List of chemotherapeutic agents: Difference between revisions

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__NOTOC__
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{{SI}}
{{Seealso|Chemotherapy regimens}}
{{Seealso|Chemotherapy regimens}}
{{CMG}}; {{AE}} {{AV}}; {{AP}}
{{CMG}}; {{AE}} {{AV}}; {{Steven}}


==Overview==
==Overview==
This is a '''list of chemotherapeutic agents''' (also known as '''cytotoxic agents''') that are known to be of use in [[chemotherapy]] for [[cancer]].  This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision. Each drug is listed once (at present), though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing.
This is a '''list of chemotherapeutic agents''' that are known to be of use in [[chemotherapy]] for [[cancer]]. A full alphabetical listing is included after the categorical listing.


The agents in this list are often combined into [[chemotherapy regimens]] for polychemotherapy (combination chemotherapy). For example, the [[CHOP]] regimen consists of [[cyclophosphamide]], [[hydroxydaunorubicin]] (doxorubicin), [[vincristine]] (Oncovin), and prednisone.  
The agents in this list are often combined into [[chemotherapy regimens]] for polychemotherapy (combination chemotherapy).


Besides chemotherapy, medical oncology ([[pharmacotherapy]] for cancer) includes several noncytotoxic classes of therapy, such as [[hormonal therapy (oncology)|hormonal therapy]] and [[targeted therapy]] (biologic therapy). Those agents are described in the relevant articles.
== Chemotherapeutic Agents by Category ==


== Chemotherapeutic Agents by Category ==
=== Alkylating agents ===


{{button|Cytotoxic Chemotherapy}}
====== Nitrogen mustards ======
* [[Chlorambucil|Chlorambucil (Leukeran)]]
* [[Cyclophosphamide|Cyclophosphamide (Cytoxan)]]
* [[Estramustine |Estramustine  (Emcyt)]]
* [[Ifosfamide|Ifosfamide (Iflex)]]
* [[Melphalan|Melphalan (Alkeran)]]
* [[Mechlorethamine|Mechlorethamine (Mustargen)]]


===== Alkylating agents =====
====== Ethylenimines ======
*[[Estramustine|Estramustine (Emcyt)]]
* [[Thiotepa|Thiotepa (Tepadina)]]
*[[Procarbazine|Procarbazine (Matulane)]]


===== Anthracyclines =====
====== Methylhydrazines ======
*[[Idarubicin hydrochloride|Idarubicin (Idamycin)]]
* [[Procarbazine|Procarbazine (Matulane)]]


===== Antimetabolites =====
====== Alkylsulfonates ======
*[[Fluorouracil|Fluorouracil (Adrucil, Efudex)]]
* [[Busulfan|Busulfan (Myleran)]]


===== Antimitotic agent=====
====== Nitrosoureas ======
*[[Dexrazoxane]]
* [[Bendamustine|Bendamustine (Treanda)]]
* [[Carmustine|Carmustine (BiCNU)]]
* [[Lomustine|Lomustine (CeeNU)]]
* [[Streptozocin|Streptozocin (Zanosar)]]


===== DNA synthesis inhibitors =====
====== Triazenes ======
*[[Streptozocin|Streptozocin (Zanosar)]]
* [[Altretamine|Altretamine (Hexalen)]]
* [[Dacarbazine|Dacarbazine (Dtic-Dome)]]
* [[Temozolomide|Temozolomide (Temodar)]]


===== Microtubule inhibitors =====
====== Platinum coordination complexes ======
*[[Ixabepilone|Ixabepilone (Ixempra)]]
* [[Carboplatin|Carboplatin (Paraplatin)]]
* [[Cisplatin|Cisplatin (Platinol)]]
* [[Oxaliplatin|Oxaliplatin (Eloxatin)]]


===== Nitrogen mustards =====
----


===== Nitrosureas =====
=== Antimetabolites ===


===== Platinum agents =====
====== Folic acid analogs ======
* [[Methotrexate|Methotrexate (Mexate, Folex)]]
* [[Pemetrexed|Pemetrexed (Alimta)]]
* [[Pralatrexate|Pralatrexate (Folotyn)]]


===== Proteasome inhibitors =====
====== Pyrimidine analogs ======
* [[Azacytidine|Azacytidine (Vidaza)]]
* [[Capecitabine|Capecitabine (Xeloda)]]
* [[Cytarabine|Cytarabine (Cytosar)]]
* [[Decitabine|Decitabine (Dacogen)]]
* [[Floxuridine|Floxuridine (FUDR)]]
* [[Fluorouracil|Fluorouracil (Adrucil, Efudex)]]
* [[Gemcitabine|Gemcitabine (Gemzar)]]
* [[Raltitrexed|Raltitrexed (Tomudex)]]
 
====== Purine analogs ======
* [[Cladribine|Cladribine (Leustatin)]]
* [[Clofarabine|Clofarabine (Clolar)]]
* [[Fludarabine|Fludarabine (Fludara)]]
* [[Mercaptopurine|Mercaptopurine (Purinethol)]]
* [[Nelarabine|Nelarabine (Arranon)]]
* [[Pentostatin|Pentostatin (Nipent)]]
* [[Thioguanine|Thioguanine (Tabloid)]]
 
