Magnesium hydroxide: Difference between revisions

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|authorTag={{Ammu}}
|authorTag={{Ammu}}
|genericName=Magnesium hydroxide
|genericName=Magnesium hydroxide
|aOrAn=a
|aOrAn=an
|drugClass=antacid
|drugClass=[[antacid]]
|indicationType=treatment
|indicationType=treatment
|indication=saline Laxative and antacid
|indication=saline [[laxative]] and [[antacid]]
|adverseReactions=[[nausea]], [[vomiting]] , [[abdominal pain]]
|adverseReactions=[[hypermagnesemia]]
|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>
Line 24: Line 24:
* Do not take more than 12 teaspoons in 24 hours
* Do not take more than 12 teaspoons in 24 hours
* Do not use maximum dosage for more than 2 weeks
* Do not use maximum dosage for more than 2 weeks
|offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
|offLabelAdultGuideSupport=* Indigestion <ref name=NIH>{{cite web | title = Magnesium NIH | url =http://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/ }}</ref>
 
|offLabelAdultNoGuideSupport=* Calcium renal calculus; Prophylaxis <ref>{{cite book | last = Wuthrich | first = Rudolf | title = Urolithiasis : therapy prevention | publisher = Springer | location = S.l | year = 2012 | isbn = 978-3-642-70714-8 }}</ref>
<!--Non–Guideline-Supported Use (Adult)-->
* [[Constipation]].
|offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
 
<!--Pediatric Indications and Dosage-->


<!--FDA-Labeled Indications and Dosage (Pediatric)-->
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
|fdaLIADPed======Laxative=====
|fdaLIADPed======Laxative=====
* Children 6 to under 12 years: 1 to 2 tablespoons
* Children 6 to under 12 years: 1 to 2 tablespoons.
* Children 2 to under 6 years: 1 to 3 teaspoons
* Children 2 to under 6 years: 1 to 3 teaspoons.
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
|offLabelPedGuideSupport=* Indigestion <ref name=NIH>{{cite web | title = Magnesium NIH | url =http://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/ }}</ref>
 
* [[Constipation]].
<!--Non–Guideline-Supported Use (Pediatric)-->
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Magnesium hydroxide in pediatric patients.
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Contraindications-->
|warnings=Use caution if the following conditions coexist.
|warnings=Use caution if the following conditions coexist.
* Kidney disease  
* Kidney disease.
* A magnesium-restricted diet  
* A magnesium-restricted diet.
* Stomach pain, nausea or vomiting  
* Stomach pain, [[nausea]] or [[vomiting]].
* A sudden change in bowel habits that lasts over 2 weeks
* A sudden change in bowel habits that lasts over 2 weeks.
* Ask a doctor or pharmacist before use if you are taking any other drug.
* Ask a doctor or pharmacist before use if you are taking any other drug.
* Antacids may interact with certain prescription drugs ° laxatives may affect how other drugs work, so should be taken 2 or more hours before or after other drugs.
* Antacids may interact with certain prescription drugs ° laxatives may affect how other drugs work, so should be taken 2 or more hours before or after other drugs.
* When using this product as an antacid, it may have a laxative effect.
* When using this product as an antacid, it may have a laxative effect.
 
* Stop use and ask a doctor if have following symptoms.
Stop use and ask a doctor if ° you have rectal bleeding or no bowel movement after using this product. These could be signs of a serious condition ° You need to use a laxative for more than 1 week ° symptoms last more than 2 weeks.
:* Rectal bleeding or no bowel movement after using this product. These could be signs of a serious condition  
 
:* If pregnant or breast-feeding, ask a health professional before use.
If pregnant or breast-feeding, ask a health professional before use.
|postmarketing======Endocrine metabolic=====
|drugInteractions=* Drug
[[Hypermagnesemia]]
:* Description
|FDAPregCat=D
 
<!--Use in Specific Populations-->
|useInPregnancyFDA=* '''Pregnancy Category'''
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''


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<!--Administration and Monitoring-->
<!--Administration and Monitoring-->
|administration=* Oral
|administration=* [[Oral]]
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.


