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__NOTOC__
#REDIRECT [[Metoprolol tartrate#Overdosage]]
{{Metoprolol}}
{{CMG}}
 
==Overdosage==
 
====Acute Toxicity====
 
Several cases of overdosage have been reported, some leading to death.
 
Oral LD 50’s (mg/kg): mice, 1158-2460; rats, 3090-4670.
 
======Signs and Symptoms======
 
Potential signs and symptoms associated with overdosage with Lopressor are [[bradycardia]], [[hypotension]], [[bronchospasm]], [[myocardial infarction]], [[cardiac failure]] and death.
 
====Management====
 
There is no specific antidote.
 
In general, patients with acute or recent [[myocardial infarction]] may be more hemodynamically unstable than other patients and should be treated accordingly (see WARNINGS, Myocardial Infarction).
 
On the basis of the pharmacologic actions of Lopressor, the following general measures should be employed:
 
Elimination of the Drug: Gastric lavage should be performed.
 
Other clinical manifestations of overdose should be managed symptomatically based on modern methods of intensive care.
 
<u>'''Hypotension'''</u>: Administer a [[vasopressor]], e.g., [[levarterenol]] or [[dopamine]].
 
<u>'''Bronchospasm'''</u>: Administer a [[beta2]]-stimulating agent and/or a [[theophylline]] derivative.
 
<u>'''Cardiac Failure'''</u>: Administer [[digitalis glycoside]] and [[diuretic]]. In shock resulting from inadequate cardiac contractility, consider administration of [[dobutamine]], [[isoproterenol]] or [[glucagon]].<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = LOPRESSOR (METOPROLOL TARTRATE) TABLET [NOVARTIS PHARMACEUTICALS CORPORATION] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bb05420c-fd24-4672-9f62-fdd313819287 | publisher =  | date =  | accessdate = }}</ref>
 
==References==
 
{{Reflist}}
 
{{FDA}}
 
[[Category:Beta blockers]]
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]

Latest revision as of 03:49, 22 July 2014

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