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==Causes==  
==Causes==  
 
===Common Causes ===
=== Most Common Causes ===
 
* Anticoagulation therapy
* Anticoagulation therapy
* Hepatopathies
* Hepatopathies
Line 22: Line 20:
* [[Vitamin K]] deficiency
* [[Vitamin K]] deficiency


=== Causes of Hemorrhagic Diathesis In Alphabetical Order. <ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>===
===Causes by Organ System===
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Anaphylactic shock]],  [[Bacterial endocarditis]],  [[Cyanotic cardiac vitium]],  [[Diffuse intravascular coagulation]],  [[Large vascular prostheses]],  [[Marfan's syndrome]],  [[Myocardial infarction]],  [[Vascular hemostatic disorder]],  [[Vascular purpura]],  [[Vasculitis]],
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
|bgcolor="Beige"| [[Bothrop venom]],  [[Rattlesnake venom]],  [[Viper venom]]
|-
|-bgcolor="LightSteelBlue"
| '''Dental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| [[Henoch-schonlein purpura]],  [[Measles]],  [[Nonthrombocytopenic purpura]],  [[Osler's disease]],  [[Scurvy]],  [[Senile-atrophic senilis]]
|-
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Anti-aggregation with aspirin]],  [[Anticoagulation inhibitors]],  [[Cobimetinib]],  [[Epoprostenol]],  [[Factor viii inhibitors]],  [[Propylthiouracil]],  [[Ramucirumab]],  [[Therapy with cholestyramin]],  [[Warfarin]]
|-
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| [[Amyloidosis]],  [[Chronic hypercortisolism]],  [[Cushing's syndrome]],  [[Hermansky-pudlak syndrome]],
|-
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| [[Acute pancreatitis]],  [[Biliary cirrhosis]],  [[Cirrhosis]],  [[Faulty intestinal flora]],  [[Liver failure]],  [[Severe gastrointestinal bleeding]],  [[Severe hepatopathy]],  [[Splenomegaly with portal hypertension]]
|-
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"| [[Ehlers-danlos syndrome]],  [[Osteogenesis imperfecta]],  [[Pseudoxanthoma elasticum]],  [[Wiskott-aldrich syndrome]]
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| [[Ehlers-danlos syndrome]],  [[Osteogenesis imperfecta]],  [[Pseudoxanthoma elasticum]],  [[Wiskott-aldrich syndrome]]
|-
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| [[Fibrinolysis therapy]],  [[Fibrinolytic fission products]],  [[Graft vs. host disease]],  [[Grey platelet syndrome]],  [[Large operations]],  [[Large vascular prostheses]],
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| [[Bacterial endocarditis]],  [[Bacterial meningitis]],  [[Cephalosporins]],  [[Dengue hemorrhagic fever]],  [[Dengue shock syndrome]],  [[Diptheria]],  [[Influenza]],  [[Leptospirosis]],  [[Malaria]],  [[Measles]],  [[Rickettsia]],  [[Scarlet fever]],  [[Scurvy]],  [[Sepsis]],  [[Syphilis]],  [[Toxoplasmosis]],  [[Varicella]]
|-
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| [[Myelodysplasia]],  [[Myeloproliferative syndrome]]
|-
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
|bgcolor="Beige"| [[Bacterial meningitis]],  [[Cranio cerebral trauma]],  [[Large aneurysms]], [[Osler's disease]]
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| [[Avitaminosis c]], [[Cirrhosis]], [[Dietary deficiencies]],  [[Malabsorption]], [[Parenteral nutrition]], [[Vitamin k deficiency]]
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| [[Amniotic fluid embolism]],  [[Intrauterine embryo death]],  [[Parenteral nutrition]],  [[Premature placenta ablation]],  [[Septic abortion]]
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| [[Carcinomas]], [[Leukemia]], [[Myelodysplasia]], [[Myeloproliferative syndrome]]
|-
|-bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
|bgcolor="Beige"|
|-
|-bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| [[Anaphylactic shock]]
|-
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
|bgcolor="Beige"| [[Lactic acidosis]], [[Renal failure]], [[Uremia]]
|-
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| [[Cystic fibrosis]],  [[Dysfibrinogenemia]]
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| [[Syphilis]]
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| [[Burns]],  [[Cranio cerebral trauma]],  [[Hypothermia]],  [[Intrauterine embryo death]]
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| [[Uremia]]
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying causes
|-
|}


