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| __NOTOC__
| | #REDIRECT [[Quinapril#Overdosage]] |
| {{Quinapril}}
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| {{CMG}}; {{AE}} {{AM}}
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| ==Overdosage==
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| Doses of 1440 to 4280 mg/kg of quinapril cause significant lethality in mice and rats.
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| No specific information is available on the treatment of overdosage with quinapril. The most likely clinical manifestation would be symptoms attributable to severe [[hypotension]].
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| Laboratory determinations of serum levels of quinapril and its metabolites are not widely available, and such determinations have, in any event, no established role in the management of quinapril overdose.
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| No data are available to suggest physiological maneuvers (eg, maneuvers to change pH of the urine) that might accelerate elimination of quinapril and its metabolites.
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| [[Hemodialysis]] and peritoneal dialysis have little effect on the elimination of quinapril and quinaprilat. [[Angiotensin II]] could presumably serve as a specific antagonist-antidote in the setting of quinapril overdose, but angiotensin II is essentially unavailable outside of scattered research facilities. Because the hypotensive effect of quinapril is achieved through vasodilation and effective [[hypovolemia]], it is reasonable to treat quinapril overdose by infusion of normal saline solution.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ACCUPRIL (QUINAPRIL HYDROCHLORIDE) TABLET, FILM COATED [PARKE-DAVIS DIV OF PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=63cf5651-d52c-4d27-9fd4-ed9cd9724dff | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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