Systemic lupus erythematosus (patient information): Difference between revisions
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'''For the WikiDoc page for this topic, click [[Systemic lupus erythematosus|here]]''' | '''For the WikiDoc page for this topic, click [[Systemic lupus erythematosus|here]]''' | ||
{{Systemic lupus erythematosus (patient information)}} | {{Systemic lupus erythematosus (patient information)}} | ||
{{CMG}}; Jinhui Wu, MD '''Associate Editor-In-Chief''': [[User:Ujjwal Rastogi|Ujjwal Rastogi, MBBS]] [mailto:urastogi@perfuse.org] | {{CMG}}; Jinhui Wu, MD '''Associate Editor-In-Chief''': {{MIR}}, [[User:Ujjwal Rastogi|Ujjwal Rastogi, MBBS]] [mailto:urastogi@perfuse.org] | ||
==Overview== | ==Overview== | ||
Lupus is an autoimmune disease characterized by acute and chronic inflammation of various tissues of the body. It may affect the skin, joints, kidneys, | [[Systemic lupus erythematosus|Lupus]] is an [[autoimmune disease]] characterized by [[Acute (medicine)|acute]] and [[chronic inflammation]] of various [[tissues]] of the body. It may affect the [[skin]], [[joints]], [[kidneys]], [[brain]], [[heart]] and [[lungs]]. The underlying cause of [[systemic lupus erythematosus]] is not clear. Clinical data show it affects nine times as many women as men. Common symptoms include [[fatigue]], low [[fever]], [[muscle pain]], [[joint pain]], [[loss of appetite]], facial [[butterfly rash]], sensitivity to sunlight, [[chest pain]], and [[swollen]] [[lymph node]]s. The patient may be diagnosed with [[Systemic lupus erythematosus CT|systemic lupus erythematosus]] when he/she has 4 or more of 11 criteria designated by the [[American College of Rheumatology]] (ACR). Treatment of [[systemic lupus erythematosus]] depends on symptoms. The aim of medications is to relieve the symptoms and decrease the [[inflammation]]. Outcomes have improved in recent years. Now the 10-year survival rate for [[systemic lupus erythematosus]] patients is greater than 85%. | ||
==What are the symptoms of Systemic lupus erythematosus?== | ==What are the symptoms of Systemic lupus erythematosus?== | ||
Symptoms of systemic lupus erythematosus vary from person to person, depending the organs affected. And the symptoms may come and go. | Symptoms of [[systemic lupus erythematosus]] vary from person to person, depending the [[organs]] affected. And the symptoms may come and go. | ||
*The most common symptoms of systemic lupus erythematosus | *The most common symptoms of [[systemic lupus erythematosus]] | ||
:*[[Fatigue]] | :*[[Fatigue]] | ||
:*Low [[fever]] | :*Low [[fever]] | ||
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:*[[Hematuria]] | :*[[Hematuria]] | ||
[http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] | [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] | ||
<gallery | <gallery perrow="3"> | ||
Image:Systemic lupus erythematosus 052.jpg|Skin: Lupus, systemic erythematosus; Discoid skin lesion in patient with SLE | Image:Systemic lupus erythematosus 052.jpg|Skin: Lupus, systemic erythematosus; Discoid skin lesion in patient with SLE | ||
Image:Systemic lupus erythematosus 053.jpg|Skin: ulcer, necrotic; lupus anticoagulant in thigh | Image:Systemic lupus erythematosus 053.jpg|Skin: ulcer, necrotic; lupus anticoagulant in thigh | ||
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Call your health care provider if you develop symptoms of systemic lupus erythematosus. | Call your health care provider if you develop symptoms of systemic lupus erythematosus. | ||
==Treatment options== | ==Treatment options== | ||
Symptoms of systemic lupus | Symptoms of [[systemic lupus erythematosus]] may come and go. The aim of treatments is to relieve your symptoms and decrease the [[inflammation]]. | ||
General management: | |||
*Avoid sun exposure: Patients with [[systemic lupus erythematosus]] should better prevent from sun exposure. When going out, they are recommended to use sunscreen with higher SPF (at least 15). Wearing protective clothing is also an important way. | |||
*Keep a good sleep quality: This may help decrease [[fatigue]] in patients with [[systemic lupus erythematosus]]. | |||
[[Medication]] | |||
