|
|
| (One intermediate revision by one other user not shown) |
| Line 1: |
Line 1: |
| {{drugbox
| | #REDIRECT [[Lisinopril]] |
| | IUPAC_name = 1-[6-amino-2- (1-carboxy-3-phenyl-propyl) amino-hexanoyl]pyrrolidine- 2-carboxylic acid dihydrate
| |
| | image = Lisinopril_svg.png
| |
| | CAS_number = 83915-83-7
| |
| | ATC_prefix = C09
| |
| | ATC_suffix = AA03
| |
| | ATC_supplemental =
| |
| | PubChem = 5362119
| |
| | DrugBank = APRD00560
| |
| | C=21 | H=31 | N=3 | O=5
| |
| | molecular_weight = 405.488 g/mol
| |
| | bioavailability = approx. 25%, but wide range between individuals (6 to 60%)
| |
| | protein_bound = 0
| |
| | metabolism = None
| |
| | elimination_half-life = 12 hours
| |
| | excretion = Eliminated unchanged in Urine
| |
| | pregnancy_category = D - [[teratogenic]]
| |
| | legal_status = Rx-only
| |
| | routes_of_administration =
| |
| }}
| |
| __NOTOC__
| |
| {{CMG}}
| |
| | |
| {{Editor Join}}
| |
| | |
| | |
| ==[[Lisinopril (patient information)|For patient information, click here]]==
| |
| | |
| ==Overview==
| |
| '''Lisinopril''' (''lye-SIN-o-pril'') is a drug of the [[ACE inhibitor|angiotensin converting enzyme (ACE) inhibitor]] class that is primarily used in treatment of [[hypertension]], [[congestive heart failure]], [[myocardial infarction|heart attacks]] and also in preventing [[kidney|renal]] and [[retina]]l complications of [[diabetes mellitus|diabetes]].
| |
| | |
| Historically, lisinopril was the third ACE inhibitor, after [[captopril]] and [[enalapril]], and was introduced into therapy in the early 1990s.<ref>{{cite journal | author = Patchett A, Harris E, Tristram E, Wyvratt M, Wu M, Taub D, Peterson E, Ikeler T, ten Broeke J, Payne L, Ondeyka D, Thorsett E, Greenlee W, Lohr N, Hoffsommer R, Joshua H, Ruyle W, Rothrock J, Aster S, Maycock A, Robinson F, Hirschmann R, Sweet C, Ulm E, Gross D, Vassil T, Stone C | title = A new class of angiotensin-converting enzyme inhibitors. | journal = Nature | volume = 288 | issue = 5788 | pages = 280-3 | year = 1980 | id = PMID 6253826}}</ref> Lisinopril has a number of properties that distinguish it from other ACE inhibitors: it is [[Hydrophile|hydrophilic]], has long [[half-life]] and tissue penetration and is not [[metabolism|metabolized]] by the liver.
| |
| | |
| ==Pharmacology==
| |
| Lisinopril is the [[lysine]]-analog of enalapril. Unlike other ACE inhibitors, lisinopril is not a [[prodrug]] and is excreted unchanged in the urine. In cases of [[Effective dose|overdosage]], it can be removed from circulation by [[dialysis]].
| |
| | |
| ==Clinical use==
| |
| Its indications, contraindications and side effects are as those for all [[ACE inhibitor]]s. Its long half-life allows for once a day dosing which aids patient [[compliance (medicine)|compliance]]. The usual daily dose in all indications ranges from 2.5mg in sensitive patients to 40mg. Some patients have been treated with 80mg daily and have tolerated this high dose well. Lower dosages must be used in patients with higher grade renal impairment ([[glomerular filtration rate]] (GFR) lower than 30ml/min).
| |
| | |
| == History/brand names ==
| |
| Lisinopril was developed by [[Merck & Co.]] and is marketed worldwide as '''Prinivil®''' or '''Tensopril®''' and by [[AstraZeneca]] as '''Zestril®'''. In Australia it is marketed by [[AlphaPharm]] as '''Lisodur®'''.
| |
| | |
| == References ==
| |
| * Bussien JP, Waeber B, Nussberger J, Gomez HJ, Brunner HR. ''Once-daily lisinopril in hypertensive patients: Effect on blood pressure and the renin-angiotensin system.'' Curr Therap Res 1985;37:342-51.
| |
| * [http://www.rxlist.com/cgi/generic/lisinop.htm Lisinopril info - rx-list.com]
| |
| * Goodman & Gilman's : The pharmacological basis of therapeutics, 10th. ed., 2001
| |
| * [http://www.lisinopril.com Lisinopril.com - Lisinopril information]
| |
| | |
| ==Footnotes==
| |
| <div class="references-small"><references/></div>
| |
| | |
| | |
| {{ACE inhibitors}}
| |
| | |
| [[Category:ACE inhibitors]]
| |
| [[Category:Drugs]] | |
| | |
| [[de:Lisinopril]]
| |
| [[es:Lisinopril]]
| |
| [[hr:Lizinopril]]
| |
| [[hu:Lizinopril]]
| |
| [[nl:Lisinopril]]
| |
| [[pl:Lizynopril]]
| |
| | |
| {{WikiDoc Help Menu}}
| |
| {{WikiDoc Sources}}
| |