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| {{DrugProjectFormSinglePage
| | #REDIRECT [[Estradiol]] |
| |authorTag={{DB}}
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| |genericName=Estradiol
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| |aOrAn=an
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| |drugClass=estrogen
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| |indicationType=treatment
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| |indication=moderate to severe vasomotor symptoms, symptoms of vulvar and vaginal atrophy due to menopause, hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, postmenopausal osteoporosis and prevention of postmenopausal osteoporosis
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| |hasBlackBoxWarning=Yes
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| |adverseReactions=breast pain, upper respiratory tract infections, headaches, abdominal pain, pain, and edema
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| |blackBoxWarningTitle=<span style="color:#FF0000;">WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER AND PROBABLE DEMENTIA</span>
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| |blackBoxWarningBody=Estrogen-Alone Therapy:
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| *There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens
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| *Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia
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| *The Women’s Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT)
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| *The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older
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| *There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens
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| *Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia
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| *The Women’s Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT)
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| *The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older
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| Estrogen Plus Progestin Therapy:
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| *Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia
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| *The WHI estrogen plus progestin substudy reported increased risks of stroke, DVT, pulmonary embolism (PE), and myocardial infarction (MI)
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| *The WHI estrogen plus progestin substudy reported increased risks of invasive breast cancer
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| The WHIMS estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older
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| |offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Estradiol patch in adult patients.
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| |offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Estradiol patch in adult patients.
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| |offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Estradiol patch in pediatric patients.
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| |offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Estradiol patch in pediatric patients.
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| |alcohol=Alcohol-Estradiol patch interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
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| }}
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