====== Ribonucleotide reductase inhibitors ======
* [[Hydroxyurea|Hydroxyurea (Hydrea)]]
 
----
 
=== Natural products ===
 
====== Vinca alkaloids ======
* [[Vinblastine|Vinblastine (Velban, Velsar)]]
* [[Vincristine|Vincristine (Oncovin, Vincasar)]]
* [[Vincristine liposome|Vincristine liposome (Marqibo)]]
* [[Vinflunine|Vinflunine (Javlor)]]
* [[Vinorelbine|Vinorelbine (Navelbine)]]
 
====== Taxanes ======
* [[Docetaxel|Docetaxel (Taxotere)]]
* [[Paclitaxel|Paclitaxel (Taxol, Onxol)]]
* [[Paclitaxel protein-bound|Paclitaxel protein-bound (Abraxane)]]


===== Taxanes =====
====== Epipodophyllotoxins ======
* [[Etoposide|Etoposide (Vespid)]]
* [[Teniposide|Teniposide (Vumon)]]


===== Topoisomerase inhibitors =====
====== Camptothecins ======
*[[Irinotecan hydrochloride|Irinotecan (Camptosar)]]
* [[Irinotecan|Irinotecan (Camptosar)]]
* [[Topotecan|Topotecan (Hycamtin)]]


===== Vinca alkaloids =====
====== Antineoplastic antibiotics ======
* [[Bleomycin|Bleomycin (Blenoxane)]]
* [[Dactinomycin|Dactinomycin (Cosmegen)]]
* [[Daunorubicin |Daunorubicin (Cerubidine)]]
* [[Daunorubicin liposome|Daunorubicin liposome (Daunoxome)]]
* [[Doxorubicin|Doxorubicin (Adriamycin, Rubex)]]
* [[Epirubicin|Epirubicin (Ellence)]]
* [[Idarubicin|Idarubicin (Idamycin)]]
* [[Mitomycin C|Mitomycin C (Mutamycin)]]
* [[Mitoxantrone|Mitoxantrone (Novantrone)]]
* [[Pixantrone|Pixantrone (Pixuvri)]]
* [[Plicamycin|Plicamycin (Mithracin)]]
* [[Valrubicin|Valrubicin (Valstar)]]


====== Antineoplastic enzymes ======
* [[L-Asparaginase|L-Asparaginase (Elspar)]]
* [[Pegaspargase|Pegaspargase (Oncaspar)]]
* [[Glucarpidase|Glucarpidase (Voraxaze)]]


----
----


{{Button|Endocrine therapy}}
=== Hormones and Antagonists ===
 
====== Adrenocortical suppressants ======
* [[Aminoglutethimide|Aminoglutethimide (Cytadren)]]
 
* [[Mitotane|Mitotane (Lysodren)]]
* [[Trilostane|Trilostane (Modrenal)]]
 
====== Glucocorticoids ======
* [[Dexamethasone|Dexamethasone (Decadron)]]
* [[Prednisone|Prednisone (Deltasone)]]
 
====== Progestins ======
* [[Medroxyprogesterone acetate|Medroxyprogesterone acetate (Provera)]]
* [[Megestrol|Megestrol (Megace)]]
 
====== Estrogens ======
* [[Esterified estrogens|Esterified estrogens (Menest)]]
 
====== Anti-estrogens ======
* [[Fulvestrant|Fulvestrant (Faslodex)]]
* [[Raloxifene|Raloxifene (Evista)]]
* [[Tamoxifen|Tamoxifen (Nolvadex)]]
* [[Toremifene|Toremifene (Fareston)]]


===== Antiandrogens =====
====== Aromatase inhibitors ======
* [[Anastrozole|Anastrozole (Arimidex)]]
* [[Exemestane|Exemestane (Aromasin)]]
* [[Formestane|Formestane (Lentaron)]]
* [[Letrozole|Letrozole (Femara)]]
 
====== Androgens ======
* [[Fluoxymesterone|Fluoxymesterone (Halotestin)]]
* [[Testolactone|Testolactone (Teslac)]]
 
====== Anti-androgens ======
* [[Abarelix|Abarelix (Plenaxis)]]
* [[Abiraterone|Abiraterone (Zytiga)]]
* [[Abiraterone|Abiraterone (Zytiga)]]
* [[Bicalutamide|Bicalutamide (Casodex)]]
* [[Bicalutamide|Bicalutamide (Casodex)]]
* [[Dutasteride|Dutasteride (Avodart)]]
* [[Enzalutamide|Enzalutamide (Xtandi)]]
* [[Enzalutamide|Enzalutamide (Xtandi)]]
* [[Finasteride|Finasteride (Proscar)]]
* [[Flutamide|Flutamide (Eulexin)]]  
* [[Flutamide|Flutamide (Eulexin)]]
* [[Ketoconazole|Ketoconazole (Nizoral)]]
* [[Leuprolide|Leuprolide (Lupron)]]
* [[Nilutamide|Nilutamide (Nilandron)]]
* [[Nilutamide|Nilutamide (Nilandron)]]
====== LHRH agonists ======
* [[Triptorelin|Triptorelin (Trelstar)]]
* [[Triptorelin|Triptorelin (Trelstar)]]


