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| __NOTOC__
| | #REDIRECT [[Metoprolol succinate#Adult Indications and Dosage]] |
| {{Metoprolol}}
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| {{CMG}}
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| ===Hypertension===
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| TOPROL-XL is indicated for the treatment of [[hypertension]], to lower [[blood pressure]]. Lowering [[blood pressure]] lowers the risk of fatal and non-fatal cardiovascular events, primarily [[stroke]]s and [[myocardial infarction]]s. These benefits have been seen in controlled trials of [[antihypertensive]] drugs from a wide variety of pharmacologic classes including metoprolol.
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| Control of high [[blood pressure]] should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, [[diabetes]] management, [[antithrombotic]] therapy, [[smoking]] cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve [[blood pressure]] goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).
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| Numerous [[antihypertensive drug]]s, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is [[blood pressure]] reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of [[stroke]], but reductions in [[myocardial infarction]] and [[cardiovascular]] [[mortality]] also have been seen regularly.
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| Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.
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| Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (eg, on angina, heart failure, or diabetic kidney disease). These considerations may guide selection of therapy.
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| TOPROL-XL may be administered with other antihypertensive agents.
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| ===Angina Pectoris===
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| TOPROL-XL is indicated in the long-term treatment of angina pectoris, to reduce angina attacks and to improve exercise tolerance.
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| ===Heart Failure===
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| TOPROL-XL is indicated for the treatment of stable, symptomatic (NYHA Class II or III) heart failure of ischemic, hypertensive, or cardiomyopathic origin. It was studied in patients already receiving ACE inhibitors, diuretics, and, in the majority of cases, digitalis. In this population, TOPROL-XL decreased the rate of mortality plus hospitalization, largely through a reduction in cardiovascular mortality and hospitalizations for heart failure.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TOPROL XL (METOPROLOL SUCCINATE) TABLET, EXTENDED RELEASE [BRYANT RANCH PREPACK] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=01038198-b4f0-41f3-9a9c-5c84e5a0d3b9 | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| [[Category:Beta blockers]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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