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| __NOTOC__
| | #REDIRECT [[Metoprolol succinate#Nonclinical Toxicology]] |
| {{Metoprolol}}
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| {{CMG}}
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| ====Carcinogenesis, Mutagenesis, Impairment of Fertility====
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| Long-term studies in animals have been conducted to evaluate the carcinogenic potential of metoprolol tartrate. In 2-year studies in rats at three oral dosage levels of up to 800 mg/kg/day (41 times, on a mg/m<sup>2</sup> basis, the daily dose of 200 mg for a 60-kg patient), there was no increase in the development of spontaneously occurring benign or malignant [[neoplasm]]s of any type. The only histologic changes that appeared to be drug related were an increased incidence of generally mild focal accumulation of [[foam cell|foamy macrophages]] in pulmonary [[alveoli]] and a slight increase in biliary [[hyperplasia]]. In a 21-month study in Swiss albino mice at three oral dosage levels of up to 750 mg/kg/day (18 times, on a mg/m<sup>2</sup> basis, the daily dose of 200 mg for a 60-kg patient), benign lung tumors (small [[adenoma]]s) occurred more frequently in female mice receiving the highest dose than in untreated control animals. There was no increase in malignant or total (benign plus malignant) lung [[tumor]]s, nor in the overall incidence of tumors or malignant tumors. This 21-month study was repeated in CD-1 mice, and no statistically or biologically significant differences were observed between treated and control mice of either sex for any type of tumor.
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| All genotoxicity tests performed on metoprolol tartrate (a dominant lethal study in mice, [[chromosome]] studies in [[somatic cell]]s, a [[Salmonella]]/mammalian-[[microsome]] mutagenicity test, and a nucleus anomaly test in somatic [[interphase]] nuclei) and metoprolol succinate (a [[Salmonella]]/mammalian-[[microsome]] mutagenicity test) were negative.
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| No evidence of impaired fertility due to metoprolol tartrate was observed in a study performed in rats at doses up to 22 times, on a mg/m<sup>2</sup> basis, the daily dose of 200 mg in a 60- kg patient.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = TOPROL XL (METOPROLOL SUCCINATE) TABLET, EXTENDED RELEASE [BRYANT RANCH PREPACK] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=01038198-b4f0-41f3-9a9c-5c84e5a0d3b9 | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| [[Category:Beta blockers]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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