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| __NOTOC__
| | #REDIRECT [[Disopyramide#Pharmacology]] |
| {{Disopyramide}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Description==
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| Norpace (disopyramide phosphate) is an antiarrhythmic drug available for oral administration in immediate-release and controlled-release capsules containing 100 mg or 150 mg of disopyramide base, present as the phosphate. The base content of the phosphate salt is 77.6%. The structural formula of Norpace is:
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| |[[File:Disopyramide04.jpg|thumb|800px]]
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| {|
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| |[[File:Disopyramide05.jpg|thumb|800px]]
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| Norpace is freely soluble in water, and the free base (pKa 10.4) has an aqueous solubility of 1 mg/ml. The chloroform:water partition coefficient of the base is 3.1 at pH 7.2.
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| Norpace is a racemic mixture of d- and l- isomers. This drug is not chemically related to other antiarrhythmic drugs.
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| Norpace CR (controlled-release) capsules are designed to afford a gradual and consistent release of disopyramide. Thus, for maintenance therapy, Norpace CR provides the benefit of less-frequent dosing (every 12 hours) as compared with the every-6-hour dosage schedule of immediate-release Norpace capsules.
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| Inactive ingredients of Norpace include corn starch, edible ink, FD&C Red No. 3, FD&C Yellow No. 6, gelatin, lactose, talc, and titanium dioxide; the 150-mg capsule also contains FD&C Blue No. 1.
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| Inactive ingredients of Norpace CR include corn starch, D&C Yellow No. 10, edible ink, ethylcellulose, FD&C Blue No. 1, gelatin, shellac, sucrose, talc, and titanium dioxide; the 150-mg capsule also contains FD&C Red No. 3 and FD&C Yellow No. 6.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = NORPACE (DISOPYRAMIDE PHOSPHATE) CAPSULE, GELATIN COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e2aa1642-d262-4520-bc6a-9fd3ad795677 | publisher = | date = | accessdate = 3 March 2014 }}</ref>
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| ==References==
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| {{Reflist}}
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| [[Category:Pyridines]]
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| [[Category:Sodium channel blockers]]
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| [[Category:Amides]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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