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__NOTOC__
#REDIRECT [[Metoprolol tartrate#Overdosage]]
{{Metoprolol}}
{{CMG}}; {{AE}} {{AZ}}
 
==Overdosage==
 
====Acute Toxicity====
 
Several cases of overdosage have been reported, some leading to death.
 
Oral LD 50’s (mg/kg): mice, 1158-2460; rats, 3090-4670.
 
Signs and Symptoms
 
Potential signs and symptoms associated with overdosage with Lopressor are bradycardia, hypotension, bronchospasm, myocardial infarction, cardiac failure and death.
 
====Management====
 
There is '''no specific antidote.'''
 
In general, patients with acute or recent myocardial infarction may be more hemodynamically unstable than other patients and should be treated accordingly (see WARNINGS, Myocardial Infarction).
 
On the basis of the pharmacologic actions of Lopressor, the following general measures should be employed:
 
'''Elimination of the Drug''': Gastric lavage should be performed.
Other clinical manifestations of overdose should be managed symptomatically based on modern methods of intensive care.
 
'''Hypotension''': Administer a vasopressor, e.g., levarterenol or dopamine.
 
'''Bronchospasm''': Administer a beta2-stimulating agent and/or a theophylline derivative.
 
'''Cardiac Failure''': Administer digitalis glycoside and diuretic. In shock resulting from inadequate cardiac contractility, consider administration of dobutamine, isoproterenol or glucagon.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = LOPRESSOR (METOPROLOL TARTRATE) TABLET [NOVARTIS PHARMACEUTICALS CORPORATION] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bb05420c-fd24-4672-9f62-fdd313819287 | publisher =  | date =  | accessdate = }}</ref>
==References==
{{Reflist}}
 
{{FDA}}
 
[[Category:Drugs]]

Latest revision as of 03:49, 22 July 2014