*[[Nonsteroidal anti-inflammatory drug]]s ([[NSAID]]s): NSAIDs may be used to control inflammation and pain in patients with [[arthritis]] or [[pleurisy]] with systemic lupus erythematosus. Usual drugs include [[ibuprofen]], [[naproxen]] and [[indomethacin]]. Usual [[side effect]]s are [[pain]], [[bleeding]] and [[ulcer]]s in upper gastrointestinal tract. | |||
*[[Corticosteroid]]s: Corticosteroids can be used to control many symptoms such as [[pain]] and [[rash]]. Side effects of corticosteroids may include a decreased ability against [[infection]], worse healing in the wound and [[osteoporosis]]. | |||
*[[Cytotoxic drug]]s: These kind of drugs are used to treat patients without good respond to [[corticosteroid]]s and always used in active peroid of systemic lupus erythematosus. They may interfere with growth of normal and neoplastic cells by cross-linking of DNA or RNA or proteins. Usual drugs include [[cyclophosphamide]] and [[azathioprine]]. Side effects include [[marrow suppression]], liver damage, [[nausea]] and [[vomiting]]. | |||
*For patients with severe organ damage such as heart, central nervous system, kindeys and lungs, treatment team may include the rheumatologist and other specialists. | *For patients with severe organ damage such as heart, central nervous system, kindeys and lungs, treatment team may include the rheumatologist and other specialists. | ||
| Line 92: | Line 95: | ||
==Prevention== | ==Prevention== | ||
The cause of | The cause of [[autoimmune]] [[disease]] is not clear, there is no way to prevent [[systemic lupus erythematosus]]. | ||
==What to expect (Outlook/Prognosis)?== | ==What to expect (Outlook/Prognosis)?== | ||
Outcomes of patients with systemic lupus erythematosus have improved in recent years. Prognosis of systemic lupus erythematosus depends on: | Outcomes of patients with [[systemic lupus erythematosus]] have improved in recent years. Prognosis of [[systemic lupus erythematosus]] depends on: | ||
* The results of [[Antiphospholipid syndrome|anti-phospholipid antibodies]]: Positive results may increase the possibility of [[pregnancy loss]] in women with [[systemic lupus erythematosus]]. | |||
* Whether the patient is involved of vital [[organs]] damage, such as the damages in [[brain]], [[lungs]], [[heart]], and [[kidney]]. | |||
==Possible complications== | ==Possible complications== | ||
Some people with SLE have abnormal deposits in the kidney cells. This leads to a condition called lupus nephritis. Patients with this condition may eventually develop kidney failure and need dialysis or a kidney transplant. | Some people with [[SLE]] have abnormal deposits in the [[kidney]] cells. This leads to a condition called [[lupus nephritis]]. Patients with this condition may eventually develop [[kidney failure]] and need [[dialysis]] or a [[kidney transplant]]. | ||
SLE causes damage to many different parts of the body, including: | [[SLE]] causes damage to many different parts of the body, including: | ||
* Blood clots in the legs (deep vein thrombosis) or lungs (pulmonary embolism) | * Blood clots in the legs ([[deep vein thrombosis]]) or [[lungs]] ([[pulmonary embolism]]) | ||
* Destruction of red blood cells (hemolytic anemia) or anemia of chronic disease | * Destruction of red blood cells ([[hemolytic anemia]]) or [[anemia of chronic disease]] | ||
* Fluid around the heart (pericarditis), endocarditis, or inflammation of the heart (myocarditis) | * Fluid around the [[heart]] ([[pericarditis]]), [[endocarditis]], or inflammation of the heart ([[myocarditis]]) | ||
* Fluid around the lungs (pleural effusions) and damage to lung tissue | * Fluid around the lungs ([[pleural effusions]]) and damage to lung tissue | ||
* Pregnancy complications, including miscarriage | * Pregnancy complications, including [[miscarriage]] | ||
* Stroke | * [[Stroke]] | ||
* Severely low blood platelets (thrombocytopenia) | * Severely low blood platelets ([[thrombocytopenia]]) | ||
* Inflammation of the blood vessels | * Inflammation of the blood vessels | ||
Latest revision as of 12:56, 17 October 2019
For the WikiDoc page for this topic, click here
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Systemic lupus erythematosus |