* Activated blood clotting factors
===Causes In Alphabetical Order. <ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>===
* [[Acute leukemias]]
{{columns-list|
* Acute [[Pancreatitis]]
*[[Activated blood clotting factors]]
* [[Afibrinogenemia]]
*[[Acute pancreatitis]]
* [[Alcoholism]]
*[[Afibrinogenemia]]
* Amniotic fluid embolism
*[[Amniotic fluid embolism]]
* [[Amyloidosis]]
*[[Amyloidosis]]
* Anaphylactic shock
*[[Anaphylactic shock]]
* Anti-aggregation with aspirin
*[[Anti-aggregation with aspirin]]
* Aspirin-like defect
*[[Anticoagulation inhibitors]]
* Avitaminosis C
*[[Antiphospholipid syndrome]]
* [[Bacterial Endocarditis]]
*[[Avitaminosis c]]
* [[Bacterial Meningitis]]
*[[Bacterial endocarditis]]
* [[Bernard-Soulier Syndrome]] ([[BSS]])
*[[Bacterial meningitis]]
* [[Biliary Cirrhosis]]
*[[Bernard-soulier syndrome ]]
* [[Burns]]
*[[Biliary cirrhosis]]
* [[Carcinoma]]s
*[[Bothrop venom]]
* [[Cephalosporins]]
*[[Burns]]
* [[Chediak-Higashi Syndrome]]
*[[Carcinomas]]
* Chronic hypercortisolism
*[[Cephalosporins]]
* [[Cirrhosis]]
*[[Chediak-higashi syndrome]]
* Coagulation factor deficiency
*[[Chronic hypercortisolism]]
* Consumption coagulopathy
*[[Cirrhosis]]
* Cranio cerebral trauma
*[[Coagulation factor deficiency]]
* [[Cryoglobulinemia]]
*[[Cobimetinib]]
* Cyanotic cardiac vitium
*[[Congenital disorder of glycosylation type 1k]]
* Dietary deficiencies
*[[Consumption coagulopathy]]
* [[Diffuse Intravascular Coagulation]]
*[[Cranio cerebral trauma]]
* [[Diptheria]]
*[[Cryoglobulinemia]]
* [[Disseminated Intravascular Coagulation]] (DIC)
*[[Cushing's syndrome]]
* [[Drug]]s
*[[Cyanotic cardiac vitium]]
* Dysfibrinogenemia
*[[Cystic fibrosis]]
* [[Ehlers-Danlos Syndrome]]
*[[Dengue hemorrhagic fever]]
* Faulty intestinal flora
*[[Dengue shock syndrome]]
* Fibrinogenolysis
*[[Dextran plasma volume expander]]
* Fibrinolytic fission products
*[[Dietary deficiencies]]
* Fibrinolysis therapy
*[[Diffuse intravascular coagulation]]
* [[Folic acid deficiency]]
*[[Diptheria]]
* [[Glanzmann thrombasthenia]]
*[[Disseminated intravascular coagulation]]
* [[Graft vs. Host Disease]]
*[[Dysfibrinogenemia]]
* [[Grey platelet syndrome]]
*[[Ehlers-danlos syndrome]]
* Hegglin's anomaly
*[[Epoprostenol]]
* [[HELLP Syndrome]] ('''H'''emolysis, '''E'''levated '''L'''iver enzymes, '''L'''ow '''P'''latelet count)
*[[Factor viii inhibitors]]
* [[Hemophilia]] A & B
*[[Faulty intestinal flora]]
* [[Henoch-Schonlein purpura]]
*[[Fibrinogenolysis]]
* [[Hereditary hemorrhagic telangiectasia]]
*[[Fibrinolysis therapy]]
* [[Hermansky-Pudlak Syndrome]]
*[[Fibrinolytic fission products]]
* Hyperglobulinemia
