Niflumic acid

{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 457481224 | IUPAC_name = 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid | image = Niflumic acid.png

| tradename = | Drugs.com = International Drug Names | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration =

| bioavailability = | protein_bound = | metabolism = | elimination_half-life = 2.5 hr | excretion =

| CASNo_Ref =  ^N | CAS_number_Ref =  ^Y | CAS_number = 4394-00-7 | ATC_prefix = M01 | ATC_suffix = AX02 | ATC_supplemental = M02AA17 (WHO) | IUPHAR_ligand = 2439 | DrugBank_Ref =  ^Y | DrugBank = | ChEMBL_Ref =  ^N | ChEMBL = 63323 | UNII_Ref =  ^N | UNII = 4U5MP5IUD8 | KEGG_Ref =  ^Y | KEGG = D08275 | PubChem = 4488 | ChemSpiderID_Ref =  ^N | ChemSpiderID = 4333 | smiles = C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F | InChI = 1/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20) | InChIKey = JZFPYUNJRRFVQU-UHFFFAOYAR | StdInChI_Ref =  ^N | StdInChI = 1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20) | StdInChIKey_Ref =  ^N | StdInChIKey = JZFPYUNJRRFVQU-UHFFFAOYSA-N

| C=13 | H=9 | F=3 | N=2 | O=2 | molecular_weight = 282.21797 g/mol }}

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor of cyclooxygenase-2. In experimental biology, it has been employed to inhibit chloride channels. It has also been reported to act on GABA-A and NMDA channels and to block T-type calcium channels.