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Where to find medical care for Systemic lupus erythematosus? |
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Systemic lupus erythematosus On the Web |
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Directions to Hospitals Treating Systemic lupus erythematosus |
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Risk calculators and risk factors for Systemic lupus erythematosus |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Jinhui Wu, MD Associate Editor-In-Chief: Mahshid Mir, M.D. [2], Ujjwal Rastogi, MBBS [3]
Overview
Lupus is an autoimmune disease characterized by acute and chronic inflammation of various tissues of the body. It may affect the skin, joints, kidneys, brain, heart and lungs. The underlying cause of systemic lupus erythematosus is not clear. Clinical data show it affects nine times as many women as men. Common symptoms include fatigue, low fever, muscle pain, joint pain, loss of appetite, facial butterfly rash, sensitivity to sunlight, chest pain, and swollen lymph nodes. The patient may be diagnosed with systemic lupus erythematosus when he/she has 4 or more of 11 criteria designated by the American College of Rheumatology (ACR). Treatment of systemic lupus erythematosus depends on symptoms. The aim of medications is to relieve the symptoms and decrease the inflammation. Outcomes have improved in recent years. Now the 10-year survival rate for systemic lupus erythematosus patients is greater than 85%.
What are the symptoms of Systemic lupus erythematosus?
Symptoms of systemic lupus erythematosus vary from person to person, depending the organs affected. And the symptoms may come and go.
- The most common symptoms of systemic lupus erythematosus
- Fatigue
- Low fever
- Muscle pain
- Joint pain
- Loss of appetite
- Facial butterfly rash
- Sensitivity to sunlight
- Chest pain
- Swollen lymph nodes
- Abnormal blood clotting
- Other symptoms depends on the orgnas affected.
- Headache, new paralysis, or seizures
- Personality change, even psychosis
- Arrhythmias
- Abdominal pain, nausea or vomiting
- Hematuria
-
Skin: Lupus, systemic erythematosus; Discoid skin lesion in patient with SLE
-
Skin: ulcer, necrotic; lupus anticoagulant in thigh
-
Skin: lupus, erythematosus, subacute; Papulosquamous diseases
-
Skin: lupus, erythematosus; Papulosquamous diseases
-
Skin: lupus, erythematosus; papulosquamous diseases
-
Skin: alopecia, secondary lupus erythematosus; hair loss
-
Skin: discoid lupus, face
Diseases that can have similar symptoms are
What causes Systemic lupus erythematosus?
Systemic lupus erythematosus (SLE) is an autoimmune disease, which means the body's immune system mistakenly attacks healthy tissue. This leads to long-term (chronic) inflammation.
The underlying cause of autoimmune diseases is not fully known. SLE is much more common in women than men. It may occur at any age, but appears most often in people between the ages of 10 and 50. African Americans and Asians are affected more often than people from other races.
SLE may also be caused by certain drugs. For information on this cause, see Drug-induced lupus erythematosus
Who is at highest risk?
The underlying cause of this autoimmune disease is not clear. Clinical data show the onset of systemic lupus erythematosus is associated with the following factors:
- Female: SLE affects nine times as many women as men.
- Age: From 10 to 50
- Race: African Americans and Asians are affected more often than people from other races.
- Drugs, such as chlorpromazine, hydralazine, isoniazid, methyldopa, penicillamine, procainamide, quinidine and sulfasalazine.
Diagnosis
The American College of Rheumatology has designated 11 criteria for classification. If the patient has four or more criteria, he/she can be diagnosed systemic lupus erythematosus.
- Malar rash: This butterfly rash below the eyes may be flat or elevated.
- Discoid rash: These are red, raised patches with scaling of the overlying skin. A subgroup of patients have "discoid lupus" with only skin involvement and do not have systemic lupus erythematosus. All patients with discoid lupus should be screened for systemic involvement.
- Sensitivity to sunligh: A rash develops in response to sun exposure.
