the [[aPTT]] to decrease prior to initiation of argatroban therapy.
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| ====7.2 Oral Anticoagulant Agents====
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| Pharmacokinetic drug-drug interactions between argatroban and [[warfarin]] (7.5 mg single oral dose) have not been demonstrated. However, the concomitant use of argatroban and [[warfarin]] (5 to 7.5 mg initial oral dose, followed by 2.5 to 6 mg/day orally for 6 to 10 days) results in prolongation of the [[prothrombin time]] (PT) and [[International Normalized Ratio]] (INR) [see Dosage and Administration (2.5) and Clinical Pharmacology (12.2)].
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| ====7.3 Aspirin/Acetaminophen====
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| No drug-drug interactions have been demonstrated between argatroban and concomitantly administered [[aspirin]] or [[acetaminophen]] [see Clinical Pharmacology (12.3)].
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| ====7.4 Thrombolytic Agents====
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| The safety and effectiveness of argatroban with thrombolytic agents have not been established [see Adverse Reactions (6.3)].
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| ====7.5 Glycoprotein IIb/IIIa Antagonists====
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| The safety and effectiveness of argatroban with glycoprotein [[IIb/IIIa]] antagonists have not been established.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ARGATROBAN INJECTION, SOLUTION [GLAXOSMITHKLINE LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9c9616c0-a299-4fd5-c8ae-79e6db453595 | publisher = | date = | accessdate = }}</ref>
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| ==Reference==
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| {{reflist}}
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| {{FDA}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Hematology]]
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| [[Category:Drugs]]
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