Chlorcyclizine: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
No edit summary
 
(4 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{DrugProjectFormSinglePage
{{DrugProjectFormSinglePage
|authorTag=<!--Overview-->
|authorTag=<!--Overview-->{{RB}}
|OTC=Yes
|genericName=Chlorcyclizine
|aOrAn=a
|aOrAn=a
|drugClass=[[antihistamine]]
|indicationType=treatment
|indicationType=treatment
|hasBlackBoxWarning=Yes
|indication=[[hay fever]] or other [[upper respiratory allergies]]
|adverseReactions=<!--Black Box Warning-->
|adverseReactions=[[excitability]], [[drowsiness]]
 
 
<!--Black Box Warning-->
|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>


* Content
 


<!--Adult Indications and Dosage-->
<!--Adult Indications and Dosage-->


<!--FDA-Labeled Indications and Dosage (Adult)-->
<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult======Condition1=====
|fdaLIADAdult=====Indications====
 
* temporarily relieves these symptoms due to [[hay fever]] or other [[upper respiratory allergies]]:
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
* Dosing Information
 
:* Dosage
 
=====Condition3=====
 
* Dosing Information
 
:* Dosage
 
=====Condition4=====
 
* Dosing Information
 
:* Dosage
 
<!--Off-Label Use and Dosage (Adult)-->
 
<!--Guideline-Supported Use (Adult)-->
|offLabelAdultGuideSupport======Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information


:* Dosage
:* [[runny nose]]
:* [[sneezing]]
:* [[itching]] of the nose or throat
:* itchy, [[watery eyes]]


=====Condition2=====
====Directions====
* Do not exceed recommended dosage.


There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
: [[File:Chlorcyclizine Dosage.png|none|500px]]
|offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.


<!--Non–Guideline-Supported Use (Adult)-->
<!--Non–Guideline-Supported Use (Adult)-->
|offLabelAdultNoGuideSupport======Condition1=====
|offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.


<!--Pediatric Indications and Dosage-->
<!--Pediatric Indications and Dosage-->


<!--FDA-Labeled Indications and Dosage (Pediatric)-->
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
|fdaLIADPed======Condition1=====
|fdaLIADPed=====Directions====
 
* Do not exceed recommended dosage.
* Dosing Information


:* Dosage
: [[File:Chlorcyclizine Dosage.png|none|500px]]
 
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
=====Condition2=====
 
There is limited information regarding <i>FDA-Labeled Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Off-Label Use and Dosage (Pediatric)-->
 
<!--Guideline-Supported Use (Pediatric)-->
|offLabelPedGuideSupport======Condition1=====
 
* Developed by:
 
* Class of Recommendation:
 
* Strength of Evidence:
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.


<!--Non–Guideline-Supported Use (Pediatric)-->
<!--Non–Guideline-Supported Use (Pediatric)-->
|offLabelPedNoGuideSupport======Condition1=====
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
 
* Dosing Information
 
:* Dosage
 
=====Condition2=====
 
There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.


<!--Contraindications-->
<!--Contraindications-->
|contraindications=* Condition1
|contraindications=<!--Warnings-->
 
|warnings=* Do not exceed recommended dosage.
<!--Warnings-->
|warnings=* Description
 
====Precautions====
 
* Description
 
<!--Adverse Reactions-->
 
<!--Clinical Trials Experience-->
|clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label.
 
=====Body as a Whole=====
 
 
 
 
=====Cardiovascular=====
 
 
 
 
=====Digestive=====
 
 
 
 
=====Endocrine=====
 
 
 
 
=====Hematologic and Lymphatic=====
 
 
 
 
=====Metabolic and Nutritional=====
 
 
 
 
=====Musculoskeletal=====
 
 
 
 
=====Neurologic=====
 
 
 
 
=====Respiratory=====
 
 
 
 
=====Skin and Hypersensitivy Reactions=====


* Do not take this product unless directed by a doctor if you have


: a breathing problem such as [[emphysema]] or [[chronic bronchitis]]
: [[glaucoma]]
: [[difficulty in urination]] due to enlargement of the [[prostate gland]]
* Ask a doctor before use if you are taking sedatives or tranquilizers


* When using this product
: [[excitability]] may occur, especially in children
: may cause [[drowsiness]]
: [[alcohol]], [[sedatives]] and [[tranquilizers]] may increase drowsiness effect
* Use caution when driving a motor vehicle or operating machinery.
* If pregnant or breast-feeding, ask a health professional before use.


=====Special Senses=====
* Keep out of reach of children.


