Lopressor/pregnancy category: Difference between revisions

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__NOTOC__
#REDIRECT [[Metoprolol tartrate#Use in Specific Populations]]
{{Lopressor}}
{{CMG}}; {{AE}} {{SS}}
 
==pregnancy category==
 
===Pregnancy Category C===
Upon confirming the diagnosis of pregnancy, women should immediately inform the doctor.
 
Lopressor has been shown to increase postimplantation loss and decrease neonatal survival in rats at doses up to 11 times the maximum daily human dose of 450 mg, when based on surface area. Distribution studies in mice confirm exposure of the fetus when Lopressor is administered to the pregnant animal. These limited animal studies do not indicate direct or indirect harmful effects with respect to teratogenicity (see Carcinogenesis, Mutagenesis, Impairment of Fertility).
 
There are no adequate and well-controlled studies in pregnant women. The amount of data on the use of metoprolol in pregnant women is limited. The risk to the fetus/mother is unknown. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = LOPRESSOR (METOPROLOL TARTRATE) INJECTION, SOLUTION [NOVARTIS PHARMACEUTICALS CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6640cc61-edee-4808-a26f-cbc2c0b7af86 | publisher =  | date =  | accessdate = 18 March 2014 }}</ref><ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = LOPRESSOR (METOPROLOL TARTRATE) TABLET [NOVARTIS PHARMACEUTICALS CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bb05420c-fd24-4672-9f62-fdd313819287#nlm42232-9 | publisher =  | date =  | accessdate = 18 March 2014 }}</ref>
 
==References==
{{Reflist}}
 
[[Category:beta-Adrenergic Blocker]]
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]

Latest revision as of 03:50, 22 July 2014

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