Terodiline: Difference between revisions
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[[File:Terodiline.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]</div> | [[File:Terodiline.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]</div> | ||
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It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity. | It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity. | ||
However, it also blocks IKr (Kv11.1) channels (see [[hERG]] gene) so can pose a risk for [[torsades de pointes]]. This cardiotoxicity is concentration dependent. | However, it also blocks IKr (Kv11.1) channels (see [[hERG]] gene) so can pose a risk for [[torsades de pointes]]. This cardiotoxicity is concentration dependent. | ||
==References== | ==References== | ||
Latest revision as of 17:14, 20 August 2015
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WikiDoc Resources for Terodiline |
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Articles |
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Most recent articles on Terodiline |
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Ongoing Trials on Terodiline at Clinical Trials.gov Clinical Trials on Terodiline at Google
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US National Guidelines Clearinghouse on Terodiline
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Patient resources on Terodiline Discussion groups on Terodiline Patient Handouts on Terodiline Directions to Hospitals Treating Terodiline Risk calculators and risk factors for Terodiline
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Causes & Risk Factors for Terodiline |
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Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Terodiline is a drug used in urology as an antispasmodic.
It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity.
However, it also blocks IKr (Kv11.1) channels (see hERG gene) so can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent.