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| {{DrugProjectFormSinglePage
| | #REDIRECT [[Asenapine maleate]] |
| |authorTag={{SG}}
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| |blackBoxWarningTitle=<b><span style="color:#FF0000;">TITLE</span></b>
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| |blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content)
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| |offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Asenapine in adult patients.
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| |offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Asenapine in adult patients.
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| |offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Asenapine in pediatric patients.
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| |offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Asenapine in pediatric patients.
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| |alcohol=Alcohol-Asenapine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
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| }}
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| {{drugbox
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| | IUPAC_name = (3a''S'',12b''S'')-5-Chloro-2,3,3a,12b-tetrahydro-<br>2-methyl-1''H''-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
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| | image = Asenapine.png
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| | CAS_number = 65576-45-6
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| | ATC_prefix =
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| | ATC_suffix =
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| | PubChem = 163091
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| | DrugBank =
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| | C = 17 | H = 16 | Cl = 1 | N = 1 | O = 1
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| | molecular_weight = 285.77 g/mol
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| | bioavailability =
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| | protein_bound =
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| | metabolism =
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| | elimination_half-life =
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| | excretion =
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| | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
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| | pregnancy_US = <!-- A / B / C / D / X -->
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| | pregnancy_category=
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| | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
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| | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
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| | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
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| | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
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| | legal_status =
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| | routes_of_administration =
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| }}
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| '''Asenapine''' is a new [[5-HT2A receptor|5-HT<sub>2A</sub>-]] and [[dopamine receptor|D2-receptor]] [[antagonist]] under development for the treatment of [[schizophrenia]] and acute mania associated with [[bipolar disorder]] by [[Schering-Plough]] after its [[November 19]], [[2007]] combination with [[Organon International]]. Development of the drug, through [[Phase III]] trials, began while Organon was still a part of [[Akzo Nobel]].<ref name="GEN200706">{{cite news
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| | title = Bipolar Disorder | work = Clinical Trials Update
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| | publisher = Genetic Engineering & Biotechnology News | pages = 52,55 | date = 2007-06-15 | accessdate = 2007-12-16
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| }}</ref> Preliminary data indicate that it has minimal anticholinergic and cardiovascular side effects, as well as minimal weight gain. Over 3000 patients have participated in [[clinical trial]]s of asenapine, and the [[Food and Drug Administration|FDA]] accepted the manufacturer's [[New Drug Application|NDA]] on [[November 26]], [[2007]] for standard review. <ref>{{cite press release
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| | title = Schering-Plough Announces Asenapine NDA Accepted for Filing by the U.S. FDA
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| | publisher = Schering-Plough
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| | date = [[2007-11-26]]
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| | url = http://www.schering-plough.com/schering_plough/news/release.jsp?releaseID=1080771
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| | accessdate = 2007-11-26 }})</ref>
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| Asenapine belongs to a class of neuroleptics known as "[[atypical antipsychotics]]", which have, over the last two decades, become increasingly popular alternatives to "[[typical antipsychotics]]", such as [[haloperidol]]. The manufacturers of asanapine refer to it as a "new generation" or "second generation" atypical antipsychotic.
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| Other atypical antipsychotics include [[aripiprazole]], [[olanzapine]], [[quetiapine]], [[risperidone]], and [[ziprasidone]].
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| ==Notes==
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| {{reflist|2}}
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| ==External links==
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| ===Commercial===
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| * [http://www.organon.com/ Organon website]
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| ===Third-party===
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| * [http://www.medicalnewstoday.com/medicalnews.php?newsid=57683 Organon Continues With The Development Of Asenapine For Schizophrenia And Acute Mania Associated With Bipolar I Disorder]
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| [[Category:Receptor modulators]]
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| {{Antipsychotics}}
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| <!--Categories-->
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| [[Category:Atypical antipsychotics]]
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| {{pharma-stub}}
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