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! style="background: #4479BA; width: 500px;" | {{fontcolor|#FFF|Significance}} | ! style="background: #4479BA; width: 500px;" | {{fontcolor|#FFF|Significance}} | ||
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| style="padding: 5px 5px; background: #DCDCDC;" | ''' | | style="padding: 5px 5px; background: #DCDCDC;" | '''Anti-HDV IgG antibody''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Positive in persons exposed to HDV | |||
*Persists, even after viral clearance | |||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;" | ''' | | style="padding: 5px 5px; background: #DCDCDC;" | '''Anti-HDV IgM antibody''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Positive in acute infection | |||
*Negative in past infection | |||
*Persists in many patients with chronic infection | |||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;" | ''' | | style="padding: 5px 5px; background: #DCDCDC;" | '''HDV RNA''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
'''Qualitative''' | |||
:*Marker of HDV replication | |||
:*Positive in chronic infection | |||
:*Negative in spontaneous or treatment-induced viral clearance | |||
'''Quantitative''' | |||
:*Useful in monitoring or predicting treatment response | |||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;" | ''' | | style="padding: 5px 5px; background: #DCDCDC;" | '''HBsAg''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
'''Qualitative''' | |||
:*Must be positive for HDV infectivity | |||
'''Quantitative''' | |||
:*Positively correlated with HDV RNA | |||
:*Falling titer signals HBsAg loss, and hence HDV clearance | |||
:*Useful in monitoring or predicting treatment response | |||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;" | ''' | | style="padding: 5px 5px; background: #DCDCDC;" | '''HBeAg''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Negative in an estimated 85% of patients | |||
*Associated with detectable anti-HBe | |||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;" | '''HBV DNA | | style="padding: 5px 5px; background: #DCDCDC;" | '''HBV DNA''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
'''Quantitative''' | |||
:*Suppressed by HDV | |||
:*Negative or low levels in most patients | |||
:*May be increased in patients with detectable HBeAg | |||
:*Can reactivate after spontaneous or treatment-induced clearance of HDV | |||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;" | ''' | | style="padding: 5px 5px; background: #DCDCDC;" | '''ALT''' | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Increased in most patients | |||
*Does not correlate well with degree of histological liver damage | |||
|- | |- | ||
|} | |} |
Latest revision as of 21:30, 6 August 2014
Diagnostic Markers | Significance |
---|---|
Anti-HDV IgG antibody |
|
Anti-HDV IgM antibody |
|
HDV RNA |
Qualitative
Quantitative
|
HBsAg |
Qualitative
Quantitative
|
HBeAg |
|
HBV DNA |
Quantitative
|
ALT |
|