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| __NOTOC__
| | #REDIRECT [[Diltiazem#Pharmacology]] |
| {{Diltiazem}}
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| {{CMG}}; {{AE}} {{AK}}
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| ==DESCRIPTION:==
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| Diltiazem hydrochloride injection is a calcium ion influx inhibitor (slow channel blocker or calcium channel antagonist). Chemically diltiazem hydrochloride is 1,5-benzothiazepin-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2, 3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride, (+)-cis-. The structural formula is:
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| [[image:cardizem.png]] | |
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| The molecular formula is C22H26N2O4S•HCl
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| Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It is soluble in water, methanol, and chloroform. It has a molecular weight of 450.99.
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| Diltiazem hydrochloride injection is a clear, colorless, sterile, nonpyrogenic solution. It has a pH range of 3.7 to 4.1. Diltiazem hydrochloride injection is for direct intravenous bolus injection and continuous intravenous infusion. | |
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| Each mL contains:
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| Active: 5 mg Diltiazem Hydrochloride
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| Inactives: 0.75 mg Citric Acid USP
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| 0.65 mg Sodium Citrate Dihydrate USP
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| 71.4 mg Sorbitol Solution USP
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| and, Water for Injection USP up to 1 mL
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| Sodium Hydroxide and/or Hydrochloric Acid are used for pH adjustment.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = DILTIAZEM HYDROCHLORIDE INJECTION [AKORN, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=81c5cf23-a6f8-454a-9575-d01edf49ed34 | publisher = | date = | accessdate = 5 March 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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