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<!--Overdosage-->
<!--Overdosage-->
|overdose====Acute Overdose===
|drugBox={{Chembox2
 
| Verifiedfields = changed
====Signs and Symptoms====
| Watchedfields = changed
 
| verifiedrevid = 476992492
* Description
| ImageFile = Hydroxid hořečnatý.PNG
 
| ImageSize =
====Management====
| ImageName = Magnesium hydroxide
 
| ImageFile1 = Brucitestructure.png
* Description
| ImageSize1 =
 
| ImageName1 = Magnesium hydroxide
===Chronic Overdose===
| IUPACName = Magnesium hydroxide
 
| OtherNames = Milk of magnesia
There is limited information regarding <i>Chronic Overdose</i> of {{PAGENAME}} in the drug label.
|Section1={{Chembox Identifiers
 
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
<!--Pharmacology-->
| ChemSpiderID = 14107
 
| ChEMBL_Ref = {{ebicite|changed|EBI}}
<!--Drug box 2-->
| ChEMBL = 1200718
|drugBox=<!--Mechanism of Action-->
| UNII_Ref = {{fdacite|correct|FDA}}
|mechAction=*
| UNII = NBZ3QY004S
 
| InChI = 1/Mg.2H2O/h;2*1H2/q+2;;/p-2
<!--Structure-->
| InChIKey = VTHJTEIRLNZDEV-NUQVWONBAW
|structure=*
| ChEBI_Ref = {{ebicite|correct|EBI}}
 
| ChEBI = 6637
: [[File:{{PAGENAME}}01.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
| SMILES = [Mg+2].[OH-].[OH-]
 
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
<!--Pharmacodynamics-->
| StdInChI = 1S/Mg.2H2O/h;2*1H2/q+2;;/p-2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = VTHJTEIRLNZDEV-UHFFFAOYSA-L
| CASNo = 1309-42-8
| CASNo_Ref = {{cascite|correct|CAS}}
| PubChem = 14791
| RTECS = OM3570000
| ATCCode_prefix = A02
| ATCCode_suffix = AA04
| ATC_Supplemental = {{ATC|G04|BX01}}
| EINECS = 215-170-3
}}
|Section2={{Chembox Properties
| Formula = Mg(OH)<sub>2</sub>
| MolarMass = 58.3197 g/mol
| Appearance = White solid
| Odor = odorless
| Density = 2.3446 g/cm<sup>3</sup>
| MeltingPtC = 350
| Melting_notes = decomposes
| Solubility = 0.00064 g/100 mL (25 °C) <br> 0.004 g/100 mL (100 °C)
| SolubilityProduct = 1.5×10<sup>−11</sup>
| RefractIndex = 1.559<ref>Pradyot Patnaik. ''Handbook of Inorganic Chemicals''. McGraw-Hill, 2002, ISBN 0-07-049439-8</ref>}}
|Section3={{Chembox Structure
| CrystalStruct = Hexagonal, [[Pearson symbol|hP3]]<ref>{{cite journal|doi=10.1143/JPSJ.39.317|title=Magnetic Behaviours of a Random Magnet, NipMg(1-p)(OH2)|author=Toshiaki Enoki and Ikuji Tsujikawa |journal=J. Phys. Soc. Jpn. |volume=39|year=1975|pages=317–323|issue=2}}</ref>
| SpaceGroup = P{{overline|3}}m1 No. 164
| pKb = 2.6
| Coordination =
| LattConst_a = 0.312 nm
| LattConst_b =
| LattConst_c = 0.473 nm
| LattConst_alpha =
| LattConst_beta =
| LattConst_gamma =
| MolShape =
| OrbitalHybridisation =
| Dipole =
}}
|Section5={{Chembox Thermochemistry
| DeltaHf = −924.7&nbsp;kJ·mol<sup>−1</sup><ref name=b1>{{cite book| author = Zumdahl, Steven S.|title =Chemical Principles 6th Ed.| publisher = Houghton Mifflin Company| year = 2009| isbn = 0-618-94690-X|page=A22}}</ref>
| DeltaGf = -833.7 kJ/mol
| Entropy = 64&nbsp;J·mol<sup>−1</sup>·K<sup>−1</sup><ref name=b1/>
| HeatCapacity = 77.03 J/mol K
}}
|Section7={{Chembox Hazards
| ExternalMSDS = [https://fscimage.fishersci.com/msds/13405.htm External MSDS]
| EUIndex = Not listed
| MainHazards =
| NFPA-H = 1
| NFPA-F = 0
| NFPA-R = 0
| NFPA-O =
| FlashPt = Non-flammable
| AutoignitionPt =
| LD50 = 8500 mg/kg (rat, oral)
}}
|Section8={{Chembox Related
| OtherAnions = [[Magnesium oxide]]
| OtherCations = [[Beryllium hydroxide]]<br/>[[Calcium hydroxide]]<br/>[[Strontium hydroxide]]<br/>[[Barium hydroxide]]
}}
}}
|structure=<!--Pharmacodynamics-->
|PD=There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.
|PD=There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.


