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| __NOTOC__
| | #REDIRECT [[Clopidogrel#Adult Indications and Dosage]] |
| {{Clopidogrel}}
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| {{CMG}}; {{AE}} {{JH}}
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| ==Dosage and Administration==
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| ====2.1 Acute Coronary Syndrome====
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| Plavix can be administered with or without food [see Clinical Pharmacology (12.3)].
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| For patients with non-ST-elevation ACS (UA/[[NSTEMI]]), initiate Plavix with a single 300 mg oral loading dose and then continue at 75 mg once daily. Initiate aspirin (75–325 mg once daily) and continue in combination with Plavix [see Clinical Studies (14.1)].
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| For patients with STEMI, the recommended dose of Plavix is 75 mg once daily orally, administered in combination with [[aspirin]] (75–325 mg once daily), with or without thrombolytics.
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| Plavix may be initiated with or without a loading dose [see Clinical Studies (14.1)].
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| ====2.2 Recent MI, Recent Stroke, or Established Peripheral Arterial Disease====
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| The recommended daily dose of Plavix is 75 mg once daily orally, with or without food [see Clinical Pharmacology (12.3)].
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| ====2.3 CYP2C19 Poor Metabolizers====
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| CYP2C19 poor metabolizer status is associated with diminished antiplatelet response to clopidogrel. Although a higher dose regimen in poor metabolizers increases antiplatelet response [see Clinical Pharmacology (12.5)], an appropriate dose regimen for this patient population has not been established.
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| ====2.4 Use with Proton Pump Inhibitors (PPI)====
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| Avoid using omeprazole or esomeprazole with Plavix. Omeprazole and esomeprazole significantly reduce the antiplatelet activity of Plavix. When concomitant administration of a PPI is required, consider using another acid-reducing agent with minimal or no CYP2C19 inhibitory effect on the formation of clopidogrel active metabolite [see Warnings and Precautions (5.1), Drug Interactions (7.1) and Clinical Pharmacology (12.3)].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = PLAVIX (CLOPIDOGREL BISULFATE) TABLET, FILM COATED [BRISTOL-MYERS SQUIBB/SANOFI PHARMACEUTICALS PARTNERSHIP] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=01b14603-8f29-4fa3-8d7e-9d523f802e0b | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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