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| __NOTOC__
| | #REDIRECT [[Pravastatin#Adult Indications and Dosage]] |
| {{Pravastatin}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Dosage and Administration==
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| ===General Dosing Information===
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| The patient should be placed on a standard [[cholesterol]]-lowering diet before receiving PRAVACHOL and should continue on this diet during treatment with PRAVACHOL [see NCEP Treatment Guidelines for details on dietary therapy].
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| ===Adult Patients===
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| The recommended starting dose is 40 mg once daily. If a daily dose of 40 mg does not achieve desired [[cholesterol]] levels, 80 mg once daily is recommended. In patients with significant renal impairment, a starting dose of 10 mg daily is recommended. PRAVACHOL can be administered orally as a single dose at any time of the day, with or without food. Since the maximal effect of a given dose is seen within 4 weeks, periodic lipid determinations should be performed at this time and dosage adjusted according to the patient’s response to therapy and established treatment guidelines.
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| ===Pediatric Patients===
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| Children (Ages 8 to 13 Years, Inclusive)
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| The recommended dose is 20 mg once daily in children 8 to 13 years of age. Doses greater than 20 mg have not been studied in this patient population.
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| Adolescents (Ages 14 to 18 Years)
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| The recommended starting dose is 40 mg once daily in adolescents 14 to 18 years of age. Doses greater than 40 mg have not been studied in this patient population.
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| Children and adolescents treated with pravastatin should be reevaluated in adulthood and appropriate changes made to their [[cholesterol]]-lowering regimen to achieve adult goals for LDL-C [see Indications and Usage (1.2)].
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| ===Concomitant Lipid-Altering Therapy===
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| PRAVACHOL may be used with bile acid resins. When administering a bile-acid-binding resin (e.g., [[cholestyramine]], [[colestipol]]) and pravastatin, PRAVACHOL should be given either 1 hour or more before or at least 4 hours following the resin. [See Clinical Pharmacology (12.3).]
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| ===Dosage in Patients Taking Cyclosporine===
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| In patients taking immunosuppressive drugs such as [[cyclosporine]] concomitantly with pravastatin, therapy should begin with 10 mg of pravastatin sodium once-a-day at bedtime and titration to higher doses should be done with caution. Most patients treated with this combination received a maximum pravastatin sodium dose of 20 mg/day. In patients taking cyclosporine, therapy should be limited to 20 mg of pravastatin sodium once daily [see Warnings and Precautions (5.1) and Drug Interactions (7.1)].
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| ===Dosage in Patients Taking Clarithromycin===
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| In patients taking clarithromycin, therapy should be limited to 40 mg of pravastatin sodium once daily [see Drug Interactions (7.2)].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = PRAVACHOL (PRAVASTATIN SODIUM) TABLET [E.R. SQUIBB & SONS, L.L.C.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=897ad8b7-921d-eb02-a61c-3419e662a2da | publisher = | date = | accessdate = 18 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Statins]]
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| [[Category:Bristol-Myers Squibb]]
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| [[Category:Diols]]
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| [[Category:Carboxylic acids]]
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| [[Category:Carboxylate esters]]
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| [[Category:Naphthalenes]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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