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| __NOTOC__
| | #REDIRECT [[Guanfacine#Overdosage]] |
| {{Guanfacine}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Overdosage==
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| ===Signs and Symptoms===
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| [[Drowsiness]], [[lethargy]], [[bradycardia]] and [[hypotension]] have been observed following overdose with guanfacine.
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| A 25-year-old female intentionally ingested 60 mg. She presented with severe [[drowsiness]] and [[bradycardia]] of 45 beats/minute. Gastric lavage was performed and an infusion of [[isoproterenol]] (0.8 mg in 12 hours) was administered. She recovered quickly and without sequelae.
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| A 28-year-old female who ingested 30 - 40 mg developed only lethargy, was treated with activated [[charcoal]] and a [[cathartic]], was monitored for 24 hours, and was discharged in good health.
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| A 2-year-old male weighing 12 kg who ingested up to 4 mg of guanfacine developed lethargy. Gastric lavage (followed by activated charcoal and sorbitol slurry via NG tube) removed some tablet fragments within 2 hours after ingestion, and vital signs were normal.
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| During 24-hour observation in ICU, systolic pressure was 58 and heart rate 70 at 16 hours post-ingestion. No intervention was required, and child was discharged fully recovered the next day.
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| ===Treatment of Overdosage===
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| Gastric lavage and supportive therapy as appropriate. Guanfacine is not dialyzable in clinically significant amounts (2.4%).<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TENEX (GUANFACINE HYDROCHLORIDE) TABLET [PROMIUS PHARMA, LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=886e050c-dd22-4f35-ac3b-243f091125c3#nlm34067-9 | publisher = | date = | accessdate = 25 February 2014 }}</ref>
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| ==References==
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| {{reflist|2}}
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| {{Antihypertensives and diuretics}}
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| {{Antihyperkinetics}}
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| {{Adrenergics}}
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| [[Category:Antihypertensive agents]]
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| [[Category:Guanidines]]
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| [[Category:Alpha-adrenergic agonists]]
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| [[Category:Acetamides]]
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| [[Category:Organochlorides]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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