- Oral ulcers: The doctor can observe painless sores in the nose or mouth.
- Arthritis: The arthritis of lupus usually demonstrate swelling and tenderness of the joints.
- Serositis: This means an inflammation of various "sacs" or membranes, such as pericarditis, pleurisy or peritonitis. Patients with these inflammations may demonstrate symptoms such as pain, shortness of breath, or forced posture.
- Kidney disease: Patients with lupus may demonstrate persistent loss of protein, or inflammation during analysis of the urine.
- Neurological disorder: Patients with lupus may show paralysis, or seizures, personality change, even psychosis.
- Blood disorder: Patients with lupus may show low blood counts of various blood components.
- Immunologic disorder: Some antibodies tests may be positive in patients with lupus. It includes antibody tests such as anti-double strand (ds) DNA, anti-phospholipid antibodies and anti-smith antibodies.
- Positive antinuclear antibody: It is a very valuable test to rule out lupus. More than 98% of patients with lupus have a positive ANA test result.
When to seek urgent medical care?
Call your health care provider if you develop symptoms of systemic lupus erythematosus.
Treatment options
Symptoms of systemic lupus erythematosus may come and go. The aim of treatments is to relieve your symptoms and decrease the inflammation.
General management:
- Avoid sun exposure: Patients with systemic lupus erythematosus should better prevent from sun exposure. When going out, they are recommended to use sunscreen with higher SPF (at least 15). Wearing protective clothing is also an important way.
- Keep a good sleep quality: This may help decrease fatigue in patients with systemic lupus erythematosus.
- Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs may be used to control inflammation and pain in patients with arthritis or pleurisy with systemic lupus erythematosus. Usual drugs include ibuprofen, naproxen and indomethacin. Usual side effects are pain, bleeding and ulcers in upper gastrointestinal tract.
- Corticosteroids: Corticosteroids can be used to control many symptoms such as pain and rash. Side effects of corticosteroids may include a decreased ability against infection, worse healing in the wound and osteoporosis.
- Cytotoxic drugs: These kind of drugs are used to treat patients without good respond to corticosteroids and always used in active peroid of systemic lupus erythematosus. They may interfere with growth of normal and neoplastic cells by cross-linking of DNA or RNA or proteins. Usual drugs include cyclophosphamide and azathioprine. Side effects include marrow suppression, liver damage, nausea and vomiting.
- For patients with severe organ damage such as heart, central nervous system, kindeys and lungs, treatment team may include the rheumatologist and other specialists.
Medications to avoid
Patients diagnosed with systemic lupus erythematosus should avoid using the following medications:
- Procainamide
If you have been diagnosed with systemic lupus erythematosus, consult your physician before starting or stopping any of these medications.
Where to find medical care for Systemic lupus erythematosus?
Directions to Hospitals Treating systemic lupus erythematosus
Prevention
The cause of autoimmune disease is not clear, there is no way to prevent systemic lupus erythematosus.
What to expect (Outlook/Prognosis)?
Outcomes of patients with systemic lupus erythematosus have improved in recent years. Prognosis of systemic lupus erythematosus depends on:
- The results of anti-phospholipid antibodies: Positive results may increase the possibility of pregnancy loss in women with systemic lupus erythematosus.
- Whether the patient is involved of vital organs damage, such as the damages in brain, lungs, heart, and kidney.
Possible complications
Some people with SLE have abnormal deposits in the kidney cells. This leads to a condition called lupus nephritis. Patients with this condition may eventually develop kidney failure and need dialysis or a kidney transplant.
SLE causes damage to many different parts of the body, including:
- Blood clots in the legs (deep vein thrombosis) or lungs (pulmonary embolism)
- Destruction of red blood cells (hemolytic anemia) or anemia of chronic disease
- Fluid around the heart (pericarditis), endocarditis, or inflammation of the heart (myocarditis)
- Fluid around the lungs (pleural effusions) and damage to lung tissue
- Pregnancy complications, including miscarriage
- Stroke
- Severely low blood platelets (thrombocytopenia)
- Inflammation of the blood vessels
Sources
http://www.nlm.nih.gov/medlineplus/ency/article/000435.htm Template:WH Template:WS