 
* In case of accidental overdose, seek professional help or contact a Poison Control Center immediately.
 
|clinicalTrials=* [[excitability]]
 
* [[drowsiness]]
=====Urogenital=====
 
 
 
 
=====Miscellaneous=====
 
 
 
<!--Postmarketing Experience-->
|postmarketing=There is limited information regarding <i>Postmarketing Experience</i> of {{PAGENAME}} in the drug label.
|postmarketing=There is limited information regarding <i>Postmarketing Experience</i> of {{PAGENAME}} in the drug label.
=====Body as a Whole=====
=====Cardiovascular=====
=====Digestive=====
=====Endocrine=====
=====Hematologic and Lymphatic=====
=====Metabolic and Nutritional=====
=====Musculoskeletal=====
=====Neurologic=====
=====Respiratory=====
=====Skin and Hypersensitivy Reactions=====


=====Special Senses=====
=====Urogenital=====
=====Miscellaneous=====






<!--Drug Interactions-->
<!--Drug Interactions-->
|drugInteractions=* Drug
|drugInteractions=*  
:* Description


<!--Use in Specific Populations-->
<!--Use in Specific Populations-->
|useInPregnancyFDA=* '''Pregnancy Category'''
|useInPregnancyFDA=* If pregnant or breast-feeding, ask a health professional before use.
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''


There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.
|useInLaborDelivery=There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
|useInLaborDelivery=There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
|useInNursing=There is no FDA guidance on the use of {{PAGENAME}} with respect to nursing mothers.
|useInNursing=* If pregnant or breast-feeding, ask a health professional before use.
|useInPed=There is no FDA guidance on the use of {{PAGENAME}} with respect to pediatric patients.
|useInPed=There is no FDA guidance on the use of {{PAGENAME}} with respect to pediatric patients.
|useInGeri=There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
|useInGeri=There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
Line 266: Line 97:
<!--Administration and Monitoring-->
<!--Administration and Monitoring-->
|administration=* Oral
|administration=* Oral
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.


* Intravenous
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.


* Description


<!--IV Compatibility-->
<!--IV Compatibility-->
Line 276: Line 105:


<!--Overdosage-->
<!--Overdosage-->
|overdose====Acute Overdose===
|overdose=There is limited information regarding <i>Overdose</i> of {{PAGENAME}} in the drug label.
 
<!--Pharmacology-->


====Signs and Symptoms====
<!--Drug box 2-->
|drugBox={{Drugbox2
| verifiedrevid = 437187307
| IUPAC_name = 1-[(4-chlorophenyl)(phenyl)methyl]-4-methylpiperazine
| image = Chlorcyclizine Wiki Str.png


* Description
<!--Clinical data-->
| tradename = 
| Drugs.com = {{drugs.com|international|chlorcyclizine}}
| MedlinePlus = a682619
| pregnancy_category = 
| legal_status = Rx-only
| routes_of_administration = Oral


====Management====
<!--Pharmacokinetic data-->
| bioavailability =
| metabolism =
| elimination_half-life =
| excretion =


* Description
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 82-93-9
| ATC_prefix = R06
| ATC_suffix = AE04
| PubChem = 2710
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2609
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = M26C4IP44P
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 22150


===Chronic Overdose===
<!--Chemical data-->
| C=18 | H=21 | Cl=1 | N=2
| molecular_weight = 300.826 g/mol
| smiles = Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)C
| InChI = 1/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3
| InChIKey = WFNAKBGANONZEQ-UHFFFAOYAF
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = WFNAKBGANONZEQ-UHFFFAOYSA-N
}}


There is limited information regarding <i>Chronic Overdose</i> of {{PAGENAME}} in the drug label.


<!--Pharmacology-->


<!--Drug box 2-->
<!--Mechanism of Action-->
|drugBox=<!--Mechanism of Action-->
|mechAction=  
|mechAction=*


<!--Structure-->
<!--Structure-->
|structure=*  
|structure======ACTIVE INGREDIENTS (IN EACH IMMEDIATE-RELEASE TABLET)=====
* Chlorcyclizine HCl 25 mg
 
=====INACTIVE INGREDIENTS=====
* Lake Blend Green, Magnesium Stearate, Microcrystalline Cellulose, Sodium Starch Glycolate
 


: [[File:{{PAGENAME}}01.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]


<!--Pharmacodynamics-->
<!--Pharmacodynamics-->
Line 314: Line 181:


<!--How Supplied-->
<!--How Supplied-->
|howSupplied=*
|howSupplied=
|packLabel=<!--Patient Counseling Information-->
|packLabel=====PRINCIPAL DISPLAY PANEL - 30 TABLET CARTON====
|fdaPatientInfo=There is limited information regarding <i>Patient Counseling Information</i> of {{PAGENAME}} in the drug label.
NDC 58407-025-30
 
AHIST™


<!--Precautions with Alcohol-->
Antihistamine
 
Each tablet contains:
 
Chlorcyclizine HCl 25 mg
 
MAGNA
Pharmaceuticals, Inc.
Louisville, KY 40299
 
30 Tablets
 
: [[File:Chlorcyclizine PDP.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
 
====Ingredients and Appearance====
 
: [[File:Chlorcyclizine Ing and App.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
 
<!--Patient Counseling Information-->
|fdaPatientInfo=====QUESTIONS OR COMMENTS?====
Call 1-888-206-5525
 
www.magnaweb.com
|alcohol=* Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
|alcohol=* Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.


