Bone marrow suppression: Difference between revisions

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VisualWikitext

Latest revision as of 14:51, 17 August 2015

For congenital bone marrow suppression click here.
For acquired bone marrow suppression click here.
For the main page of bone marrow disorders click here.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Rim Halaby, M.D. [2]; Serge Korjian M.D.

Synonyms and keywords: Bone marrow failure, bone marrow depression, myelosuppression, myelosuppressive disorder

Overview

Bone marrow suppression is the reduction in numbers of cells in the bone marrow, that can be either congenital or acquired. Acquired bone marrow suppression may be any of the following: 1) myelosuppression characterized by a reduction in the number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes), or 2) immunosuppression characterized by a reduction in the number of lymphoid lineage cells (T-cell, B-cell, NK cell). Bone marrow suppression can be a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine. NSAIDs may also cause bone marrow suppression. The risk is especially high in chemotherapy for leukemia.

Classification

Shown below is an algorthim that depicts the classification of bone marrow suppression. For congenital bone marrow suppression click here. For acquired bone marrow suppression click here.

Myelodysplasia

All hematopoietic lineages

Aplastic anemia (aplastic pancytopenia)

Paroxysmal nocturnal hemoglobinuria (PNH)

Myelosuppression

Pure red cell aplasia (erythroblastopenia)

One lineage

Neutropenia (granulocytopenia and agranulocytosis)

Acquired bone marrow suppression

Amegakaryocytic thrombocytopenia

T-cell immunosuppression

Immunosuppression

B-cell immunosuppression

Bone Marrow Suppression

NK cell immunosuppression

Multiple lineages

Congenital bone marrow suppression

One lineage

Causes

Drug Side Effects

Natural History, Complications and Prognosis

The bone marrow is where blood cells are formed, and this process is slowed or stopped when bone marrow suppression is caused. This can rapidly lead to life-threatening infection as the body cannot produce leukocytes in response to invading bacteria and viruses, as well as anemia due to a lack of red blood cells and spontaneous severe bleeding due to deficiency of platelets.

Treatment

Bone marrow suppression due to azathioprine can be treated by changing to another medication such as mycophenolate mofetil (for organ transplants) or other disease-modifying drugs in rheumatoid arthritis or Crohn's disease. Bone marrow suppression due to anti-cancer chemotherapy is much harder to treat and often involves hospital admission, strict infection control, and aggressive use of intravenous antibiotics at the first sign of infection.

