List of chemotherapeutic agents: Difference between revisions

Latest revision as of 04:08, 22 March 2015

Template:Seealso Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]; Steven Bellm, M.D. [3]

Overview

This is a list of chemotherapeutic agents that are known to be of use in chemotherapy for cancer. A full alphabetical listing is included after the categorical listing.

The agents in this list are often combined into chemotherapy regimens for polychemotherapy (combination chemotherapy).

Chemotherapeutic Agents by Category

Alkylating agents

Nitrogen mustards

Nitrosoureas

Triazenes

Platinum coordination complexes

Antimetabolites

Folic acid analogs

Pyrimidine analogs

Purine analogs

Ribonucleotide reductase inhibitors

Hydroxyurea (Hydrea)

Natural products

Vinca alkaloids

Taxanes

Epipodophyllotoxins

Camptothecins

Antineoplastic antibiotics

Antineoplastic enzymes

Hormones and Antagonists

Adrenocortical suppressants

Aminoglutethimide (Cytadren)

Glucocorticoids

Progestins

Estrogens

Esterified estrogens (Menest)

Anti-estrogens

Aromatase inhibitors

Androgens

Anti-androgens

LHRH agonists

Triptorelin (Trelstar)

GnRH agonists

GnRH antagonists

Degarelix (Firmagon)

Biologics

Monoclonal antibodies

Anti-CD3 antibodies

Catumaxomab (Removab)

Anti-CD3 & anti-CD19 antibodies

Blinatumomab (Blincyto)

Anti-CD20 antibodies

Anti-CD30 antibodies

Brentuximab (Adcetris)

Anti-CD33 antibodies

Gemtuzumab (Mylotarg)

Anti-CD52 antibodies

Alemtuzumab (Campath)

Anti-CTLA–4 antibodies

Ipilimumab (Yervoy)

Anti-EGFR (ErbB1) antibodies

Anti-PD–1 antibodies

Anti-HER2/neu (ErbB2) antibodies

Anti-VEGF antibodies

IL-6 inhibitors

Immunotherapy

Hematopoietic Growth Factors

Erythrocyte growth factors

Erythropoietin (Procrit)

Granulocyte growth factors

Megakaryocyte growth factors

Supportive Medications

Chemotherapy protective agents

Antiemetic agents

Netupitant and palonosetron (Akynzeo)

RANK ligand inhibitors

Denosumab (Xgeva)

Calcium regulators

Miscellaneous

Mitotic inhibitors

HDAC inhibitors

Hedgehog pathway inhibitors

Vismodegib (Erivedge)

Immunomodulatory drugs (IMiDs)

Kinase inhibitors

Photosensitizing agents

Proteasome inhibitors

Radioactive agents

Radium-223 chloride (Xofigo)

Somatostatin analogs

Octreotide (Octreotide)

