|
|
| Line 1: |
Line 1: |
| __NOTOC__
| | #REDIRECT [[Flecainide#Overdosage]] |
| {{Flecainide}}
| |
| {{CMG}}; {{AE}} {{SS}}
| |
| | |
| ==Overdosage==
| |
| | |
| No specific antidote has been identified for the treatment of flecainide acetate tablets overdosage. Overdoses ranging up to 8000 mg have been survived, with peak plasma flecainide concentrations as high as 5.3 mcg/mL. Untoward effects in these cases included nausea and [[vomiting]], [[convulsions]], [[hypotension]], [[bradycardia]], [[syncope]], extreme widening of the QRS complex, widening of the QT interval, widening of the PR interval, ventricular [[tachycardia]], AV nodal block, asystole, bundle branch block, [[cardiac failure]], and [[cardiac arrest]]. The spectrum of events observed in fatal cases was much the same as that seen in the non-fatal cases. Death has resulted following ingestion of as little as 1000 mg; concomitant overdose of other drugs and/or alcohol in many instances undoubtedly contributed to the fatal outcome. Treatment of overdosage should be supportive and may include the following: removal of unabsorbed drug from the gastrointestinal tract, administration of inotropic agents or cardiac stimulants such as [[dopamine]], [[dobutamine]] or [[isoproterenol]]; mechanically assisted respiration; circulatory assists such as intra-aortic balloon pumping; and transvenous pacing in the event of conduction block. Because of the long plasma half-life of flecainide (12 to 27 hours in patients receiving usual doses), and the possibility of markedly non-linear elimination kinetics at very high doses, these supportive treatments may need to be continued for extended periods of time.
| |
| | |
| [[Hemodialysis]] is not an effective means of removing flecainide from the body. Since flecainide elimination is much slower when urine is very alkaline (pH 8 or higher), theoretically, acidification of urine to promote drug excretion may be beneficial in overdose cases with very alkaline urine. There is no evidence that acidification from normal urinary pH increases excretion.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = FLECAINIDE ACETATE TABLET [APOTEX CORP.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=72595783-e6a0-6b7a-f428-9ca03d707794#nlm34084-4 | publisher = | date = | accessdate = 11 March 2014 }}</ref>
| |
| | |
| ==References==
| |
| {{Reflist}}
| |
| | |
| [[Category:Antiarrhythmic agents]]
| |
| [[Category:Piperidines]]
| |
| [[Category:Benzamides]]
| |
| [[Category:Phenol ethers]]
| |
| [[Category:Organofluorides]]
| |
| [[Category:Sodium channel blockers]]
| |
| [[Category:Cardiovascular Drugs]]
| |
| [[Category:Drugs]]
| |