Lipodystrophy: Difference between revisions
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==Overview== | ==Overview== | ||
'''Lipodystrophy''' is a medical condition characterized by abnormal or degenerative conditions of the body's [[adipose]] tissue. ("Lipo" is [[Latin]] for "fat" and "dystrophy" is Latin for "abnormal or degenerative condition".) A more specific term, [[lipoatrophy]] is used when describing the loss of fat from one area (usually the face). | '''Lipodystrophy''' is a medical condition characterized by abnormal or degenerative conditions of the body's [[adipose]] tissue. ("Lipo" is [[Latin]] for "fat" and "dystrophy" is Latin for "abnormal or degenerative condition".) A more specific term, [[lipoatrophy]] is used when describing the loss of fat from one area (usually the face). | ||
== Insulin injections == | ==Insulin injections== | ||
A lipodystrophy can be a lump or small dent in the [[skin]] that forms when a person keeps performing [[Injection (medicine)|injections]] in the same spot. These types of lipodystrophies are harmless. People who want to avoid them can do so by changing (rotating) the places where they perform injections. For people with [[diabetes mellitus|diabetes]], using purified [[insulin]]s may also help. | A lipodystrophy can be a lump or small dent in the [[skin]] that forms when a person keeps performing [[Injection (medicine)|injections]] in the same spot. These types of lipodystrophies are harmless. People who want to avoid them can do so by changing (rotating) the places where they perform injections. For people with [[diabetes mellitus|diabetes]], using purified [[insulin]]s may also help. | ||
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In some cases, rotation of the injection sites may not be enough to prevent lipodystrophy. | In some cases, rotation of the injection sites may not be enough to prevent lipodystrophy. | ||
== Antiretroviral drugs == | ==Antiretroviral drugs== | ||
Lipodystrophies can be a possible side effect of [[antiretroviral drug]]s such as [[Dolutegravir]], [[lamivudine]], [[Ritonavir]], [[Saquinavir mesylate]]. Other lipodystrophies manifest as [[lipid]] redistribution; with excess, or lack of, fat in various regions of the body. These include, but are not limited to, having sunken cheeks and/or "humps" on the back or back of the neck (also referred to as buffalo hump).<ref>[http://www.medicinenet.com/script/main/art.asp?articlekey=19678 Physical and Biochemical Changes in HIV Disease] Eric S. Daar, M.D. MedicineNet, Accessed 22 September 2007</ref> | Lipodystrophies can be a possible side effect of [[antiretroviral drug]]s such as [[Dolutegravir]], [[lamivudine]], [[Rilpivirine]], [[Ritonavir]], [[Saquinavir mesylate]]. Other lipodystrophies manifest as [[lipid]] redistribution; with excess, or lack of, fat in various regions of the body. These include, but are not limited to, having sunken cheeks and/or "humps" on the back or back of the neck (also referred to as buffalo hump).<ref>[http://www.medicinenet.com/script/main/art.asp?articlekey=19678 Physical and Biochemical Changes in HIV Disease] Eric S. Daar, M.D. MedicineNet, Accessed 22 September 2007</ref> | ||
== Hereditary | ==Hereditary form == | ||
Lipodystrophy can be caused by metabolic abnormalities due to genetic issues. These are often characterized by [[insulin resistance]] and are associated with [[Syndrome X (metabolic)|Syndrome X]]. | Lipodystrophy can be caused by metabolic abnormalities due to genetic issues. These are often characterized by [[insulin resistance]] and are associated with [[Syndrome X (metabolic)|Syndrome X]]. | ||
==See also== | ==See also== | ||
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* [http://www.thebody.com/lipo/index.html TheBody: The Lipoatrophy Resource Center] | * [http://www.thebody.com/lipo/index.html TheBody: The Lipoatrophy Resource Center] | ||
==References== | |||
{{reflist|2}} | |||
{{Lipid metabolism disorders}} | {{Lipid metabolism disorders}} | ||
[[Category:Endocrinology]] | |||
[[de:Lipodystrophie]] | [[de:Lipodystrophie]] | ||
[[nl:Lipodystrofie]] | [[nl:Lipodystrofie]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Latest revision as of 19:41, 22 July 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
| Lipodystrophy | |
| ICD-10 | E88.1 |
|---|---|
| ICD-9 | 272.6 |
| DiseasesDB | 30066 |
| MeSH | D008060 |
Overview
Lipodystrophy is a medical condition characterized by abnormal or degenerative conditions of the body's adipose tissue. ("Lipo" is Latin for "fat" and "dystrophy" is Latin for "abnormal or degenerative condition".) A more specific term, lipoatrophy is used when describing the loss of fat from one area (usually the face).
Insulin injections
A lipodystrophy can be a lump or small dent in the skin that forms when a person keeps performing injections in the same spot. These types of lipodystrophies are harmless. People who want to avoid them can do so by changing (rotating) the places where they perform injections. For people with diabetes, using purified insulins may also help.
One of the side-effects of lipodystrophy is the rejection of the injected medication, the slowing down of the absorption of the medication, or trauma that can cause bleeding that, in turn, will reject the medication. In either scenarios, the dosage of the medication, such as insulin for diabetics, becomes impossible to gauge correctly and the treatment of the disease for which the medication is administered is impaired thereby allowing the medical condition to worsen.
In some cases, rotation of the injection sites may not be enough to prevent lipodystrophy.
Antiretroviral drugs
Lipodystrophies can be a possible side effect of antiretroviral drugs such as Dolutegravir, lamivudine, Rilpivirine, Ritonavir, Saquinavir mesylate. Other lipodystrophies manifest as lipid redistribution; with excess, or lack of, fat in various regions of the body. These include, but are not limited to, having sunken cheeks and/or "humps" on the back or back of the neck (also referred to as buffalo hump).[1]
Hereditary form
Lipodystrophy can be caused by metabolic abnormalities due to genetic issues. These are often characterized by insulin resistance and are associated with Syndrome X.
See also
External links
References
- ↑ Physical and Biochemical Changes in HIV Disease Eric S. Daar, M.D. MedicineNet, Accessed 22 September 2007
Template:Lipid metabolism disorders