Differentiating agents

Orphan drugs

Chemotherapeutic Agents in Alphabetical Order

3

@@ Line 1: / Line 1: @@
 __NOTOC__
-{{SI}}
 {{Seealso|Chemotherapy regimens}}
-{{CMG}}; {{AE}} {{AV}}
+{{CMG}}; {{AE}} {{AV}}; {{Steven}}
 ==Overview==
@@ Line 16: / Line 15: @@
 * [[Chlorambucil|Chlorambucil (Leukeran)]]
 * [[Cyclophosphamide|Cyclophosphamide (Cytoxan)]]
+* [[Estramustine |Estramustine  (Emcyt)]]
 * [[Ifosfamide|Ifosfamide (Iflex)]]
 * [[Melphalan|Melphalan (Alkeran)]]
@@ Line 52: / Line 52: @@
 * [[Methotrexate|Methotrexate (Mexate, Folex)]]
 * [[Pemetrexed|Pemetrexed (Alimta)]]
+* [[Pralatrexate|Pralatrexate (Folotyn)]]
 ====== Pyrimidine analogs ======
@@ Line 57: / Line 58: @@
 * [[Capecitabine|Capecitabine (Xeloda)]]
 * [[Cytarabine|Cytarabine (Cytosar)]]
+* [[Decitabine|Decitabine (Dacogen)]]
 * [[Floxuridine|Floxuridine (FUDR)]]
 * [[Fluorouracil|Fluorouracil (Adrucil, Efudex)]]
 * [[Gemcitabine|Gemcitabine (Gemzar)]]
+* [[Raltitrexed|Raltitrexed (Tomudex)]]
 ====== Purine analogs ======
@@ Line 87: / Line 90: @@
 * [[Docetaxel|Docetaxel (Taxotere)]]
 * [[Paclitaxel|Paclitaxel (Taxol, Onxol)]]
+* [[Paclitaxel protein-bound|Paclitaxel protein-bound (Abraxane)]]
 ====== Epipodophyllotoxins ======
@@ Line 92: / Line 96: @@
 * [[Teniposide|Teniposide (Vumon)]]
-====== Camptothecins/Topoisomerase inhibitors ======
+====== Camptothecins ======
 * [[Irinotecan|Irinotecan (Camptosar)]]
 * [[Topotecan|Topotecan (Hycamtin)]]
@@ Line 99: / Line 103: @@
 * [[Bleomycin|Bleomycin (Blenoxane)]]
 * [[Dactinomycin|Dactinomycin (Cosmegen)]]
-* [[Daunorubicin|Daunorubicin (Daunoxome)]]
+* [[Daunorubicin |Daunorubicin (Cerubidine)]]
+* [[Daunorubicin liposome|Daunorubicin liposome (Daunoxome)]]
 * [[Doxorubicin|Doxorubicin (Adriamycin, Rubex)]]
 * [[Epirubicin|Epirubicin (Ellence)]]
@@ Line 105: / Line 110: @@
 * [[Mitomycin C|Mitomycin C (Mutamycin)]]
 * [[Mitoxantrone|Mitoxantrone (Novantrone)]]
+* [[Pixantrone|Pixantrone (Pixuvri)]]
+* [[Plicamycin|Plicamycin (Mithracin)]]
 * [[Valrubicin|Valrubicin (Valstar)]]
@@ Line 117: / Line 124: @@
 ====== Adrenocortical suppressants ======
+* [[Aminoglutethimide|Aminoglutethimide (Cytadren)]]
 * [[Mitotane|Mitotane (Lysodren)]]
+* [[Trilostane|Trilostane (Modrenal)]]
-====== Adrenocortico-steroids ======
+====== Glucocorticoids ======
+* [[Dexamethasone|Dexamethasone (Decadron)]]
 * [[Prednisone|Prednisone (Deltasone)]]
 ====== Progestins ======
-* [[Medroxyprogesterone|Medroxyprogesterone (Provera)]]
+* [[Medroxyprogesterone acetate|Medroxyprogesterone acetate (Provera)]]
 * [[Megestrol|Megestrol (Megace)]]
+====== Estrogens ======
+* [[Esterified estrogens|Esterified estrogens (Menest)]]
 ====== Anti-estrogens ======
+* [[Fulvestrant|Fulvestrant (Faslodex)]]
+* [[Raloxifene|Raloxifene (Evista)]]
 * [[Tamoxifen|Tamoxifen (Nolvadex)]]
 * [[Toremifene|Toremifene (Fareston)]]
 ====== Aromatase inhibitors ======
-* [[Aminoglutethimide|Aminoglutethimide (Cytadren)]]
 * [[Anastrozole|Anastrozole (Arimidex)]]
