Clopenthixol: Difference between revisions
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| IUPAC_name = ''(E,Z)''-2-[4-[3-(2-chlorothioxanthen-9-ylidene) propyl]piperazin-1-yl]ethanol | | IUPAC_name = ''(E,Z)''-2-[4-[3-(2-chlorothioxanthen-9-ylidene) propyl]piperazin-1-yl]ethanol | ||
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==Overview== | |||
'''Clopenthixol''' ('''Sordinol'''), also known as '''clopentixol''', is a [[typical antipsychotic]] [[drug]] of the [[thioxanthene]] class. It was introduced by [[Lundbeck]] in 1961.<ref name="isbn0-471-89980-1">{{cite book | author = Sneader, Walter | title = Drug discovery: a history | publisher = Wiley | location = New York | year = 2005 | page = 410 | isbn = 0-471-89980-1 | oclc = | doi = | url = http://books.google.com/?id=Cb6BOkj9fK4C&lpg=PA410&pg=PA410#v=onepage}}</ref> | '''Clopenthixol''' ('''Sordinol'''), also known as '''clopentixol''', is a [[typical antipsychotic]] [[drug]] of the [[thioxanthene]] class. It was introduced by [[Lundbeck]] in 1961.<ref name="isbn0-471-89980-1">{{cite book | author = Sneader, Walter | title = Drug discovery: a history | publisher = Wiley | location = New York | year = 2005 | page = 410 | isbn = 0-471-89980-1 | oclc = | doi = | url = http://books.google.com/?id=Cb6BOkj9fK4C&lpg=PA410&pg=PA410#v=onepage}}</ref> | ||
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== References == | == References == | ||
{{Reflist}} | {{Reflist|2}} | ||
== External links == | == External links == | ||
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{{Antipsychotics}} | {{Antipsychotics}} | ||
[[Category:Piperazines]] | [[Category:Piperazines]] | ||
[[Category:Organochlorides]] | [[Category:Organochlorides]] | ||
[[Category:Alcohols]] | [[Category:Alcohols]] | ||
[[Category: | [[Category:Drug]] | ||
Latest revision as of 19:18, 18 August 2015
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| Routes of administration | Oral |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
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| Formula | C22H25ClN2OS |
| Molar mass | 400.965 g/mol |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Clopenthixol (Sordinol), also known as clopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced by Lundbeck in 1961.[1]
Clopenthixol is a racemic mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, was later introduced by Lundbeck in 1962,[2] and has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.[3]
Clopenthixol is not approved for use in the United States.
See also
References
- ↑ Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1.
- ↑ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 516. ISBN 3-527-31058-4.
- ↑ Gravem A, Engstrand E, Guleng RJ (November 1978). "Cis(Z)-clopenthixol and clopenthixol (Sordinol) in chronic psychotic patients. A double-blind clinical investigation". Acta Psychiatr Scand. 58 (5): 384–8. doi:10.1111/j.1600-0447.1978.tb03570.x. PMID 362830.
External links
- Clopenthixol at the US National Library of Medicine Medical Subject Headings (MeSH)
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- Piperazines
- Organochlorides
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