*[[Folic acid deficiency]]
* [[Ddx:Hypothermia|Hypothermia]]
*[[Glanzmann thrombasthenia]]
* [[Influenza]]
*[[Graft vs. host disease]]
* Intrauterine embryo death
*[[Grey platelet syndrome]]
* [[Lactic acidosis]]
*[[Hegglin's anomaly]]
* [[Large aneurysms]]
*[[Hellp syndrome ]]
* Large operations
*[[Hemophilia ]]
* Large vascular prostheses
*[[Henoch-schonlein purpura]]
* [[Leptospirosis]]
*[[Hereditary hemorrhagic telangiectasia]]
* [[Leukemia]]
*[[Hermansky-pudlak syndrome]]
* [[Malabsorption]]
*[[Hyperglobulinemia]]
* [[Malaria]]
*[[Hyperviscosity]]
* [[Marfan's Syndrome]]
*[[Hypothermia]]
* [[Measles]]
*[[Influenza]]
* [[Metastases]]
*[[Intrauterine embryo death]]
* Miscellaneous heritable disorders of connective tissue
*[[Lactic acidosis]]
* [[Myeloproliferative syndrome]]
*[[Large aneurysms]]
* [[Myelodysplasia]]
*[[Large operations]]
* [[Myocardial Infarction]]
*[[Large vascular prostheses]]
* Nonthrombocytopenic purpura
*[[Leptospirosis]]
* [[Osler's Disease]]
*[[Leukemia]]
* [[Osteogenesis imperfecta]]
*[[Liver failure]]
* Pachymeningeosis haemorrhagica interna
*[[Malabsorption]]
* [[Paraproteinemia]]
*[[Malaria]]
* Parenteral nutrition
*[[Marfan's syndrome]]
* [[Pernicious anemia]]
*[[Measles]]
* Plasminogen activators
*[[Miscellaneous heritable disorders of connective tissue]]
* Pocks
*[[Myelodysplasia]]
* Premature placenta ablation
*[[Myeloproliferative syndrome]]
* Pseudoxanthoma elasticum
*[[Myocardial infarction]]
* Pupura fulminans
*[[Nonthrombocytopenic purpura]]
* [[Rickettsia]]
*[[Osler's disease]]
* [[Scarlet Fever]]
*[[Osteogenesis imperfecta]]
* [[Scurvy]]
*[[Pachymeningeosis haemorrhagica interna]]
* Senile-atrophic/purpura senilis
*[[Paraproteinemia]]
* [[Sepsis]]
*[[Parenteral nutrition]]
* Septic abortion
*[[Pernicious anemia]]
* Severe gastrointestinal bleeding
*[[Plasminogen activators]]
* Severe hepatopathy
*[[Platelet dysfunction ]]
* [[Ddx:Shock|Shock]]
*[[Pocks]]
* State after circulatory arrest
*[[Premature placenta ablation]]
* [[Ddx:Splenomegaly|Splenomegaly with portal hypertension]]
*[[Propylthiouracil]]
* [[Syphilis]]
*[[Pseudoxanthoma elasticum]]
* [[Telangiectasia]]
*[[Pupura fulminans]]
* Therapy with cholestyramin
*[[Ramucirumab]]
* Thrombopathic thrombopenia
*[[Rattlesnake venom]]
* [[Thrombasthenia]]
*[[Renal failure]]
* [[Toxoplasmosis]]
*[[Rickettsia]]
* [[Uremia]]
*[[Scarlet fever]]
* [[Varicella]]
*[[Scurvy]]
* [[Vasculitis]]
*[[Senile-atrophic senilis]]
* [[Vitamin K deficiency]]
*[[Sepsis]]
* [[Von Willenbrand's Disease]]
*[[Septic abortion]]
* [[Warfarin]]
*[[Severe gastrointestinal bleeding]]
* [[Wiskott-Aldrich Syndrome]]
*[[Severe hepatopathy]]
 