 * [[Exemestane|Exemestane (Aromasin)]]
+* [[Formestane|Formestane (Lentaron)]]
 * [[Letrozole|Letrozole (Femara)]]
 ====== Androgens ======
 * [[Fluoxymesterone|Fluoxymesterone (Halotestin)]]
+* [[Testolactone|Testolactone (Teslac)]]
 ====== Anti-androgens ======
@@ Line 164: / Line 181: @@
 ===== Monoclonal antibodies =====
+====== Anti-CD3 antibodies ======
+* [[Catumaxomab|Catumaxomab (Removab)]]
+====== Anti-CD3 & anti-CD19 antibodies ======
+* [[Blinatumomab|Blinatumomab (Blincyto)]]
 ====== Anti-CD20 antibodies ======
 * [[Rituximab|Rituximab (Rituxan)]]
-* [[Ibritumomab|Ibritumomab (Zevalin)]]
+* [[Ibritumomab tiuxetan|Ibritumomab tiuxetan (Zevalin))]]
 * [[Obinutuzumab|Obinutuzumab (Gazyva)]]
 * [[Ofatumumab|Ofatumumab (Arzerra)]]
+* [[Tositumomab|Tositumomab (Bexxar)]]
 ====== Anti-CD30 antibodies ======
@@ Line 193: / Line 217: @@
 ====== Anti-HER2/neu (ErbB2) antibodies ======
 * [[Ado-trastuzumab emtansine|Ado-trastuzumab (Kadcyla)]]
+* [[Pertuzumab|Pertuzumab (Perjeta)]]
 * [[Trastuzumab|Trastuzumab (Herceptin)]]
 ====== Anti-VEGF antibodies ======
 * [[Bevacizumab|Bevacizumab (Avastin)]]
+* [[Ramucirumab|Ramucirumab (Cyramza)]]
-===== IL-2 inhibitors =====
-* [[Aldesleukin|Aldesleukin (Proleukin)]]
-* [[Denileukin diftitox|Denileukin diftitox (Ontak)]]
 ===== IL-6 inhibitors =====
 * [[Siltuximab|Siltuximab (Sylvant)]]
+* [[Tocilizumab|Tocilizumab (Actemra)]]
 ===== Immunotherapy =====
+* [[Aldesleukin|Aldesleukin (Proleukin)]]
+* [[Denileukin diftitox|Denileukin diftitox (Ontak)]]
 * [[Interferon alfa-2b|Interferon alfa-2b (Intron A)]]
+* [[Peginterferon alfa-2a|Peginterferon alfa-2a (Pegasys)]]
+* [[Pegylated interferon alfa-2b|Peginterferon alfa-2b (Sylatron)]]
 ----
@@ Line 216: / Line 243: @@
 ===== Granulocyte growth factors =====
-* [[Filgrastim|Filgrastim (Granix)]]
+* [[Filgrastim|Filgrastim (Neupogen)]]
-* [[Sargramostim|Sargramostin (Leukine)]]
+* [[Pegfilgrastim|Pegfilgrastim (Neulasta)]]
+* [[Plerixafor|Plerixafor (Mozobil)]]
+* [[Sargramostim|Sargramostin (Leukine, Leukomax)]]
 * [[Tbo-filgrastim|Tbo-filgrastim (Granix)]]
 ===== Megakaryocyte growth factors =====
 * [[Eltrombopag|Eltrombopag (Promacta)]]
+* [[Oprelvekin|Oprelvekin (Neumega)]]
 ----
@@ Line 229: / Line 259: @@
 ===== Chemotherapy protective agents =====
 * [[Amifostine|Amifostine (Ethyol)]]
-* [[Cyanocobalamin|Cyanocobalamin]]
+* [[Cyanocobalamin|Cyanocobalamin (Cobal)]]
 * [[Dexrazoxane|Dexrazoxane (Zinecard)]]
-* [[Folinic acid|Folinic acid (Leucovorin)]]
+* [[Folinic acid|Folinic acid (Leucovorin Calcium)]]
 * [[Glucarpidase|Glucarpidase (Voraxaze)]]
 * [[Levoleucovorin|Levoleucovorin (Fusilev)]]
 * [[Mesna|Mesna (Mesnex)]]
+* [[Rasburicase|Rasburicase (Elitek)]]
 ===== Antiemetic agents =====
@@ Line 241: / Line 272: @@
 ===== RANK ligand inhibitors =====
 * [[Denosumab|Denosumab (Xgeva)]]
+===== Calcium regulators =====
+* [[Gallium nitrate|Gallium nitrate (Ganite)]]
+* [[Pamidronate|Pamidronate (Aredia)]]
