Stibophen: Difference between revisions

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Stibophen
Clinical data
ATC code	P02BX03 (WHO) ;
Identifiers
	IUPAC name Pentasodium 2-(2-oxido-3,5-disulfonatophenoxy)-1,3,2-benzodioxastibole-5,7-disulfonate;
CAS Number	23940-36-5;
PubChem CID	16683091;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C12H4Na5O16S4Sb
Molar mass	769.12 g/mol
3D model (JSmol)	Interactive image;
	SMILES C1=C(C=C2C(=C1S(=O)(=O)[O-])O[Sb](O2)OC3=CC(=CC(=C3[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+];
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Latest revision as of 17:10, 20 August 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Stibophen is an anthelmintic classified as antimony compound and used as treatment of schistosomiasis^[1] by intramuscular injection.

Stibophen inhibits the enzyme phosphofructokinase, which the worms need for glycolysis,^[2] at least partly by binding to the sulfhydryl (–SH) group of the enzyme.^[3] Inhibiting glycolysis paralyzes the worms, which lose their hold on the wall of mesenteric veins and undergo hepatic shift, die, and are phagocytosed by liver cells.^{[citation needed]}

↑ PMID 13268811 (PMID 13268811)
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↑ PMID 13446367 (PMID 13446367)
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↑ PMID 8898332 (PMID 8898332)
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@@ Line 38: / Line 38: @@
 | smiles = C1=C(C=C2C(=C1S(=O)(=O)[O-])O[Sb](O2)OC3=CC(=CC(=C3[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+]
 }}
+                     __NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
 '''Stibophen''' is an [[anthelmintic]] classified as antimony compound and used as treatment of [[schistosomiasis]]<ref>{{cite pmid|13268811}}</ref> by [[intramuscular injection]].
@@ Line 50: / Line 54: @@
 [[Category:Antiparasitic agents]]
-[[Category:Sulfonates]]
+[[Category:Drug]]
-[[Category:Antimony compounds]]
-{{antiinfective-drug-stub}}

Clinical data

ATC code	P02BX03 (WHO)
Identifiers
IUPAC name Pentasodium 2-(2-oxido-3,5-disulfonatophenoxy)-1,3,2-benzodioxastibole-5,7-disulfonate
CAS Number	23940-36-5
PubChem CID	16683091
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₂H₄Na₅O₁₆S₄Sb
Molar mass	769.12 g/mol
3D model (JSmol)	Interactive image
SMILES C1=C(C=C2C(=C1S(=O)(=O)[O-])O[Sb](O2)OC3=CC(=CC(=C3[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+]
(verify)