===== Steroid synthesis inhibitors =====
===== GnRH agonists =====
* [[Abiraterone|Abiraterone (Zytiga)]]
* [[Buserelin|Buserelin (Superfact)]]  
* [[Aminoglutethimide|Aminoglutethimide (Cytadren)]]
* [[Goserelin|Goserelin (Zoladex)]]
* [[Anastrozole|Anastrozole (Arimidex)]]
* [[Leuprolide|Leuprolide (Lupron)]]
* [[Exemestane|Exemestane (Aromasin)]]
 
* [[Letrozole|Letrozole (Femara)]]
===== GnRH antagonists =====
* [[Degarelix|Degarelix (Firmagon)]]
 
----
 
=== Biologics ===


===== Androgen receptor inhibitors =====
===== Monoclonal antibodies =====
*[[Nilutamide|Nilutamide (Nilandron)]]


===== -reductase inhibitors =====
====== Anti-CD3 antibodies ======
* [[Catumaxomab|Catumaxomab (Removab)]]


===== GnRH agonists =====
====== Anti-CD3 & anti-CD19 antibodies ======
* [[Buserelin|Buserelin (Superfact)]]
* [[Blinatumomab|Blinatumomab (Blincyto)]]


===== GnRH antagonists =====
====== Anti-CD20 antibodies ======
*[[Degarelix]]
* [[Rituximab|Rituximab (Rituxan)]]
* [[Ibritumomab tiuxetan|Ibritumomab tiuxetan (Zevalin))]]
* [[Obinutuzumab|Obinutuzumab (Gazyva)]]
* [[Ofatumumab|Ofatumumab (Arzerra)]]
* [[Tositumomab|Tositumomab (Bexxar)]]


===== Aromatase inhibitors =====
====== Anti-CD30 antibodies ======
* [[Brentuximab|Brentuximab (Adcetris)]]


===== Selective estrogen receptor modulators =====
====== Anti-CD33 antibodies ======
* [[Gemtuzumab|Gemtuzumab (Mylotarg)]]


----
====== Anti-CD52 antibodies ======
* [[Alemtuzumab|Alemtuzumab (Campath)]]


{{Button|Biologics}}
====== Anti-CTLA–4 antibodies ======
* [[Ipilimumab|Ipilimumab (Yervoy)]]


===== Antibody medications =====
====== Anti-EGFR (ErbB1) antibodies ======
*[[Ibritumomab tiuxetan]]
* [[Cetuximab|Cetuximab (Erbitux)]]
*[[Nivolumab |Nivolumab (Opdivo)]]
* [[Panitumumab|Panitumumab (Vectibix)]]
*[[Pembrolizumab|Pembrolizumab (KEYTRUDA)]]


===== Antibody-drug conjugates =====
====== Anti-PD–1 antibodies ======
*[[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]
* [[Nivolumab |Nivolumab (Opdivo)]]
* [[Pembrolizumab|Pembrolizumab (Keytruda)]]


===== Anti-HER2 medications =====
====== Anti-HER2/neu (ErbB2) antibodies ======
*[[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]
* [[Ado-trastuzumab emtansine|Ado-trastuzumab (Kadcyla)]]
*[[Trastuzumab|Trastuzumab (Herceptin)]]
* [[Pertuzumab|Pertuzumab (Perjeta)]]
* [[Trastuzumab|Trastuzumab (Herceptin)]]


===== Enzymes =====
====== Anti-VEGF antibodies ======
* [[Pegaspargase|Pegaspargase (Oncaspar)]]
* [[Bevacizumab|Bevacizumab (Avastin)]]
* [[Ramucirumab|Ramucirumab (Cyramza)]]


===== IL-6 inhibitors =====
===== IL-6 inhibitors =====
*[[Siltuximab|Siltuximab (Sylvant)]]
* [[Siltuximab|Siltuximab (Sylvant)]]
* [[Tocilizumab|Tocilizumab (Actemra)]]


===== IL-2 inhibitors =====
===== Immunotherapy =====
* [[Aldesleukin|Aldesleukin (Proleukin)]]
* [[Denileukin diftitox|Denileukin diftitox (Ontak)]]
* [[Denileukin diftitox|Denileukin diftitox (Ontak)]]
 
* [[Interferon alfa-2b|Interferon alfa-2b (Intron A)]]
===== Immunotherapy =====
* [[Peginterferon alfa-2a|Peginterferon alfa-2a (Pegasys)]]
 
* [[Pegylated interferon alfa-2b|Peginterferon alfa-2b (Sylatron)]]
===== Immunomodulatory drugs (IMiDs) =====
* [[Lenalidomide|Lenalidomide (Revlimid)]]
* [[Pomalidomide|Pomalidomide (Pomalyst)]]


----
----


{{Button|Hematopoietic Growth Factors}}
=== Hematopoietic Growth Factors ===


===== Erythrocyte growth factors =====
===== Erythrocyte growth factors =====
* [[Erythropoietin|Erythropoietin (Procrit)]]