+* [[Zoledronic Acid|Zoledronic Acid (Zometa)]]
 ----
@@ Line 248: / Line 284: @@
 ===== Mitotic inhibitors =====
 * [[Amsacrine|Amsacrine (Amsidine)]]
+* [[Cabazitaxel|Cabazitaxel (Jevtana)]]
 * [[Eribulin|Eribulin (Halaven)]]
 * [[Ixabepilone|Ixabepilone (Ixempra)]]
-===== Bisphosphonates =====
-* [[Zoledronic Acid|Zoledronic Acid (Zometa)]]
 ===== HDAC inhibitors =====
@@ Line 263: / Line 297: @@
 ===== Immunomodulatory drugs (IMiDs) =====
-* [[Everolimus|Everolimus (Afinitor)]]
 * [[Lenalidomide|Lenalidomide (Revlimid)]]
 * [[Pomalidomide|Pomalidomide (Pomalyst)]]
+* [[Sipuleucel-T|Sipuleucel-T (Provenge)]]
+* [[Thalidomide|Thalidomide (Thalomid)]]
 ===== Kinase inhibitors =====
 * [[Afatinib|Afatinib (Gliotrif)]]
 * [[Axitinib|Axitinib (Inlyta)]]
+* [[Bosutinib|Bosutinib (Bosulif)]]
 * [[Cabozantinib|Cabozantinib (Cometriq)]]
+* [[Ceritinib|Ceritinib (Zykadia)]]
 * [[Crizotinib|Crizotinib (Xalkori)]]
+* [[Dabrafenib|Dabrafenib (Tafinlar)]]
 * [[Dasatinib|Dasatinib (Sprycel)]]
 * [[Erlotinib|Erlotinib (Tarceva)]]
+* [[Everolimus|Everolimus (Afinitor)]]
 * [[Gefitinib|Gefitinib (Iressa)]]
 * [[Ibrutinib|Ibrutinib (Imbruvica)]]
 * [[Idelalisib|Idelalisib (Zydelig)]]
+* [[Imatinib|Imatinib (Gleevec)]]
 * [[Lapatinib|Lapatinib (Tykerb)]]
+* [[Lenvatinib|Lenvatinib (Lenvima)]]
 * [[Nilotinib|Nilotinib (Tasigna)]]
 * [[Palbociclib|Palbociclib (Ibrance)]]
+* [[Regorafenib|Regorafenib (Stivarga)]]
+* [[Ruxolitinib|Ruxolitinib (Jakafi)]]
 * [[Sorafenib|Sorafenib (Nexavar)]]
 * [[Sunitinib|Sunitinib (Sutent)]]
+* [[Temsirolimus|Temsirolimus (Torisel)]]
+* [[Trametinib|Trametinib (Mekinist)]]
+* [[Vandetanib|Vandetanib (Caprelsa)]]
 * [[Vemurafenib|Vemurafenib (Zelboraf)]]
 * [[Ziv-aflibercept|Ziv-aflibercept (Zaltrap)]]
-===== mTOR Inhibitors =====
-* [[Temsirolimus|Temsirolimus (Torisel)]]
-* [[Everolimus|Everolimus (Afinitor)]]
 ===== Photosensitizing agents =====
 * [[Aminolevulinic acid |Aminolevulinic acid (Levulan)]]
+* [[Porfimer|Porfimer (Photofrin)]]
 ===== Proteasome inhibitors =====
@@ Line 302: / Line 345: @@
 * [[Octreotide|Octreotide (Octreotide)]]
-===== Retinoid =====
+===== Differentiating agents =====
+* [[Arsenic trioxide|Arsenic trioxide (Trisenox)]]
 * [[Bexarotene|Bexarotene (Targretin)]]
+* [[Tretinoin|Tretinoin (Vesanoid)]]
+===== Orphan drugs =====
+* [[Olaparib|Olaparib (Lynparza)]]
-===== VEGF receptor-2 antagonists =====
+* [[Omacetaxine|Omacetaxine (Synribo)]]
-* [[Ramucirumab|Ramucirumab (Cyramza)]]
+* [[Ranpirnase|Ranpirnase (Onconase)]]
+* [[Trabectedin|Trabectedin (Yondelis)]]
 == Chemotherapeutic Agents in Alphabetical Order ==
-{{Columns-list|2|
+{{Columns-list|3|
 * [[Abarelix|Abarelix (Plenaxis)]]
 * [[Abiraterone|Abiraterone acetate (Zytiga)]]
@@ Line 494: / Line 540: @@
 * [[Trastuzumab|Trastuzumab (Herceptin)]]
 * [[Tretinoin|Tretinoin (Vesanoid)]]
-* [[Trilostane|Trilostane (Vetoryl)]]
+* [[Trilostane|Trilostane (Modrenal)]]
 * [[Triptorelin pamoate|Triptorelin pamoate (Trelstar)]]
 * [[Valrubicin|Valrubicin (Valstar)]]