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| __NOTOC__
| | #REDIRECT [[Atorvastatin#Adult Indications and Dosage]] |
| {{Atorvastatin}}
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| {{CMG}}; {{AE}} {{PB}}
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| ==Indications and Usage==
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| Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to [[hypercholesterolemia]]. Drug therapy is recommended as an adjunct to diet when the response to a diet restricted in saturated fat and [[cholesterol]] and other nonpharmacologic measures alone has been inadequate. In patients with [[CHD]] or multiple risk factors for CHD, LIPITOR can be started simultaneously with diet.
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| ====Prevention of Cardiovascular Disease====
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| In adult patients without clinically evident coronary heart disease, but with multiple risk factors for coronary heart disease such as age, [[smoking]], [[hypertension]], low [[HDL]]-C, or a family history of early coronary heart disease, LIPITOR is indicated to:
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| * Reduce the risk of [[myocardial infarction]]
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| * Reduce the risk of [[stroke]]
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| * Reduce the risk for [[revascularization]] procedures and [[angina]]
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| In patients with type 2 diabetes, and without clinically evident coronary heart disease, but with multiple risk factors for coronary heart disease such as [[retinopathy]], [[albuminuria]], [[smoking]], or [[hypertension]], LIPITOR is indicated to:
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| * Reduce the risk of [[myocardial infarction]]
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| * Reduce the risk of [[stroke]]
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| In patients with clinically evident coronary heart disease, LIPITOR is indicated to:
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| * Reduce the risk of non-fatal [[myocardial infarction]]
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| * Reduce the risk of fatal and non-fatal [[stroke]]
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| * Reduce the risk for [[revascularization]] procedures
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| * Reduce the risk of hospitalization for [[CHF]]
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| * Reduce the risk of [[angina]]
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| ====Hyperlipidemia====
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| LIPITOR is indicated:
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| * As an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels and to increase HDL-C in patients with primary [[hypercholesterolemia]] (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson Types IIa and IIb);
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| * As an adjunct to diet for the treatment of patients with elevated serum TG levels (Fredrickson Type IV);
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| * For the treatment of patients with primary dysbetalipoproteinemia (Fredrickson Type III) who do not respond adequately to diet;
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| * To reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable;
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| * As an adjunct to diet to reduce total-C, LDL-C, and apo B levels in boys and postmenarchal girls, 10 to 17 years of age, with heterozygous familial hypercholesterolemia if after an adequate trial of diet therapy the following findings are present:
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| : LDL-C remains ≥ 190 mg/dL or
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| : LDL-C remains ≥ 160 mg/dL and:
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| :: a) there is a positive family history of premature cardiovascular disease
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| :: b) or two or more other CVD risk factors are present in the pediatric patient
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| ====Limitations of Use====
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| LIPITOR has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson Types I and V).
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| ==References==
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| {{Reflist}}
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