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* Drink a full glass (8 ounces) of liquid with each dose
* Drink a full glass (8 ounces) of liquid with each dose
* May be taken as a single or divided dose
* May be taken as a single or divided dose
=====Antacid=====
* Do not take more than 12 teaspoons in 24 hours
* Do not use maximum dosage for more than 2 weeks
=====Laxative=====
* Adults and children 12 years and older: 2 to 4 tablespoons
* Adults and children 12 years and older: 2 to 4 tablespoons
* Children 6 to under 12 years: 1 to 2 tablespoons
* Children 6 to under 12 years: 1 to 2 tablespoons
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* Children under 2 years: ask a doctor
* Children under 2 years: ask a doctor
=====Antacid=====
=====Antacid=====
* Do not take more than 12 teaspoons in 24 hours
* Do not use maximum dosage for more than 2 weeks
* Adults and children 12 years and older: 1 to 3 teaspoons with water, up to 4 times daily
* Adults and children 12 years and older: 1 to 3 teaspoons with water, up to 4 times daily
* Children under 12 years: ask a doctor
* Children under 12 years: ask a doctor
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<!--Look-Alike Drug Names-->
<!--Look-Alike Drug Names-->
|lookAlike=* A® — B®<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher =  | date =  }}</ref>
<!--Drug Shortage Status-->
|drugShortage=
|drugShortage=
}}
{{LabelImage
|fileName=Magnessium hydroxide.jpg
}}
{{LabelImage
|fileName=DailyMed - MAGNESIUM HYDROXIDE- magnesium hydroxide liquid  .png
}}
}}
<!--Pill Image-->
<!--Pill Image-->
Line 162: Line 215:


[[Category:Drug]]
[[Category:Drug]]
[[Category:Laxatives]]
[[Category:Food acidity regulators]]
[[Category:Bases]]
[[Category:Hydroxides]]
[[Category:Magnesium compounds]]

Latest revision as of 16:38, 20 August 2015

Magnesium hydroxide
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Overview

Magnesium hydroxide is an antacid that is FDA approved for the treatment of saline laxative and antacid. Common adverse reactions include hypermagnesemia.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Laxative
  • Relieves occasional constipation; generally produces a bowel movement in 1/2 to 6 hours.
  • Drink a full glass (8 ounces) of liquid with each dose
  • Adults and children 12 years and older: 2 to 4 tablespoons
  • Adults and children 12 years and older: 1 to 3 teaspoons with water, up to 4 times daily
Antacid
  • Relieves heartburn, sour stomach & acid indigestion.
  • Do not take more than 12 teaspoons in 24 hours
  • Do not use maximum dosage for more than 2 weeks

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

  • Indigestion [1]

Non–Guideline-Supported Use

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Laxative
  • Children 6 to under 12 years: 1 to 2 tablespoons.
  • Children 2 to under 6 years: 1 to 3 teaspoons.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Magnesium hydroxide in pediatric patients.

Contraindications

There is limited information regarding Magnesium hydroxide Contraindications in the drug label.

Warnings

Use caution if the following conditions coexist.

  • Kidney disease.
  • A magnesium-restricted diet.
  • Stomach pain, nausea or vomiting.
  • A sudden change in bowel habits that lasts over 2 weeks.
  • Ask a doctor or pharmacist before use if you are taking any other drug.
  • Antacids may interact with certain prescription drugs ° laxatives may affect how other drugs work, so should be taken 2 or more hours before or after other drugs.
  • When using this product as an antacid, it may have a laxative effect.
  • Stop use and ask a doctor if have following symptoms.
  • Rectal bleeding or no bowel movement after using this product. These could be signs of a serious condition
  • If pregnant or breast-feeding, ask a health professional before use.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Magnesium hydroxide Clinical Trials Experience in the drug label.