===== Granulocyte growth factors =====
===== Granulocyte growth factors =====
*[[Filgrastim|Filgrastim (Granix)]]
* [[Filgrastim|Filgrastim (Neupogen)]]
*[[Sargramostim|Sargramostin (Leukine)]]
* [[Pegfilgrastim|Pegfilgrastim (Neulasta)]]
*[[Tbo-filgrastim|Tbo-filgrastim (Granix)]]
* [[Plerixafor|Plerixafor (Mozobil)]]
* [[Sargramostim|Sargramostin (Leukine, Leukomax)]]
* [[Tbo-filgrastim|Tbo-filgrastim (Granix)]]


===== Megakaryocyte growth factors =====
===== Megakaryocyte growth factors =====
* [[Eltrombopag|Eltrombopag (Promacta)]]
* [[Eltrombopag|Eltrombopag (Promacta)]]
* [[Romiplostim|Romiplostim (Nplate)]]
* [[Oprelvekin|Oprelvekin (Neumega)]]


----
----


{{Button|Supportive Medications}}
=== Supportive Medications ===


===== Chemotherapy protective agents =====
===== Chemotherapy protective agents =====
*[[Amifostine|Amifostine (Ethyol)]]
* [[Amifostine|Amifostine (Ethyol)]]
*[[Cyanocobalamin|Cyanocobalamin]]
* [[Cyanocobalamin|Cyanocobalamin (Cobal)]]
*[[Dexrazoxane|Dexrazoxane (Zinecard)]]
* [[Dexrazoxane|Dexrazoxane (Zinecard)]]
*[[Folinic acid|Folinic acid (Leucovorin)]]
* [[Folinic acid|Folinic acid (Leucovorin Calcium)]]
*[[Glucarpidase|Glucarpidase (Voraxaze)]]
* [[Glucarpidase|Glucarpidase (Voraxaze)]]
*[[Levoleucovorin|Levoleucovorin (Fusilev)]]
* [[Levoleucovorin|Levoleucovorin (Fusilev)]]
*[[Mesna|Mesna (Mesnex)]]
* [[Mesna|Mesna (Mesnex)]]
* [[Rasburicase|Rasburicase (Elitek)]]


===== Antiemetic agents =====
===== Antiemetic agents =====
*[[Netupitant and palonosetron |Netupitant and palonosetron (Akynzeo)]]
* [[Netupitant and palonosetron |Netupitant and palonosetron (Akynzeo)]]


===== RANK ligand inhibitors =====
===== RANK ligand inhibitors =====
* [[Denosumab|Denosumab (Xgeva)]]
* [[Denosumab|Denosumab (Xgeva)]]
===== Calcium regulators =====
* [[Gallium nitrate|Gallium nitrate (Ganite)]]
* [[Pamidronate|Pamidronate (Aredia)]]
* [[Zoledronic Acid|Zoledronic Acid (Zometa)]]


----
----


{{Button|Miscellaneous}}
=== Miscellaneous ===
 
===== Mitotic inhibitors =====
* [[Amsacrine|Amsacrine (Amsidine)]]
* [[Cabazitaxel|Cabazitaxel (Jevtana)]]
* [[Eribulin|Eribulin (Halaven)]]
* [[Ixabepilone|Ixabepilone (Ixempra)]]


===== HDAC inhibitors =====
===== HDAC inhibitors =====
Line 161: Line 292:
* [[Romidepsin|Romidepsin (Istodax)]]
* [[Romidepsin|Romidepsin (Istodax)]]
* [[Vorinostat|Vorinostat (Zolinza)]]
* [[Vorinostat|Vorinostat (Zolinza)]]
===== Hedgehog pathway inhibitors =====
* [[Vismodegib|Vismodegib (Erivedge)]]
===== Immunomodulatory drugs (IMiDs) =====
* [[Lenalidomide|Lenalidomide (Revlimid)]]
* [[Pomalidomide|Pomalidomide (Pomalyst)]]
* [[Sipuleucel-T|Sipuleucel-T (Provenge)]]
* [[Thalidomide|Thalidomide (Thalomid)]]