References

Template:WikiDoc Sources

@@ Line 1: / Line 1: @@
+__NOTOC__
+'''''For congenital bone marrow suppression click [[congenital bone marrow disorders#Inherited Bone Marrow Failure Syndromes|here]].'''''<br>
+'''''For acquired bone marrow suppression click [[acquired bone marrow disorders#Bone Marrow Suppression|here]].'''''<br>
+'''''For the main page of bone marrow disorders click [[bone marrow disorders|here]].'''''
 {{SI}}
-{{CMG}}
+{{CMG}}; {{AE}} {{YD}}; {{Rim}}; {{SSK}}
+{{SK}} Bone marrow failure, bone marrow depression, myelosuppression, myelosuppressive disorder
 ==Overview==
-'''Bone marrow suppression''' is a serious side effect of [[chemotherapy]] and certain drugs affecting the immune system such as [[azathioprine]]. NSAIDS may also cause bone marrow suppression. The risk is especially high in chemotherapy for [[leukemia|leukaemia]].
+Bone marrow suppression is the reduction in numbers of cells in the [[bone marrow]], that can be either congenital or acquired.  Acquired bone marrow suppression may be any of the following: 1) myelosuppression characterized by a reduction in the number of [[myeloid]] lineage cells ([[RBC]], [[neutrophils]], [[basophils]], [[eosinophils]], [[monocyte]]s, [[platelets]], [[mastocytes]]), or 2) immunosuppression characterized by a reduction in the number of [[lymphoid]] lineage cells ([[T-cell]], [[B-cell]], [[NK cell]]). Bone marrow suppression can be a serious side effect of [[chemotherapy]] and certain drugs affecting the immune system such as [[azathioprine]]. [[NSAID]]s may also cause bone marrow suppression. The risk is especially high in chemotherapy for [[leukemia]].
-The [[bone marrow]] is where blood cells are formed, and this process is slowed or stopped when bone marrow suppression is caused. This can rapidly lead to life-threatening [[infection]] as the body cannot produce [[leukocytes]] in response to invading [[bacterium|bacteria]] and [[viruses]], as well as anaemia due to a lack of [[red blood cells]] and spontaneous severe bleeding due to deficiency of [[platelets]].
+==Classification==
+Shown below is an algorthim that depicts the classification of bone marrow suppression.  For congenital bone marrow suppression click [[congenital bone marrow disorders#Inherited Bone Marrow Failure Syndromes|here]].  For acquired bone marrow suppression click [[acquired bone marrow disorders#Bone Marrow Suppression|here]].
-Bone marrow suppression due to azathioprine can be treated by changing to another medication such as [[mycophenolate mofetil]] (for organ transplants) or other disease-modifying drugs in [[rheumatoid arthritis]] or [[Crohn's disease]]. Bone marrow suppression due to anti-cancer chemotherapy is much harder to treat and often involves hospital admission, strict infection control, and aggressive use of intravenous [[antibiotics]] at the first sign of infection.
+{{Family tree/start}}
+{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | | | | | | | | | | | |,| D01 | | | | | | | | D01= [[Myelodysplasia]]}}
-===Causes===
+{{Family tree | | | | | | | | | | | | | |!| | | | | | | | | | }}
+{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | | | | | | | |,| C01 |+| D02 | | | | | | | | C01= All hematopoietic lineages| D02= [[Aplastic anemia]] ([[aplastic pancytopenia]])}}
+{{Family tree | | | | | | | | | |!| | | |!| | | | | | | | | | }}
-===Drug Side Effect===
+{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | | | | | | | |!| | | |`| D03 | | | | | | | | D03= [[Paroxysmal nocturnal hemoglobinuria]] ([[PNH]])}}
+{{Family tree |boxstyle= padding: 0; background: #66CDAA; | | | | | |,| B01 |(| | | | | | | | | | | | | | | B01= Myelosuppression}}
+{{Family tree |boxstyle= padding: 0; background: #A9A9A9; | | | | | |!| | | |!| | | |,| D04 | | | | | | | | D04= [[Pure red cell aplasia]] ([[erythroblastopenia]])}}
+{{Family tree | | | | | |!| | | |!| | | |!| | | | | | | | | | }}
+{{Family tree |boxstyle= padding: 0; background: #A9A9A9; | | | | | |!| | | |`| C02 |+| D05 | | | | | | | | C02= One lineage|D05= [[Neutropenia]] ([[granulocytopenia]] and [[agranulocytosis]])}}
+{{Family tree |boxstyle= padding: 0; background: #FFA07A; | | | |,| A01 | | | | | | |!| | | | | | | | | | A01= '''[[Acquired bone marrow suppression]]''' }}
+{{Family tree |boxstyle= padding: 0; background: #A9A9A9; | | | |!| |!| | | | | | | |`| D06 | | | | | | | | D06= [[Amegakaryocytic thrombocytopenia]]}}
+{{Family tree |boxstyle= padding: 0; background: #FAEBD7; | | | |!| |!| | | |,| C22 | | | | | | | | | | | | C22= [[T-cell immunosuppression]]}}
+{{Family tree |boxstyle= padding: 0; background: #66CDAA; | | | |!| |`| B11 |(| | | | | | | | | | | | | | | B11= [[Immunosuppression]]}}
+{{Family tree |boxstyle= padding: 0; background: #FAEBD7; | | | |!| | | | | |)| C23 | | | | | | | | | | | | C23= [[B-cell immunosuppression]]}}
+{{Family tree |boxstyle= padding: 0; background: #FFA07A; | | A00 | | | | | |!| | | | | | | | | | | | | | | A00= '''Bone Marrow Suppression'''}}
+{{Family tree |boxstyle= padding: 0; background: #FAEBD7; | | | |!| | | | | |`| C24 | | | | | | | | | | | | C24= [[ NK cell immunosuppression]]}}
+{{Family tree | | | |!| | | | | | | | | | | | | | | | | | | | | }}
+{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | |!| |,|-|-|-|-| B01 | | | | | | | | | | | | | | | | B01= Multiple lineages }}
+{{Family tree |boxstyle= padding: 0; background: #A9A9A9; | | | |!| |!| | | }}
+{{Family tree |boxstyle= padding: 0; background: #FFA07A; | | | |`| A01 | | | | | | | | | | | A01= '''[[Congenital bone marrow suppression]]''' }}
+{{Family tree |boxstyle= padding: 0; background: #A9A9A9; | | | | | |!| | | }}
+{{Family tree |boxstyle= padding: 0; background: #A9A9A9; | | | | | |`|-|-|-|-| B11 | | | | | | | | | | | | | | | | B11= One lineage}}
+{{Family tree/end}}
+==Causes==
+===Drug Side Effects===
 * [[Albendazole]]
 * [[Altretamine]]
@@ Line 23: / Line 49: @@
 * [[Cyclophosphamide]]
 * [[Dactinomycin]]
+* [[Daunorubicin liposome]]
+* [[Dexrazoxane]]
+* [[Diethylpropion]]
 * [[Ethosuximide]]
+* [[Fludarabine]]
+* [[Guanidine]]
 * [[Hydroxyurea (patient information)]]
+* [[Idarubicin hydrochloride]]
+* [[Imipenem-Cilastatin]]
+* [[Ixabepilone]]
 * [[Mercaptopurine]]
 * [[Mitomycin]]
+* [[Mitoxantrone]]
+* [[Omacetaxine]]
+* [[Procarbazine]]
+* [[Radium chloride]]
+* [[Romidepsin]]
+* [[Samarium (153Sm) lexidronam]]
 * [[Sulfasalazine]]
+*[[Teniposide]]
+* [[Thioguanine]]
 * [[Zidovudine]]
+==Natural History, Complications and Prognosis==
+The [[bone marrow]] is where blood cells are formed, and this process is slowed or stopped when bone marrow suppression is caused. This can rapidly lead to life-threatening [[infection]] as the body cannot produce [[leukocytes]] in response to invading [[bacterium|bacteria]] and [[viruses]], as well as anemia due to a lack of [[red blood cells]] and spontaneous severe bleeding due to deficiency of [[platelets]].
+==Treatment==
+Bone marrow suppression due to azathioprine can be treated by changing to another medication such as [[mycophenolate mofetil]] (for organ transplants) or other disease-modifying drugs in [[rheumatoid arthritis]] or [[Crohn's disease]]. Bone marrow suppression due to anti-cancer chemotherapy is much harder to treat and often involves hospital admission, strict infection control, and aggressive use of intravenous [[antibiotics]] at the first sign of infection.
+==References==
+{{Reflist|2}}
 [[Category:Hematology]]
-[[Category:Oncology]]
+[[Category:Immunology]]
-[[zh:骨髓抑制]]
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