Postmarketing Experience

Endocrine metabolic

Hypermagnesemia

Drug Interactions

There is limited information regarding Magnesium hydroxide Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): D There is no FDA guidance on usage of Magnesium hydroxide in women who are pregnant.
Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Magnesium hydroxide in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Magnesium hydroxide during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Magnesium hydroxide with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Magnesium hydroxide with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Magnesium hydroxide with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Magnesium hydroxide with respect to specific gender populations.

Race

There is no FDA guidance on the use of Magnesium hydroxide with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Magnesium hydroxide in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Magnesium hydroxide in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Magnesium hydroxide in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Magnesium hydroxide in patients who are immunocompromised.

Administration and Monitoring

Administration

Monitoring

There is limited information regarding Monitoring of Magnesium hydroxide in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Magnesium hydroxide in the drug label.

Overdosage

There is limited information regarding Magnesium hydroxide overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

Template:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox entryTemplate:Chembox ECNumberTemplate:Chembox E numberTemplate:Chembox RTECSTemplate:Chembox AppearanceTemplate:Chembox OdourTemplate:Chembox DensityTemplate:Chembox MeltingPtTemplate:Chembox SolubilityInWaterTemplate:Chembox SolubilityProductTemplate:Chembox RefractIndexTemplate:Chembox StructureTemplate:Chembox ThermochemistryTemplate:Chembox NFPATemplate:Chembox FlashPtTemplate:Chembox Lethal amounts (set)Template:Chembox OtherAnionsTemplate:Chembox OtherCationsTemplate:Chembox Supplement
Template:Chembox header2 | Magnesium hydroxide
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
UNII
Properties
Mg(OH)2
Molar mass 58.3197 g/mol
Hazards
Related compounds
Template:Chembox header2 | Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Mechanism of Action

There is limited information regarding Magnesium hydroxide Mechanism of Action in the drug label.

Structure

There is limited information regarding Magnesium hydroxide Structure in the drug label.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Magnesium hydroxide in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Magnesium hydroxide in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Magnesium hydroxide in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Magnesium hydroxide in the drug label.

How Supplied

  • Each 5 mL teaspoon contains: magnesium 165mg and sodium 2 mg

Storage

  • Store at room temperature
  • Protect from freezing

Images

Drug Images

{{#ask: Page Name::Magnesium hydroxide |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Magnesium hydroxide |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

Laxative
  • Shake well before using
  • Drink a full glass (8 ounces) of liquid with each dose
  • May be taken as a single or divided dose
  • Adults and children 12 years and older: 2 to 4 tablespoons
  • Children 6 to under 12 years: 1 to 2 tablespoons
  • Children 2 to under 6 years: 1 to 3 teaspoons
  • Children under 2 years: ask a doctor
Antacid
  • Do not take more than 12 teaspoons in 24 hours
  • Do not use maximum dosage for more than 2 weeks
  • Adults and children 12 years and older: 1 to 3 teaspoons with water, up to 4 times daily
  • Children under 12 years: ask a doctor

Precautions with Alcohol

  • Alcohol-Magnesium hydroxide interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

  • MAGNESIUM HYDROXIDE ®[4]

Look-Alike Drug Names

There is limited information regarding Magnesium hydroxide Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ 1.0 1.1 "Magnesium NIH".
  2. ↑ Wuthrich, Rudolf (2012). Urolithiasis : therapy prevention. S.l: Springer. ISBN 978-3-642-70714-8.
  3. ↑ Pradyot Patnaik. Handbook of Inorganic Chemicals. McGraw-Hill, 2002, ISBN 0-07-049439-8
  4. ↑ "MAGNESIUM HYDROXIDE- magnesium hydroxide liquid".

{{#subobject: 

 |Label Page=Magnesium hydroxide
 |Label Name=Magnessium hydroxide.jpg

}}

{{#subobject: 

 |Label Page=Magnesium hydroxide
 |Label Name=DailyMed - MAGNESIUM HYDROXIDE- magnesium hydroxide liquid  .png

}}

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