===== Kinase inhibitors =====
===== Kinase inhibitors =====
*[[Idelalisib|Idelalisib (Zydelig)]]
* [[Afatinib|Afatinib (Gliotrif)]]
*[[Palbociclib|Palbociclib (Ibrance)]]
* [[Axitinib|Axitinib (Inlyta)]]
* [[Bosutinib|Bosutinib (Bosulif)]]
* [[Cabozantinib|Cabozantinib (Cometriq)]]
* [[Ceritinib|Ceritinib (Zykadia)]]
* [[Crizotinib|Crizotinib (Xalkori)]]
* [[Dabrafenib|Dabrafenib (Tafinlar)]]
* [[Dasatinib|Dasatinib (Sprycel)]]
* [[Erlotinib|Erlotinib (Tarceva)]]
* [[Everolimus|Everolimus (Afinitor)]]
* [[Gefitinib|Gefitinib (Iressa)]]
* [[Ibrutinib|Ibrutinib (Imbruvica)]]
* [[Idelalisib|Idelalisib (Zydelig)]]
* [[Imatinib|Imatinib (Gleevec)]]
* [[Lapatinib|Lapatinib (Tykerb)]]
* [[Lenvatinib|Lenvatinib (Lenvima)]]
* [[Nilotinib|Nilotinib (Tasigna)]]
* [[Palbociclib|Palbociclib (Ibrance)]]
* [[Regorafenib|Regorafenib (Stivarga)]]
* [[Ruxolitinib|Ruxolitinib (Jakafi)]]
* [[Sorafenib|Sorafenib (Nexavar)]]
* [[Sunitinib|Sunitinib (Sutent)]]
* [[Temsirolimus|Temsirolimus (Torisel)]]
* [[Trametinib|Trametinib (Mekinist)]]
* [[Vandetanib|Vandetanib (Caprelsa)]]
* [[Vemurafenib|Vemurafenib (Zelboraf)]]
* [[Ziv-aflibercept|Ziv-aflibercept (Zaltrap)]]
 
===== Photosensitizing agents =====
* [[Aminolevulinic acid |Aminolevulinic acid (Levulan)]]
* [[Porfimer|Porfimer (Photofrin)]]
 
===== Proteasome inhibitors =====
* [[Bortezomib|Bortezomib (Velcade)]]
* [[Carfilzomib|Carfilzomib (Kyprolis)]]


===== Radioactive agents =====
* [[Radium-223 chloride|Radium-223 chloride (Xofigo)]]


===== VEGF receptor-2 antagonists =====
===== Somatostatin analogs =====
* [[Ramucirumab|Ramucirumab (Cyramza)]]
* [[Octreotide|Octreotide (Octreotide)]]
 
===== Differentiating agents =====
* [[Arsenic trioxide|Arsenic trioxide (Trisenox)]]
* [[Bexarotene|Bexarotene (Targretin)]]
* [[Tretinoin|Tretinoin (Vesanoid)]]


----
===== Orphan drugs =====
* [[Olaparib|Olaparib (Lynparza)]]
* [[Omacetaxine|Omacetaxine (Synribo)]]
* [[Ranpirnase|Ranpirnase (Onconase)]]
* [[Trabectedin|Trabectedin (Yondelis)]]


== Chemotherapeutic Agents in Alphabetical Order ==
== Chemotherapeutic Agents in Alphabetical Order ==
{{Columns-list|3|
* [[Abarelix|Abarelix (Plenaxis)]]
* [[Abiraterone|Abiraterone acetate (Zytiga)]]
* [[Abiraterone|Abiraterone acetate (Zytiga)]]
* [[Ado-trastuzumab|Ado-trastuzumab emtansine (Kadcyla)]]
* [[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]
* [[Afatinib|Afatinib (Gliotrif)]]
* [[Afatinib|Afatinib (Gliotrif)]]
* [[Aldesleukin|Aldesleukin (Proleukin)]]
* [[Aldesleukin|Aldesleukin (Proleukin)]]
* [[Alemtuzumab|Alemtuzumab (Campath)]]
* [[Altretamine|Altretamine (Hexalen)]]
* [[Altretamine|Altretamine (Hexalen)]]
* [[Amifostine|Amifostine (Ethyol)]]
* [[Amifostine|Amifostine (Ethyol)]]
* [[Aminoglutethimide|Aminoglutethimide (Cytadren)]]
* [[Aminolevulinic acid|Aminolevulinic acid (Levulan)]]
* [[Amsacrine|Amsacrine (Amsidine)]]
* [[Anastrozole|Anastrozole (Arimidex)]]
* [[Anastrozole|Anastrozole (Arimidex)]]
* [[Arsenic trioxide|Arsenic trioxide (Trisenox)]]
* [[Arsenic trioxide|Arsenic trioxide (Trisenox)]]
Line 191: Line 381:
* [[Bleomycin|Bleomycin (Blenoxane)]]
* [[Bleomycin|Bleomycin (Blenoxane)]]
* [[Blinatumomab|Blinatumomab (Blincyto)]]
* [[Blinatumomab|Blinatumomab (Blincyto)]]
* [[Bortezomib|Bortezomib (Velcade)]]
* [[Bosutinib|Bosutinib (Bosulif)]]
* [[Bosutinib|Bosutinib (Bosulif)]]
* [[Brentuximab vedotin|Brentuximab vedotin (Adcetris)]]
* [[Brentuximab vedotin|Brentuximab vedotin (Adcetris)]]
Line 201: Line 392:
* [[Carfilzomib|Carfilzomib (Kyprolis)]]
* [[Carfilzomib|Carfilzomib (Kyprolis)]]
* [[Carmustine|Carmustine (BiCNU)]]
* [[Carmustine|Carmustine (BiCNU)]]
* [[Catumaxomab|Catumaxomab (Removab)]]
* [[Ceritinib|Ceritinib (Zykadia)]]
* [[Ceritinib|Ceritinib (Zykadia)]]
* [[Cetuximab|Cetuximab (Erbitux)]]
* [[Cetuximab|Cetuximab (Erbitux)]]
* [[Chlorambucil|Chlorambucil (Leukeran)]]
* [[Chlorambucil|Chlorambucil (Leukeran)]]
* [[Cisplatin|Cisplatin (Platinol)]]
* [[Cisplatin|Cisplatin (Platinol)]]
* [[Cladribine|Cladribine (Leustatin)]]
* [[Clofarabine|Clofarabine (Clolar)]]
* [[Crizotinib|Crizotinib (Xalkori)]]
* [[Crizotinib|Crizotinib (Xalkori)]]
* [[Cyclophosphamide|Cyclophosphamide (Cytoxan)]]
* [[Cytarabine|Cytarabine (Cytosar)]]
* [[Cytarabine liposome|Cytarabine liposome (DepoCyt)]]
* [[Dabrafenib|Dabrafenib (Tafinlar)]]
* [[Dabrafenib|Dabrafenib (Tafinlar)]]
* [[Dacarbazine|Dacarbazine (Dtic-Dome)]]
* [[Dactinomycin|Dactinomycin (Cosmegen)]]
* [[Dasatinib|Dasatinib (Sprycel)]]
* [[Dasatinib|Dasatinib (Sprycel)]]
* [[Daunorubicin|Daunorubicin (Daunoxome)]]
* [[Daunorubicin|Daunorubicin (Cerubidine)]]
* [[Daunorubicin liposome|Daunorubicin liposome (Daunoxome)]]
* [[Decitabine|Decitabine (Dacogen)]]
* [[Decitabine|Decitabine (Dacogen)]]
* [[Degarelix|Degarelix (Firmagon)]]
* [[Degarelix|Degarelix (Firmagon)]]
Line 217: Line 417:
* [[Docetaxel|Docetaxel (Taxotere)]]
* [[Docetaxel|Docetaxel (Taxotere)]]
* [[Doxorubicin|Doxorubicin (Adriamycin, Rubex)]]
* [[Doxorubicin|Doxorubicin (Adriamycin, Rubex)]]
* [[Doxorubicin liposome|Doxorubicin liposome (Doxil, Lipodox)]]
* [[Enzalutamide|Enzalutamide (Xtandi)]]
* [[Enzalutamide|Enzalutamide (Xtandi)]]
* [[Epirubicin|Epirubicin (Ellence)]]
* [[Epirubicin|Epirubicin (Ellence)]]
Line 222: Line 423:
* [[Erlotinib|Erlotinib (Tarceva)]]
* [[Erlotinib|Erlotinib (Tarceva)]]
* [[Erythropoietin|Erythropoietin (Epogen, Procrit)]]
* [[Erythropoietin|Erythropoietin (Epogen, Procrit)]]
* [[Esterified estrogens|Esterified estrogens (Menest)]]
* [[Estramustine|Estramustine (Emcyt)]]
* [[Estramustine|Estramustine (Emcyt)]]
* [[Etoposide|Etoposide (Vespid)]]
* [[Etoposide|Etoposide (Vespid)]]
Line 233: Line 435:
* [[Flutamide|Flutamide (Eulexin)]]
* [[Flutamide|Flutamide (Eulexin)]]
* [[Folinic acid|Folinic acid (Leucovorin Calcium)]]
* [[Folinic acid|Folinic acid (Leucovorin Calcium)]]
* [[Formestane|Formestane (Lentaron)]]
* [[Fulvestrant|Fulvestrant (Faslodex)]]
* [[Fulvestrant|Fulvestrant (Faslodex)]]
* [[Gallium nitrate|Gallium Nitrate (Ganite)]]
* [[Gallium nitrate|Gallium Nitrate (Ganite)]]
* [[Gefitinib|Gefitinib (Iressa)]]
* [[Gemcitabine|Gemcitabine (Gemzar)]]
* [[Gemcitabine|Gemcitabine (Gemzar)]]
* [[Gemtuzumab ozogamicin|Gemtuzumab ozogamicin (Mylotarg)]]
* [[Gemtuzumab ozogamicin|Gemtuzumab ozogamicin (Mylotarg)]]
* [[Glucarpidase|Glucarpidase (Voraxaze)]]
* [[Glucarpidase|Glucarpidase (Voraxaze)]]
* [[Goserelin|Goserelin Acetate (Zoladex)]]
* [[Goserelin acetate|Goserelin Acetate (Zoladex)]]
* [[Hydroxyurea|Hydroxyurea (Hydrea)]]
* [[Hydroxyurea|Hydroxyurea (Hydrea)]]
* [[Ibritumomab tiuxetan|Ibritumomab tiuxetan (Zevalin)]]
* [[Ibritumomab tiuxetan|Ibritumomab tiuxetan (Zevalin)]]
Line 245: Line 449:
* [[Idelalisib|Idelalisib (Zydelig)]]
* [[Idelalisib|Idelalisib (Zydelig)]]
* [[Ifosfamide|Ifosfamide (Ifex)]]
* [[Ifosfamide|Ifosfamide (Ifex)]]
