Lopressor/overdosage: Difference between revisions

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Metoprolol tartrate#Overdosage

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+#REDIRECT [[Metoprolol tartrate#Overdosage]]
-{{Metoprolol}}
-{{CMG}}
-==Overdosage==
-====Acute Toxicity====
-Several cases of overdosage have been reported, some leading to death.
-Oral LD 50’s (mg/kg): mice, 1158-2460; rats, 3090-4670.
-Signs and Symptoms
-Potential signs and symptoms associated with overdosage with Lopressor are bradycardia, hypotension, bronchospasm, myocardial infarction, cardiac failure and death.
-====Management====
-There is no specific antidote.
-In general, patients with acute or recent myocardial infarction may be more hemodynamically unstable than other patients and should be treated accordingly (see WARNINGS, Myocardial Infarction).
-On the basis of the pharmacologic actions of Lopressor, the following general measures should be employed:
-Elimination of the Drug: Gastric lavage should be performed.
-Other clinical manifestations of overdose should be managed symptomatically based on modern methods of intensive care.
-Hypotension: Administer a vasopressor, e.g., levarterenol or dopamine.
-Bronchospasm: Administer a beta2-stimulating agent and/or a theophylline derivative.
-Cardiac Failure: Administer digitalis glycoside and diuretic. In shock resulting from inadequate cardiac contractility, consider administration of dobutamine, isoproterenol or glucagon.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = LOPRESSOR (METOPROLOL TARTRATE) TABLET [NOVARTIS PHARMACEUTICALS CORPORATION] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bb05420c-fd24-4672-9f62-fdd313819287 | publisher =  | date =  | accessdate = }}</ref>
-==References==
-{{Reflist}}
-{{FDA}}
-[[Category:Drugs]]
-[[Category:Cardiovascular Drugs]]
-[[Category:Beta blockers]]

Lopressor/overdosage: Difference between revisions

Latest revision as of 03:49, 22 July 2014

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