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| __NOTOC__
| | #REDIRECT [[Metoprolol succinate#Adult Indications and Dosage]] |
| {{Metoprolol}}
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| {{CMG}}
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| ===Hypertension===
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| TOPROL-XL is indicated for the treatment of [[hypertension]], to lower [[blood pressure]]. Lowering [[blood pressure]] lowers the risk of fatal and non-fatal cardiovascular events, primarily [[stroke]]s and [[myocardial infarction]]s. These benefits have been seen in controlled trials of [[antihypertensive]] drugs from a wide variety of pharmacologic classes including metoprolol.
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| Control of high [[blood pressure]] should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, [[diabetes]] management, [[antithrombotic]] therapy, [[smoking]] cessation, [[exercise]], and limited [[sodium]] intake. Many patients will require more than 1 drug to achieve [[blood pressure]] goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).
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| Numerous [[antihypertensive drug]]s, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce [[cardiovascular]] [[morbidity]] and [[mortality]], and it can be concluded that it is [[blood pressure]] reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of [[stroke]], but reductions in [[myocardial infarction]] and [[cardiovascular]] [[mortality]] also have been seen regularly.
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| Elevated [[SBP|systolic]] or [[DBP|diastolic pressure]] causes increased [[cardiovascular]] risk, and the absolute risk increase per mmHg is greater at higher [[blood pressure]]s, so that even modest reductions of severe [[hypertension]] can provide substantial benefit. Relative risk reduction from [[blood pressure]] reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their [[hypertension]] (for example, patients with [[diabetes]] or [[hyperlipidemia]]), and such patients would be expected to benefit from more aggressive treatment to a lower [[blood pressure]] goal.
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| Some [[antihypertensive drug]]s have smaller [[blood pressure]] effects (as monotherapy) in black patients, and many [[antihypertensive drug]]s have additional approved indications and effects (eg, on [[angina]], [[heart failure]], or [[diabetic nephropathy|diabetic kidney disease]]). These considerations may guide selection of therapy.
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| TOPROL-XL may be administered with other [[antihypertensive agent]]s.
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| ===Angina Pectoris===
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| TOPROL-XL is indicated in the long-term treatment of [[angina pectoris]], to reduce [[angina]] attacks and to improve exercise tolerance.
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| ===Heart Failure===
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| TOPROL-XL is indicated for the treatment of stable, symptomatic ([[NYHA]] Class II or III) [[heart failure]] of [[ischemia|ischemic]], [[hypertensive]], or [[cardiomyopathy|cardiomyopathic]] origin. It was studied in patients already receiving [[ACE inhibitor]]s, [[diuretic]]s, and, in the majority of cases, [[digitalis]]. In this population, TOPROL-XL decreased the rate of [[mortality]] plus hospitalization, largely through a reduction in [[cardiovascular]] [[mortality]] and hospitalizations for [[heart failure]].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TOPROL XL (METOPROLOL SUCCINATE) TABLET, EXTENDED RELEASE [BRYANT RANCH PREPACK] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=01038198-b4f0-41f3-9a9c-5c84e5a0d3b9 | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| [[Category:Antianginals]]
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| [[Category:Antiarrhythmic agents]]
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| [[Category:Antihypertensive agents]]
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| [[Category:Antimigraine drugs]]
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| [[Category:Beta blockers]]
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| [[Category:Cardiovascular Drugs]]
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