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| __NOTOC__
| | #REDIRECT [[Enoxaparin#Overdosage]] |
| {{Enoxaparin}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Overdosage==
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| Accidental overdosage following administration of Lovenox may lead to hemorrhagic complications. Injected Lovenox may be largely neutralized by the slow IV injection of [[protamine sulfate]] (1%
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| solution). The dose of [[protamine sulfate]] should be equal to the dose of Lovenox injected: 1 mg [[protamine sulfate]] should be administered to neutralize 1 mg Lovenox, if enoxaparin sodium was administered in the previous 8 hours. An infusion of 0.5 mg [[protamine]] per 1 mg of enoxaparin sodium may be administered if enoxaparin sodium was administered greater than 8 hours previous to the [[protamine]] administration, or if it has been determined that a second dose of protamine is required. The second infusion of 0.5 mg [[protamine sulfate]] per 1 mg of Lovenox may be administered if the aPTT measured 2 to 4 hours after the first infusion remains prolonged.
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| If at least 12 hours have elapsed since the last enoxaparin sodium injection, protamine administration may not be required; however, even with higher doses of protamine, the aPTT may remain more prolonged than following administration of heparin. In all cases, the anti-Factor Xa activity is never completely neutralized (maximum about 60%). Particular care should be taken to avoid overdosage with [[protamine sulfate]]. Administration of [[protamine sulfate]] can cause severe hypotensive and anaphylactoid reactions. Because fatal reactions, often resembling anaphylaxis, have been reported with [[protamine sulfate]], it should be given only when resuscitation techniques and treatment of anaphylactic shock are readily available. For additional information consult the labeling of [[protamine sulfate]] injection products.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = LOVENOX (ENOXAPARIN SODIUM) INJECTION [SANOFI-AVENTIS U.S. LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5017a927-2a24-4f27-89f9-27c805bf7d59 | publisher = | date = | accessdate = 6 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antiplatelet drugs]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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