|
|
| (2 intermediate revisions by one other user not shown) |
| Line 1: |
Line 1: |
| __NOTOC__
| | #REDIRECT [[Prazosin#Adverse Reactions]] |
| {{Prazosin}}
| |
| {{CMG}}; {{AE}} {{AK}}
| |
| | |
| ==ADVERSE REACTIONS==
| |
| | |
| Clinical trials were conducted on more than 900 patients. During these trials and subsequent marketing experience, the most frequent reactions associated with MINIPRESS therapy are: [[dizziness]] 10.3%, [[headache]] 7.8%, [[drowsiness]] 7.6%, lack of energy 6.9%, [[weakness]] 6.5%, [[palpitations]] 5.3%, and [[nausea]] 4.9%. In most instances, side effects have disappeared with continued therapy or have been tolerated with no decrease in dose of drug.
| |
| | |
| Less frequent adverse reactions which are reported to occur in 1–4% of patients are:
| |
| | |
| '''Gastrointestinal:''' [[vomiting]], [[diarrhea]], [[constipation]].
| |
| | |
| '''Cardiovascular:''' [[edema]], [[orthostatic hypotension]], [[dyspnea]], [[syncope]].
| |
| | |
| '''Central Nervous System:''' [[vertigo]], [[depression]], [[nervousness]].
| |
| | |
| '''Dermatologic:''' [[rash]].
| |
| | |
| '''Genitourinary:''' [[urinary frequency]].
| |
| | |
| '''EENT:''' blurred vision, reddened sclera, [[epistaxis]], [[dry mouth]], [[nasal congestion]].
| |
| | |
| In addition, fewer than 1% of patients have reported the following (in some instances, exact causal relationships have not been established):
| |
| | |
| '''Gastrointestinal:''' abdominal discomfort and/or pain, liver function abnormalities, [[pancreatitis]].
| |
| | |
| '''Cardiovascular:''' [[tachycardia]].
| |
| | |
| '''Central Nervous System:''' [[paresthesia]], [[hallucinations]].
| |
| | |
| '''Dermatologic:''' [[pruritus]], [[alopecia]], lichen [[planus]].
| |
| | |
| '''Genitourinary:''' [[incontinence]], [[impotence]], [[priapism]].
| |
| | |
| '''EENT:''' tinnitus.
| |
| | |
| '''Other:''' diaphoresis, fever, positive ANA titer, arthralgia.
| |
| | |
| Single reports of pigmentary mottling and serous [[retinopathy]], and a few reports of cataract development or disappearance have been reported. In these instances, the exact causal relationship has not been established because the baseline observations were frequently inadequate.
| |
| | |
| In more specific[[ slit-lamp]] and funduscopic studies, which included adequate baseline examinations, no drug-related abnormal ophthalmological findings have been reported.
| |
| | |
| Literature reports exist associating MINIPRESS therapy with a worsening of pre-existing [[narcolepsy]]. A causal relationship is uncertain in these cases.
| |
| | |
| In post-marketing experience, the following adverse events have been reported:
| |
| | |
| '''Autonomic Nervous System:''' [[flushing]].
| |
| | |
| '''Body As A Whole:''' [[allergic reaction]], [[asthenia]], [[malaise]], pain.
| |
| | |
| '''Cardiovascular, General:''' [[angina pectoris]], [[hypotension]].
| |
| | |
| '''Endocrine:''' [[gynecomastia]].
| |
| | |
| '''Heart Rate/Rhythm:''' [[bradycardia]].
| |
| | |
| '''Psychiatric:''' [[insomnia]].
| |
| | |
| '''Skin/Appendages:''' [[urticaria]].
| |
| | |
| '''Vascular (Extracardiac):''' [[vasculitis]].
| |
| | |
| '''Vision:''' eye pain.
| |
| | |
| '''Special Senses:''' During [[cataract]] surgery, a variant of small pupil syndrome known as Intraoperative Floppy Iris Syndrome (IFIS) has been reported in association with alpha-1 blocker therapy (see [[Prazosin precautions|PRECAUTIONS]]).
| |
| | |
| | |
| <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = MINIPRESS (PRAZOSIN HYDROCHLORIDE) CAPSULE [PFIZER LABORATORIES DIV PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=36c4da56-502e-4da1-acf7-8e81ee453dcc | publisher = | date = | accessdate = 6 March 2014 }}</ref>
| |
| | |
| | |
| | |
| | |
| ==References==
| |
| | |
| {{Reflist|2}}
| |
| | |
| [[Category:Cardiovascular Drugs]]
| |
| [[Category:Drugs]]
| |