FOLFOX regimen

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2];

Synonyms and keywords:CF/5-FU/L-OHP; Fluorouracil/Leucovorin Calcium/Oxaliplatin; FOLFOX; FOLFOX Regimen; FOLFOX regimen

Overview

FOLFOX regimen refers to a chemotherapy combination used to treat colorectal cancer that is advanced or has come back. It is also being studied in the treatment of other types of cancer. It includes the drugs leucovorin calcium (folinic acid), fluorouracil, and oxaliplatin. FOLFOX-4, FOLFOX-6, modified FOLFOX-6 (mFOLFOX-6), and FOLFOX-7 are different in the doses of the three drugs and the ways they are given.

Regimen

FOLLeucovorin Calcium (folinic acid)

FFluorouracil

OXOxaliplatin

Indications

• Colorectal cancer