* [[interferon alfa-2b|interferon alfa-2b (Intron A)]]
* [[Imatinib|Imatinib (Gleevec)]]
* [[Interferon alfa-2b|Interferon alfa-2b (Intron A)]]
* [[Ipilimumab|Ipilimumab (Yervoy)]]
* [[Ipilimumab|Ipilimumab (Yervoy)]]
* [[Irinotecan|Irinotecan (Camptosar)]]
* [[Irinotecan|Irinotecan (Camptosar)]]
* [[Isotretinoin|Isotretinoin (Accutane)]]
* [[Ixabepilone|Ixabepilone (Ixempra)]]
* [[Ixabepilone|Ixabepilone (Ixempra)]]
* [[L-Asparaginase|L-Asparaginase (Elspar)]]
* [[L-Asparaginase|L-Asparaginase (Elspar)]]
Line 281: Line 485:
* [[Oxaliplatin|Oxaliplatin (Eloxatin)]]
* [[Oxaliplatin|Oxaliplatin (Eloxatin)]]
* [[Paclitaxel|Paclitaxel (Taxol, Onxol)]]
* [[Paclitaxel|Paclitaxel (Taxol, Onxol)]]
* [[Paclitaxel protein-bound|Paclitaxel protein-bound (Abraxane)]]
* [[Palbociclib|Palbociclib (Ibrance)]]
* [[Palbociclib|Palbociclib (Ibrance)]]
* [[Pamidronate|Pamidronate (Aredia)]]
* [[Pamidronate|Pamidronate (Aredia)]]
* [[Panitumumab|Panitumumab (Vectibix)]]
* [[Panitumumab|Panitumumab (Vectibix)]]
* [[Pazopanib|Pazopanib (Votrient)]]
* [[Pazopanib|Pazopanib (Votrient)]]
* [[Pegaspargase|PEG-Asparaginase (Oncaspar)]]
* [[Pegaspargase|Pegaspargase (Oncaspar)]]
* [[Pegfilgrastim|Pegfilgrastim (Neulasta)]]
* [[Pegfilgrastim|Pegfilgrastim (Neulasta)]]
* [[Peginterferon alfa-2a|Peginterferon alfa-2a (Pegasys)]]
* [[Pegylated interferon alfa-2b|Peginterferon alfa-2b (Sylatron)]]
* [[Pegylated interferon alfa-2b|Peginterferon alfa-2b (Sylatron)]]
* [[Pembrolizumab|Pembrolizumab (Keytruda)]]
* [[Pembrolizumab|Pembrolizumab (Keytruda)]]
Line 292: Line 498:
* [[Pentostatin|Pentostatin (Nipent)]]
* [[Pentostatin|Pentostatin (Nipent)]]
* [[Pertuzumab|Pertuzumab (Perjeta)]]
* [[Pertuzumab|Pertuzumab (Perjeta)]]
* [[Pixantrone|Pixantrone (Pixuvri)]]
* [[Plerixafor|Plerixafor (Mozobil)]]
* [[Plerixafor|Plerixafor (Mozobil)]]
* [[Plicamycin|Plicamycin (Mithracin)]]
* [[Pomalidomide|Pomalidomide (Pomalyst)]]
* [[Pomalidomide|Pomalidomide (Pomalyst)]]
* [[Ponatinib|Ponatinib (Iclusig)]]
* [[Ponatinib|Ponatinib (Iclusig)]]
* [[Porfimer|Porfimer (Photofrin)]]
* [[Pralatrexate|Pralatrexate (Folotyn)]]
* [[Pralatrexate|Pralatrexate (Folotyn)]]
* [[Prednisone|Prednisone (Deltasone)]]
* [[Prednisone|Prednisone (Deltasone)]]
* [[Procarbazine|Procarbazine (Matulane)]]
* [[Procarbazine|Procarbazine (Matulane)]]
* [[Radium-223 chloride|Radium-223 chloride (Xofigo)]]
* [[Radium-223 chloride|Radium-223 chloride (Xofigo)]]
* [[Raloxifene|Raloxifene (Evista)]]
* [[Raltitrexed|Raltitrexed (Tomudex)]]
* [[Ramucirumab|Ramucirumab (Cyramza)]]
* [[Ramucirumab|Ramucirumab (Cyramza)]]
* [[Ranpirnase|Ranpirnase (Onconase)]]
* [[Rasburicase|Rasburicase (Elitek)]]
* [[Rasburicase|Rasburicase (Elitek)]]
* [[Regorafenib|Regorafenib (Stivarga)]]
* [[Regorafenib|Regorafenib (Stivarga)]]
Line 316: Line 528:
* [[Temsirolimus|Temsirolimus (Torisel)]]
* [[Temsirolimus|Temsirolimus (Torisel)]]
* [[Teniposide|Teniposide (Vumon)]]
* [[Teniposide|Teniposide (Vumon)]]
* [[Testolactone|Testolactone (Teslac)]]
* [[Thalidomide|Thalidomide (Thalomid)]]
* [[Thalidomide|Thalidomide (Thalomid)]]
* [[Thioguanine|Thioguanine (Tabloid)]]
* [[Thioguanine|Thioguanine (Tabloid)]]
* [[Thiotepa|Thiotepa (TESPA)]]
* [[Thiotepa|Thiotepa (Tepadina)]]
* [[Tocilizumab|Tocilizumab (Actemra)]]
* [[Tocilizumab|Tocilizumab (Actemra)]]
* [[Topotecan|Topotecan (Hycamtin)]]
* [[Topotecan|Topotecan (Hycamtin)]]
* [[Toremifene|Toremifene (Fareston)]]
* [[Toremifene|Toremifene (Fareston)]]
* [[Tositumomab|Tositumomab (Bexxar)]]
* [[Trabectedin|Trabectedin (Yondelis)]]
* [[Trametinib|Trametinib (Mekinist)]]
* [[Trametinib|Trametinib (Mekinist)]]
* [[Trastuzumab|Trastuzumab (Herceptin)]]
* [[Trastuzumab|Trastuzumab (Herceptin)]]
* [[Tretinoin|Tretinoin (Vesanoid)]]
* [[Tretinoin|Tretinoin (Vesanoid)]]
* [[Triptorelin|Triptorelin (Trelstar)]]
* [[Trilostane|Trilostane (Modrenal)]]
* [[Triptorelin pamoate|Triptorelin pamoate (Trelstar)]]
* [[Valrubicin|Valrubicin (Valstar)]]
* [[Vandetanib|Vandetanib (Caprelsa)]]
* [[Vandetanib|Vandetanib (Caprelsa)]]
* [[Vemurafenib|Vemurafenib (Zelboraf)]]
* [[Vemurafenib|Vemurafenib (Zelboraf)]]
* [[Vinblastine|Vinblastine (Velban, Velsar)]]
* [[Vinblastine|Vinblastine (Velban, Velsar)]]
* [[Vincristine|Vincristine (Oncovin, Vincasar)]]
* [[Vincristine|Vincristine (Oncovin, Vincasar)]]
* [[Vincristine liposomal|Vincristine liposomal (Marqibo)]]
* [[Vincristine liposome|Vincristine liposome (Marqibo)]]
* [[Vinflunine|Vinflunine (Javlor)]]
* [[Vinorelbine|Vinorelbine (Navelbine)]]
* [[Vinorelbine|Vinorelbine (Navelbine)]]
* [[Vismodegib|Vismodegib (Erivedge)]]
* [[Vismodegib|Vismodegib (Erivedge)]]
Line 336: Line 554:
* [[Ziv-aflibercept|Ziv-aflibercept (Zaltrap)]]
* [[Ziv-aflibercept|Ziv-aflibercept (Zaltrap)]]
* [[Zoledronic acid|Zoledronic Acid (Zometa)]]
* [[Zoledronic acid|Zoledronic Acid (Zometa)]]
}}


