Bone marrow suppression: Difference between revisions

	WikiDoc Resources for Bone marrow suppression
Articles
Most recent articles on Bone marrow suppression Most cited articles on Bone marrow suppression Review articles on Bone marrow suppression Articles on Bone marrow suppression in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Bone marrow suppression Images of Bone marrow suppression Photos of Bone marrow suppression Podcasts & MP3s on Bone marrow suppression Videos on Bone marrow suppression
Evidence Based Medicine
Cochrane Collaboration on Bone marrow suppression Bandolier on Bone marrow suppression TRIP on Bone marrow suppression
Clinical Trials
Ongoing Trials on Bone marrow suppression at Clinical Trials.gov Trial results on Bone marrow suppression Clinical Trials on Bone marrow suppression at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Bone marrow suppression NICE Guidance on Bone marrow suppression NHS PRODIGY Guidance FDA on Bone marrow suppression CDC on Bone marrow suppression
Books
Books on Bone marrow suppression
News
Bone marrow suppression in the news Be alerted to news on Bone marrow suppression News trends on Bone marrow suppression
Commentary
Blogs on Bone marrow suppression
Definitions
Definitions of Bone marrow suppression
Patient Resources / Community
Patient resources on Bone marrow suppression Discussion groups on Bone marrow suppression Patient Handouts on Bone marrow suppression Directions to Hospitals Treating Bone marrow suppression Risk calculators and risk factors for Bone marrow suppression
Healthcare Provider Resources
Symptoms of Bone marrow suppression Causes & Risk Factors for Bone marrow suppression Diagnostic studies for Bone marrow suppression Treatment of Bone marrow suppression
Continuing Medical Education (CME)
CME Programs on Bone marrow suppression
International
Bone marrow suppression en Espanol Bone marrow suppression en Francais
Business
Bone marrow suppression in the Marketplace Patents on Bone marrow suppression
Experimental / Informatics
List of terms related to Bone marrow suppression

VisualWikitext

Latest revision as of 14:51, 17 August 2015

For congenital bone marrow suppression click here.
For acquired bone marrow suppression click here.
For the main page of bone marrow disorders click here.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Rim Halaby, M.D. [2]; Serge Korjian M.D.

Synonyms and keywords: Bone marrow failure, bone marrow depression, myelosuppression, myelosuppressive disorder

Overview

Bone marrow suppression is the reduction in numbers of cells in the bone marrow, that can be either congenital or acquired. Acquired bone marrow suppression may be any of the following: 1) myelosuppression characterized by a reduction in the number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes), or 2) immunosuppression characterized by a reduction in the number of lymphoid lineage cells (T-cell, B-cell, NK cell). Bone marrow suppression can be a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine. NSAIDs may also cause bone marrow suppression. The risk is especially high in chemotherapy for leukemia.

Classification

Shown below is an algorthim that depicts the classification of bone marrow suppression. For congenital bone marrow suppression click here. For acquired bone marrow suppression click here.

Myelodysplasia

All hematopoietic lineages

Aplastic anemia (aplastic pancytopenia)

Paroxysmal nocturnal hemoglobinuria (PNH)

Myelosuppression

Pure red cell aplasia (erythroblastopenia)

One lineage

Neutropenia (granulocytopenia and agranulocytosis)

Acquired bone marrow suppression

Amegakaryocytic thrombocytopenia

T-cell immunosuppression

Immunosuppression

B-cell immunosuppression

Bone Marrow Suppression

NK cell immunosuppression

Multiple lineages

Congenital bone marrow suppression

One lineage

Causes

Drug Side Effects

Natural History, Complications and Prognosis

The bone marrow is where blood cells are formed, and this process is slowed or stopped when bone marrow suppression is caused. This can rapidly lead to life-threatening infection as the body cannot produce leukocytes in response to invading bacteria and viruses, as well as anemia due to a lack of red blood cells and spontaneous severe bleeding due to deficiency of platelets.

Treatment

Bone marrow suppression due to azathioprine can be treated by changing to another medication such as mycophenolate mofetil (for organ transplants) or other disease-modifying drugs in rheumatoid arthritis or Crohn's disease. Bone marrow suppression due to anti-cancer chemotherapy is much harder to treat and often involves hospital admission, strict infection control, and aggressive use of intravenous antibiotics at the first sign of infection.