*[[Shock]]
 
*[[Splenomegaly with portal hypertension]]
====Contraindicated medications====
*[[Syphilis]]
{{MedCondContrAbs
*[[Telangiectasia]]
|MedCond = Hemorrhagic diathesis|Clonidine}}
*[[Therapy with cholestyramin]]
*[[Thrombasthenia]]
*[[Thrombocytopenia]]
*[[Thrombopathic thrombopenia]]
*[[Toxoplasmosis]]
*[[Uremia]]
*[[Varicella]]
*[[Vascular hemostatic disorder]]
*[[Vascular purpura]]
*[[Vasculitis]]
*[[Viper venom]]
*[[Vitamin k deficiency]]
*[[Von willenbrand's disease]]
*[[Waldenström macroglobulinaemia]]
*[[Warfarin]]
*[[Wiskott-aldrich syndrome]]
}}


== References ==
== References ==
Line 136: Line 262:


[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Signs and symptoms]]
 




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Latest revision as of 21:13, 10 January 2020

Hemorrhagic diathesis
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List of terms related to Hemorrhagic diathesis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Bleeding tendency; haemostasis abnormality; hemorrhagic diathesis; bleeding diathesis

Overview

Bleeding diathesis is an unusual susceptibility to bleeding (hemorrhage) due to a defect in the system of coagulation. Several types are distinguished, ranging from mild to lethal.

Causes

Common Causes

  • Anticoagulation therapy
  • Hepatopathies
  • Hereditary coagulopathies
  • Thrombocyte impairment
  • Vitamin K deficiency

Causes by Organ System

Cardiovascular Anaphylactic shock, Bacterial endocarditis, Cyanotic cardiac vitium, Diffuse intravascular coagulation, Large vascular prostheses, Marfan's syndrome, Myocardial infarction, Vascular hemostatic disorder, Vascular purpura, Vasculitis,
Chemical/Poisoning Bothrop venom, Rattlesnake venom, Viper venom
Dental No underlying causes
Dermatologic Henoch-schonlein purpura, Measles, Nonthrombocytopenic purpura, Osler's disease, Scurvy, Senile-atrophic senilis
Drug Side Effect Anti-aggregation with aspirin, Anticoagulation inhibitors, Cobimetinib, Epoprostenol, Factor viii inhibitors, Propylthiouracil, Ramucirumab, Therapy with cholestyramin, Warfarin
Ear Nose Throat No underlying causes
Endocrine Amyloidosis, Chronic hypercortisolism, Cushing's syndrome, Hermansky-pudlak syndrome,
Environmental No underlying causes
Gastroenterologic Acute pancreatitis, Biliary cirrhosis, Cirrhosis, Faulty intestinal flora, Liver failure, Severe gastrointestinal bleeding, Severe hepatopathy, Splenomegaly with portal hypertension
Genetic Ehlers-danlos syndrome, Osteogenesis imperfecta, Pseudoxanthoma elasticum, Wiskott-aldrich syndrome
Hematologic Ehlers-danlos syndrome, Osteogenesis imperfecta, Pseudoxanthoma elasticum, Wiskott-aldrich syndrome
Iatrogenic Fibrinolysis therapy, Fibrinolytic fission products, Graft vs. host disease, Grey platelet syndrome, Large operations, Large vascular prostheses,
Infectious Disease Bacterial endocarditis, Bacterial meningitis, Cephalosporins, Dengue hemorrhagic fever, Dengue shock syndrome, Diptheria, Influenza, Leptospirosis, Malaria, Measles, Rickettsia, Scarlet fever, Scurvy, Sepsis, Syphilis, Toxoplasmosis, Varicella
Musculoskeletal/Orthopedic Myelodysplasia, Myeloproliferative syndrome
Neurologic Bacterial meningitis, Cranio cerebral trauma, Large aneurysms, Osler's disease
Nutritional/Metabolic Avitaminosis c, Cirrhosis, Dietary deficiencies, Malabsorption, Parenteral nutrition, Vitamin k deficiency
Obstetric/Gynecologic Amniotic fluid embolism, Intrauterine embryo death, Parenteral nutrition, Premature placenta ablation, Septic abortion
Oncologic Carcinomas, Leukemia, Myelodysplasia, Myeloproliferative syndrome
Ophthalmologic
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Anaphylactic shock
Renal/Electrolyte Lactic acidosis, Renal failure, Uremia
Rheumatology/Immunology/Allergy Cystic fibrosis, Dysfibrinogenemia
Sexual Syphilis
Trauma Burns, Cranio cerebral trauma, Hypothermia, Intrauterine embryo death
Urologic Uremia
Miscellaneous No underlying causes

Causes In Alphabetical Order. [1] [2]

References

  1. ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X



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