[[Category:Chemotherapeutic agents|Chemotherapeutic agents]]
[[Category:Chemotherapeutic agents| ]]

Latest revision as of 04:08, 22 March 2015

Template:Seealso Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]; Steven Bellm, M.D. [3]

Overview

This is a list of chemotherapeutic agents that are known to be of use in chemotherapy for cancer. A full alphabetical listing is included after the categorical listing.

The agents in this list are often combined into chemotherapy regimens for polychemotherapy (combination chemotherapy).

Chemotherapeutic Agents by Category

Alkylating agents

Nitrogen mustards
Ethylenimines
Methylhydrazines
Alkylsulfonates
Nitrosoureas
Triazenes
Platinum coordination complexes

Antimetabolites

Folic acid analogs
Pyrimidine analogs
Purine analogs
Ribonucleotide reductase inhibitors

Natural products

Vinca alkaloids
Taxanes
Epipodophyllotoxins
Camptothecins
Antineoplastic antibiotics
Antineoplastic enzymes

Hormones and Antagonists

Adrenocortical suppressants
Glucocorticoids
Progestins
Estrogens
Anti-estrogens
Aromatase inhibitors
Androgens
Anti-androgens
LHRH agonists
GnRH agonists
GnRH antagonists

Biologics

Monoclonal antibodies
Anti-CD3 antibodies
Anti-CD3 & anti-CD19 antibodies
Anti-CD20 antibodies
Anti-CD30 antibodies
Anti-CD33 antibodies
Anti-CD52 antibodies
Anti-CTLA–4 antibodies
Anti-EGFR (ErbB1) antibodies
Anti-PD–1 antibodies
Anti-HER2/neu (ErbB2) antibodies
Anti-VEGF antibodies
IL-6 inhibitors
Immunotherapy

Hematopoietic Growth Factors

Erythrocyte growth factors
Granulocyte growth factors
Megakaryocyte growth factors

Supportive Medications

Chemotherapy protective agents
Antiemetic agents
RANK ligand inhibitors
Calcium regulators

Miscellaneous

Mitotic inhibitors
HDAC inhibitors
Hedgehog pathway inhibitors
Immunomodulatory drugs (IMiDs)
Kinase inhibitors
Photosensitizing agents
Proteasome inhibitors
Radioactive agents
Somatostatin analogs
Differentiating agents
Orphan drugs

Chemotherapeutic Agents in Alphabetical Order

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