|
|
| Line 1: |
Line 1: |
| __NOTOC__
| | #REDIRECT [[Losartan#Overdosage]] |
| {{Losartan}}
| |
| {{CMG}}; {{AE}} {{SS}}
| |
| | |
| ==Overdosage==
| |
| | |
| Significant lethality was observed in mice and rats after oral administration of 1000 mg/kg and 2000 mg/kg, respectively, about 44 and 170 times the maximum recommended human dose on a mg/m2 basis.
| |
| | |
| Limited data are available in regard to overdosage in humans. The most likely manifestation of overdosage would be [[hypotension]] and [[tachycardia]]; [[bradycardia]] could occur from parasympathetic (vagal) stimulation. If symptomatic [[hypotension]] should occur, supportive treatment should be instituted.
| |
| | |
| Neither losartan nor its active metabolite can be removed by [[hemodialysis]].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = COZAAR (LOSARTAN POTASSIUM) TABLET, FILM COATED [MERCK SHARP & DOHME CORP.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5ac32c20-169d-475a-fc8a-934f758d6ab0 | publisher = | date = | accessdate = 20 February 2014 }}</ref>
| |
| | |
| | |
| ==References==
| |
| | |
| {{Reflist}}
| |
| | |
| {{Angiotensin II receptor antagonists}}
| |
| | |
| [[Category:Alcohols]]
| |
| [[Category:Angiotensin II receptor antagonists]]
| |
| [[Category:Imidazoles]]
| |
| [[Category:Organochlorides]]
| |
| [[Category:Tetrazoles]]
| |
| [[Category:Biphenyls]]
| |
| [[Category:Cardiovascular Drugs]]
| |
| [[Category:Drugs]]
| |