Toxic epidermal necrolysis causes: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Toxic epidermal necrolysis}} | {{Toxic epidermal necrolysis}} | ||
{{CMG}}; {{AE}} | |||
==Overview== | ==Overview== | ||
Toxic epidermal necrolysis is a rare and usually severe adverse reaction to certain drugs. History of medication use exists in over 95% of patients with TEN. The drugs most often implicated in TEN are antibiotics such as sulfonamides, [[nonsteroidal anti-inflammatory drugs]], [[allopurinol]], [[antiretroviral drugs]], [[corticosteroids]] and [[anticonvulsant]]s such as [[phenobarbital]], [[phenytoin]], [[carbamazepine]], and [[valproic acid]]. The condition might also result from immunizations, infection with agents such as ''[[Mycoplasma pneumoniae]]'' or [[herpes virus]] and [[Organ transplant|transplant]]s of [[bone marrow]] or organs. | Toxic epidermal necrolysis is a rare and usually severe adverse reaction to certain drugs. History of medication use exists in over 95% of patients with TEN. The drugs most often implicated in TEN are antibiotics such as sulfonamides, [[nonsteroidal anti-inflammatory drugs]], [[allopurinol]], [[antiretroviral drugs]], [[corticosteroids]] and [[anticonvulsant]]s such as [[phenobarbital]], [[phenytoin]], [[carbamazepine]], and [[valproic acid]]. The condition might also result from immunizations, infection with agents such as ''[[Mycoplasma pneumoniae]]'' or [[herpes virus]] and [[Organ transplant|transplant]]s of [[bone marrow]] or organs. | ||
==Causes== | ==Causes== | ||
===Life-threatening Causes=== | |||
*Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of [[disease name]], however complications resulting from untreated [[disease name]] is common. | |||
*Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3]. | |||
*[Cause] is a life-threatening cause of [disease]. | |||
===Common Causes=== | |||
Common causes of [disease name] may include: | |||
*[Cause1] | |||
*[Cause2] | |||
*[Cause3] | |||
OR | |||
*[Disease name] is caused by an infection with [pathogen name]. | |||
*[Pathogen name] is caused by [pathogen name]. | |||
===Less Common Causes=== | |||
Less common causes of [disease name] include: | |||
*[Cause1] | |||
*[Cause2] | |||
*[Cause3] | |||
===Genetic Causes=== | |||
*[Disease name] is caused by a mutation in the [gene name] gene. | |||
===Causes by Organ System=== | |||
{|style="width:80%; height:100px" border="1" | |||
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular''' | |||
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes | |||
|- | |||
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Dental''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Dermatologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Drug Side Effect''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Ear Nose Throat''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Endocrine''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Environmental''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Gastroenterologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Genetic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Hematologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Iatrogenic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Infectious Disease''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Musculoskeletal/Orthopedic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Neurologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Nutritional/Metabolic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Obstetric/Gynecologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Oncologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Ophthalmologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Overdose/Toxicity''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Psychiatric''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Pulmonary''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Renal/Electrolyte''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Rheumatology/Immunology/Allergy''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Sexual''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Trauma''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Urologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Miscellaneous''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|} | |||
===Causes in Alphabetical Order=== | |||
Drug Side Effects | Drug Side Effects | ||
* [[Acetaminophen]] | * [[Acetaminophen]] | ||
Line 14: | Line 156: | ||
* [[Amoxycillin]] | * [[Amoxycillin]] | ||
* [[Aztreonam]] | * [[Aztreonam]] | ||
* [[Butalbital]] | |||
* [[Cefadroxil]] | * [[Cefadroxil]] | ||
* [[Cefaclor]] | * [[Cefaclor]] | ||
* [[Ceftibuten]] | |||
* [[Cefotaxime sodium]] | * [[Cefotaxime sodium]] | ||
* [[Cefotetan disodium]] | |||