References

Template:WikiDoc Sources

@@ Line 1: / Line 1: @@
+__NOTOC__
+'''''For congenital bone marrow suppression click [[congenital bone marrow disorders#Inherited Bone Marrow Failure Syndromes|here]].'''''<br>
+'''''For acquired bone marrow suppression click [[acquired bone marrow disorders#Bone Marrow Suppression|here]].'''''<br>
+'''''For the main page of bone marrow disorders click [[bone marrow disorders|here]].'''''
 {{SI}}
-{{CMG}}
+{{CMG}}; {{AE}} {{YD}}; {{Rim}}; {{SSK}}
+{{SK}} Bone marrow failure, bone marrow depression, myelosuppression, myelosuppressive disorder
 ==Overview==
-'''Bone marrow suppression''' is a serious side effect of [[chemotherapy]] and certain drugs affecting the immune system such as [[azathioprine]]. NSAIDS may also cause bone marrow suppression. The risk is especially high in chemotherapy for [[leukemia|leukaemia]].
+Bone marrow suppression is the reduction in numbers of cells in the [[bone marrow]], that can be either congenital or acquired.  Acquired bone marrow suppression may be any of the following: 1) myelosuppression characterized by a reduction in the number of [[myeloid]] lineage cells ([[RBC]], [[neutrophils]], [[basophils]], [[eosinophils]], [[monocyte]]s, [[platelets]], [[mastocytes]]), or 2) immunosuppression characterized by a reduction in the number of [[lymphoid]] lineage cells ([[T-cell]], [[B-cell]], [[NK cell]]). Bone marrow suppression can be a serious side effect of [[chemotherapy]] and certain drugs affecting the immune system such as [[azathioprine]]. [[NSAID]]s may also cause bone marrow suppression. The risk is especially high in chemotherapy for [[leukemia]].
-The [[bone marrow]] is where blood cells are formed, and this process is slowed or stopped when bone marrow suppression is caused. This can rapidly lead to life-threatening [[infection]] as the body cannot produce [[leukocytes]] in response to invading [[bacterium|bacteria]] and [[viruses]], as well as anaemia due to a lack of [[red blood cells]] and spontaneous severe bleeding due to deficiency of [[platelets]].
+==Classification==
+Shown below is an algorthim that depicts the classification of bone marrow suppression.  For congenital bone marrow suppression click [[congenital bone marrow disorders#Inherited Bone Marrow Failure Syndromes|here]].  For acquired bone marrow suppression click [[acquired bone marrow disorders#Bone Marrow Suppression|here]].
-Bone marrow suppression due to azathioprine can be treated by changing to another medication such as [[mycophenolate mofetil]] (for organ transplants) or other disease-modifying drugs in [[rheumatoid arthritis]] or [[Crohn's disease]]. Bone marrow suppression due to anti-cancer chemotherapy is much harder to treat and often involves hospital admission, strict infection control, and aggressive use of intravenous [[antibiotics]] at the first sign of infection.
+{{Family tree/start}}
+{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | | | | | | | | | | | |,| D01 | | | | | | | | D01= [[Myelodysplasia]]}}
-===Causes===
+{{Family tree | | | | | | | | | | | | | |!| | | | | | | | | | }}
+{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | | | | | | | |,| C01 |+| D02 | | | | | | | | C01= All hematopoietic lineages| D02= [[Aplastic anemia]] ([[aplastic pancytopenia]])}}
+{{Family tree | | | | | | | | | |!| | | |!| | | | | | | | | | }}
-===Drug Side Effect===
+{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | | | | | | | |!| | | |`| D03 | | | | | | | | D03= [[Paroxysmal nocturnal hemoglobinuria]] ([[PNH]])}}
+{{Family tree |boxstyle= padding: 0; background: #66CDAA; | | | | | |,| B01 |(| | | | | | | | | | | | | | | B01= Myelosuppression}}
+{{Family tree |boxstyle= padding: 0; background: #A9A9A9; | | | | | |!| | | |!| | | |,| D04 | | | | | | | | D04= [[Pure red cell aplasia]] ([[erythroblastopenia]])}}
