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| {{drugbox
| | #REDIRECT [[Quinapril#Pharmacology]] |
| | IUPAC_name = (3''S'')-2-[(2''S'')-2-<nowiki>[[</nowiki>(1''S'')-1-ethoxycarbonyl-3-phenyl-<br>propyl]amino]propanoyl]-3,4-dihydro-1''H''-isoquinoline-<br>3-carboxylic acid
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| | image = Quinapril_svg.png
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| | width = 180px
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| | CAS_number = 85441-61-8
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| | ATC_prefix = C09
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| | ATC_suffix = AA06
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| | PubChem = 54892
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| | DrugBank = APRD00523
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| | C = 25 | H = 30 | N = 2 | O = 5
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| | molecular_weight = 438.516 g/mol
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| | bioavailability =
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| | protein_bound = 97%
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| | metabolism =
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| | elimination_half-life = 2 hours
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| | pregnancy_category = D
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| | legal_status = Rx-only
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| | routes_of_administration =
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| }}
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| {{SI}}
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| {{CMG}}
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| {{Editor Join}}
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| ==[[Quinapril (patient information)|For patient information, click here]]==
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| '''Quinapril''' (marketed under the brand name '''Accupril''' by [[Pfizer]]) is an [[angiotensin-converting enzyme]] [[enzyme inhibitor|inhibitor]] ([[ACE inhibitor]]) used in the treatment of [[hypertension]] and [[congestive heart failure]].
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| ==Pharmacology==
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| Quinapril is a [[prodrug]]. It is converted to its active metabolite, quinaprilat, in the liver.
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| ==Mechanism of action==
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| {{main|ACE inhibitor}}
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| {{see also|Angiotensin|renin-angiotensin system}}
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| Quinapril inhibits [[angiotensin converting enzyme]], an enzyme which [[catalysis|catalyses]] the formation of [[angiotensin]] [[Angiotensin#Angiotensin II|II]] from its precursor, [[Angiotensin#Angiotensin I|angiotensin I]]. Angiotensin II is a powerful [[vasoconstrictor]] and increases blood pressure through a variety of mechanisms. Due to reduced angiotensin production, plasma concentrations of [[aldosterone]] are also reduced, resulting in increased excretion of [[sodium]] in the urine and increased concentrations of [[potassium]] in the blood.
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| ==Indications==
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| Quinapril is indicated for the treatment of high blood pressure ([[hypertension]]) and as adjunctive therapy in the management of [[heart failure]]. It may be used for the treatment of hypertension by itself or in combination with [[thiazide diuretic]]s, and with diuretics and [[digoxin]] for heart failure.
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| ==Contraindications==
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| <li>Pregnancy
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| <li>Impaired renal and liver function
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| <li>Patients with a history of angioedema related to previous treatment with an ACE inhibitor.
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| <li>Hypersensitive to Quinapril
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| ==Side effects==
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| [[Adverse drug reaction|Side effect]]s of quinapril include dizziness, cough, vomiting, upset stomach and [[fatigue (medical)|fatigue]].
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| ==External links==
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| *[http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a692026.html Quinapril FAQ]
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| *[http://www.accupril.com Accupril Site]
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| {{ACE inhibitors}}
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| [[Category:ACE inhibitors]]
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| [[Category:Prodrugs]]
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| [[Category:Drugs]]
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| [[fr:Quinapril]]
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| [[hu:Quinapril]]
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