* [[Ceftazidime]] | * [[Ceftazidime]] | ||
* [[Certolizumab pegol]] | |||
* [[Cladribine]] | * [[Cladribine]] | ||
* [[Clobazam]] | * [[Clobazam]] | ||
* [[clofarabine]] | |||
*[[Cysteamine]] | |||
* [[Cytarabine]] | * [[Cytarabine]] | ||
* [[Dactinomycin]] | * [[Dactinomycin]] | ||
* [[diclofenac (patch)]] | |||
* [[Doripenem]] | |||
* [[Etravirine]] | |||
* [[Flurbiprofen]] | * [[Flurbiprofen]] | ||
*[[Idelalisib]] | |||
* [[Piperacillin/tazobactam]] | |||
*[[Pralatrexate]] | |||
* [[Lacosamide]] | * [[Lacosamide]] | ||
* [[Rifampin]] | * [[Rifampin]] | ||
* [[Ritonavir]] | * [[Ritonavir]] | ||
* [[Ibritumomab tiuxetan]] | |||
* [[Isotretinoin]] | * [[Isotretinoin]] | ||
* [[Meropenem]] | * [[Meropenem]] | ||
*[[Oxaprozin]] | |||
* [[Terconazole]] | * [[Terconazole]] | ||
* [[[[Tolmetin]] | |||
* [[Piperacillin]] | * [[Piperacillin]] | ||
* [[Sorafenib]] | * [[Sorafenib]] | ||
* [[Spironolactone]] | * [[Spironolactone]] | ||
* [[Sulfasalazine]] | * [[Sulfasalazine]] | ||
* [[Sulfacetamide]] | |||
* [[Sulfamethoxazole/Trimethoprim (oral)]] | |||
* [[Trovafloxacin mesylate]] | |||
* [[Valdecoxib]], | |||
==References== | ==References== | ||
{{ | {{Reflist|2}} | ||
{{ | {{WH}} | ||
{{ | {{WS}} | ||
[[Category: (name of the system)]] |
Latest revision as of 15:57, 15 August 2018
Toxic epidermal necrolysis Microchapters |
Differentiating Toxic Epidermal Necrolysis from other Diseases |
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Diagnosis |
Treatment |
Case Studies |
Toxic epidermal necrolysis causes On the Web |
American Roentgen Ray Society Images of Toxic epidermal necrolysis causes |
Risk calculators and risk factors for Toxic epidermal necrolysis causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Toxic epidermal necrolysis is a rare and usually severe adverse reaction to certain drugs. History of medication use exists in over 95% of patients with TEN. The drugs most often implicated in TEN are antibiotics such as sulfonamides, nonsteroidal anti-inflammatory drugs, allopurinol, antiretroviral drugs, corticosteroids and anticonvulsants such as phenobarbital, phenytoin, carbamazepine, and valproic acid. The condition might also result from immunizations, infection with agents such as Mycoplasma pneumoniae or herpes virus and transplants of bone marrow or organs.
Causes
Life-threatening Causes
- Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of disease name, however complications resulting from untreated disease name is common.
- Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
- [Cause] is a life-threatening cause of [disease].
Common Causes
Common causes of [disease name] may include:
- [Cause1]
- [Cause2]
- [Cause3]
OR
- [Disease name] is caused by an infection with [pathogen name].
- [Pathogen name] is caused by [pathogen name].
Less Common Causes
Less common causes of [disease name] include:
- [Cause1]
- [Cause2]
- [Cause3]
Genetic Causes
- [Disease name] is caused by a mutation in the [gene name] gene.
Causes by Organ System
Cardiovascular | No underlying causes |
Chemical/Poisoning | No underlying causes |
Dental | No underlying causes |
Dermatologic | No underlying causes |
Drug Side Effect | No underlying causes |
Ear Nose Throat | No underlying causes |
Endocrine | No underlying causes |
Environmental | No underlying causes |
Gastroenterologic | No underlying causes |
Genetic | No underlying causes |
Hematologic | No underlying causes |
Iatrogenic | No underlying causes |
Infectious Disease | No underlying causes |
Musculoskeletal/Orthopedic | No underlying causes |
Neurologic | No underlying causes |
Nutritional/Metabolic | No underlying causes |
Obstetric/Gynecologic | No underlying causes |
Oncologic | No underlying causes |
Ophthalmologic | No underlying causes |
Overdose/Toxicity | No underlying causes |
Psychiatric | No underlying causes |
Pulmonary | No underlying causes |
Renal/Electrolyte | No underlying causes |
Rheumatology/Immunology/Allergy | No underlying causes |
Sexual | No underlying causes |
Trauma | No underlying causes |
Urologic | No underlying causes |
Miscellaneous | No underlying causes |
Causes in Alphabetical Order
Drug Side Effects
- Acetaminophen
- Amifostine
- Amoxycillin
- Aztreonam
- Butalbital
- Cefadroxil
- Cefaclor
- Ceftibuten
- Cefotaxime sodium
- Cefotetan disodium
- Ceftazidime
- Certolizumab pegol
- Cladribine
- Clobazam
- clofarabine
- Cysteamine
- Cytarabine
- Dactinomycin
- diclofenac (patch)
- Doripenem
- Etravirine
- Flurbiprofen
- Idelalisib
- Piperacillin/tazobactam
- Pralatrexate
- Lacosamide
- Rifampin
- Ritonavir
- Ibritumomab tiuxetan
- Isotretinoin
- Meropenem
- Oxaprozin
- Terconazole
- [[Tolmetin
- Piperacillin
- Sorafenib
- Spironolactone
- Sulfasalazine
- Sulfacetamide
- Sulfamethoxazole/Trimethoprim (oral)
- Trovafloxacin mesylate