+{{Family tree | | | | | |!| | | |!| | | |!| | | | | | | | | | }}
+{{Family tree |boxstyle= padding: 0; background: #A9A9A9; | | | | | |!| | | |`| C02 |+| D05 | | | | | | | | C02= One lineage|D05= [[Neutropenia]] ([[granulocytopenia]] and [[agranulocytosis]])}}
+{{Family tree |boxstyle= padding: 0; background: #FFA07A; | | | |,| A01 | | | | | | |!| | | | | | | | | | A01= '''[[Acquired bone marrow suppression]]''' }}
+{{Family tree |boxstyle= padding: 0; background: #A9A9A9; | | | |!| |!| | | | | | | |`| D06 | | | | | | | | D06= [[Amegakaryocytic thrombocytopenia]]}}
+{{Family tree |boxstyle= padding: 0; background: #FAEBD7; | | | |!| |!| | | |,| C22 | | | | | | | | | | | | C22= [[T-cell immunosuppression]]}}
+{{Family tree |boxstyle= padding: 0; background: #66CDAA; | | | |!| |`| B11 |(| | | | | | | | | | | | | | | B11= [[Immunosuppression]]}}
+{{Family tree |boxstyle= padding: 0; background: #FAEBD7; | | | |!| | | | | |)| C23 | | | | | | | | | | | | C23= [[B-cell immunosuppression]]}}
+{{Family tree |boxstyle= padding: 0; background: #FFA07A; | | A00 | | | | | |!| | | | | | | | | | | | | | | A00= '''Bone Marrow Suppression'''}}
+{{Family tree |boxstyle= padding: 0; background: #FAEBD7; | | | |!| | | | | |`| C24 | | | | | | | | | | | | C24= [[ NK cell immunosuppression]]}}
+{{Family tree | | | |!| | | | | | | | | | | | | | | | | | | | | }}
+{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | |!| |,|-|-|-|-| B01 | | | | | | | | | | | | | | | | B01= Multiple lineages }}
+{{Family tree |boxstyle= padding: 0; background: #A9A9A9; | | | |!| |!| | | }}
+{{Family tree |boxstyle= padding: 0; background: #FFA07A; | | | |`| A01 | | | | | | | | | | | A01= '''[[Congenital bone marrow suppression]]''' }}
+{{Family tree |boxstyle= padding: 0; background: #A9A9A9; | | | | | |!| | | }}
+{{Family tree |boxstyle= padding: 0; background: #A9A9A9; | | | | | |`|-|-|-|-| B11 | | | | | | | | | | | | | | | | B11= One lineage}}
+{{Family tree/end}}
+==Causes==
+===Drug Side Effects===
 * [[Albendazole]]
+* [[Altretamine]]
+* [[Bosutinib]]
+* [[Cladribine]]
 * [[Cyclophosphamide]]
-*[[Sulfasalazine]]
+* [[Dactinomycin]]
+* [[Daunorubicin liposome]]
+* [[Dexrazoxane]]
+* [[Diethylpropion]]
+* [[Ethosuximide]]
+* [[Fludarabine]]
+* [[Guanidine]]
+* [[Hydroxyurea (patient information)]]
+* [[Idarubicin hydrochloride]]
+* [[Imipenem-Cilastatin]]
+* [[Ixabepilone]]
+* [[Mercaptopurine]]
+* [[Mitomycin]]
+* [[Mitoxantrone]]
+* [[Omacetaxine]]
+* [[Procarbazine]]
+* [[Radium chloride]]
+* [[Romidepsin]]
+* [[Samarium (153Sm) lexidronam]]
+* [[Sulfasalazine]]
+*[[Teniposide]]
+* [[Thioguanine]]
 * [[Zidovudine]]
+==Natural History, Complications and Prognosis==
+The [[bone marrow]] is where blood cells are formed, and this process is slowed or stopped when bone marrow suppression is caused. This can rapidly lead to life-threatening [[infection]] as the body cannot produce [[leukocytes]] in response to invading [[bacterium|bacteria]] and [[viruses]], as well as anemia due to a lack of [[red blood cells]] and spontaneous severe bleeding due to deficiency of [[platelets]].
+==Treatment==
+Bone marrow suppression due to azathioprine can be treated by changing to another medication such as [[mycophenolate mofetil]] (for organ transplants) or other disease-modifying drugs in [[rheumatoid arthritis]] or [[Crohn's disease]]. Bone marrow suppression due to anti-cancer chemotherapy is much harder to treat and often involves hospital admission, strict infection control, and aggressive use of intravenous [[antibiotics]] at the first sign of infection.
+==References==
+{{Reflist|2}}
 [[Category:Hematology]]
-[[Category:Oncology]]
+[[Category:Immunology]]
-[[zh:骨髓抑制]]
 {{WikiDoc Help Menu}}
 {{WikiDoc Sources}}