<!--Brand Names-->
<!--Brand Names-->
|brandNames=* ®<ref>{{Cite web | title = | url = }}</ref>
|brandNames=* AHIST®<ref>{{Cite web | title = Chlorcyclizine hydrochloride | url =http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d50b5154-20a3-4c5b-ad7b-08c081340b12 }}</ref>


<!--Look-Alike Drug Names-->
<!--Look-Alike Drug Names-->
|lookAlike=* A® — B®<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher =  | date =  }}</ref>
<!--Drug Shortage Status-->
|drugShortage=
|drugShortage=
}}
{{PillImage
|fileName=No image.jpg
}}
{{LabelImage
|fileName={{PAGENAME}}11.png
}}
{{LabelImage
|fileName={{PAGENAME}}11.png
}}
}}
<!--Pill Image-->
<!--Pill Image-->

Latest revision as of 14:39, 6 March 2015

Chlorcyclizine
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rabin Bista, M.B.B.S. [2]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.
NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Overview

Chlorcyclizine is a antihistamine that is FDA approved for the treatment of hay fever or other upper respiratory allergies. Common adverse reactions include excitability, drowsiness.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

Directions

  • Do not exceed recommended dosage.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Chlorcyclizine in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Chlorcyclizine in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Directions

  • Do not exceed recommended dosage.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Chlorcyclizine in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Chlorcyclizine in pediatric patients.

Contraindications

There is limited information regarding Chlorcyclizine Contraindications in the drug label.

Warnings

  • Do not exceed recommended dosage.
  • Do not take this product unless directed by a doctor if you have
a breathing problem such as emphysema or chronic bronchitis
glaucoma
difficulty in urination due to enlargement of the prostate gland
  • Ask a doctor before use if you are taking sedatives or tranquilizers
  • When using this product
excitability may occur, especially in children
may cause drowsiness
alcohol, sedatives and tranquilizers may increase drowsiness effect
  • Use caution when driving a motor vehicle or operating machinery.
  • If pregnant or breast-feeding, ask a health professional before use.
  • Keep out of reach of children.
  • In case of accidental overdose, seek professional help or contact a Poison Control Center immediately.

Adverse Reactions

Clinical Trials Experience

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Chlorcyclizine in the drug label.

Drug Interactions

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • If pregnant or breast-feeding, ask a health professional before use.


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Chlorcyclizine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Chlorcyclizine during labor and delivery.

Nursing Mothers

  • If pregnant or breast-feeding, ask a health professional before use.

Pediatric Use

There is no FDA guidance on the use of Chlorcyclizine with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Chlorcyclizine with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Chlorcyclizine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Chlorcyclizine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Chlorcyclizine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Chlorcyclizine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Chlorcyclizine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Chlorcyclizine in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral

Monitoring

There is limited information regarding Monitoring of Chlorcyclizine in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Chlorcyclizine in the drug label.

Overdosage

There is limited information regarding Overdose of Chlorcyclizine in the drug label.

Pharmacology

Template:Px
Chlorcyclizine
Systematic (IUPAC) name
1-[(4-chlorophenyl)(phenyl)methyl]-4-methylpiperazine
Identifiers
CAS number 82-93-9
ATC code R06AE04
PubChem 2710
Chemical data
Formula Template:OrganicBox atomTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox 
Mol. mass 300.826 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat.

?

Legal status

Template:Unicode Prescription only

Routes Oral

Mechanism of Action

There is limited information regarding Chlorcyclizine Mechanism of Action in the drug label.

Structure

ACTIVE INGREDIENTS (IN EACH IMMEDIATE-RELEASE TABLET)
  • Chlorcyclizine HCl 25 mg
INACTIVE INGREDIENTS
  • Lake Blend Green, Magnesium Stearate, Microcrystalline Cellulose, Sodium Starch Glycolate

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Chlorcyclizine in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Chlorcyclizine in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Chlorcyclizine in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Chlorcyclizine in the drug label.

How Supplied

There is limited information regarding Chlorcyclizine How Supplied in the drug label.

Storage

There is limited information regarding Chlorcyclizine Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Chlorcyclizine |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

PRINCIPAL DISPLAY PANEL - 30 TABLET CARTON

NDC 58407-025-30

AHIST™

Antihistamine

Each tablet contains:

Chlorcyclizine HCl 25 mg

MAGNA Pharmaceuticals, Inc. Louisville, KY 40299

30 Tablets

This image is provided by the National Library of Medicine.

Ingredients and Appearance

This image is provided by the National Library of Medicine.

{{#ask: Label Page::Chlorcyclizine |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

QUESTIONS OR COMMENTS?

Call 1-888-206-5525

www.magnaweb.com

Precautions with Alcohol

  • Alcohol-Chlorcyclizine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

There is limited information regarding Chlorcyclizine Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ "Chlorcyclizine hydrochloride".
Retrieved from "https://www.wikidoc.org/index.php?title=Chlorcyclizine&oldid=1075555"