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| __NOTOC__
| | #REDIRECT [[Digoxin immune fab#Adult Indications and Dosage]] |
| {{Digoxin immune fab}}
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| {{CMG}}; {{AE}} {{AK}}
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| '''''For patient information about Digoxin immune fab, click [[Digoxin immune fab (patient information)|here]].'''''
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| ==INDICATIONS AND USAGE==
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| DigiFab is indicated for the treatment of patients with life-threatening or potentially life-threatening [[digoxin toxicity ]]or overdose. Although designed specifically to treat [[digoxin overdose]], a product very similar to DigiFab (Digibind) has been used successfully to treat life-threatening digitoxin overdose.7 Since human experience is limited, and the consequences of repeated exposure are unknown, DigiFab is not indicated for milder cases of digitalis toxicity.
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| ====Clinical conditions requiring administration of DigiFab include:===
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| Known suicidal or accidental consumption of fatal doses of digoxin, including ingestion of 10 mg or more of digoxin in previously healthy adults, or 4 mg for more than 0.1 mg/kg) in previously healthy children, or ingestion causing steady state serum concentrations greater than 10 ng/mL;
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| Chronic ingestions causing steady-state serum digoxin concentrations exceeding 6 ng/mL in adults or 4 ng/mL in children; and,
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| Manifestations of life-threatening toxicity due to digoxin overdose, including severe [[ventricular arrhythmias]] (such as [[ventricular tachycardia]] or [[fibrillation]]), progressive [[bradycardia]], and [[second degree heart block|second]] or [[third degree heart block]] not responsive to atropine, serum potassium levels exceeding 5.5 mEq/L in adults or 6 mEq/L in children with rapidly progressive signs and symptoms of digoxin toxicity.
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| ==References==
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| {{Reflist|2}}
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| http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6832767f-db6b-4eea-b88b-bdfc905749e1
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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