Sandbox Organ-Based Infections: Difference between revisions
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<div style="float: right; font-size: 75%;">__TOC__</div> | <div style="float: right; font-size: 75%;">__TOC__</div>__NOEDITSECTION__ | ||
==Musculoskeletal== | ==Musculoskeletal== | ||
| Line 37: | Line 37: | ||
* '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Linezolid]]''' 600 mg po/IV bid | * '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Linezolid]]''' 600 mg po/IV bid | ||
</li> | </li> | ||
{{Rx| | {{Rx|MSSA}} | ||
* '''[[Nafcillin]]''' 2 gm IV q4h {{or}} '''[[Oxacillin]]''' 2 gm IV q4h {{or}} '''[[Cefazolin]]''' 2 gm IV q8h | * '''[[Nafcillin]]''' 2 gm IV q4h {{or}} '''[[Oxacillin]]''' 2 gm IV q4h {{or}} '''[[Cefazolin]]''' 2 gm IV q8h | ||
</li> | </li> | ||
{{Rx| | {{Rx|MRSA}} | ||
* '''[[Vancomycin]]''' 15-20 mg/kg IV q8-12h targeting trough concentrations of 15-20 mg/L | * '''[[Vancomycin]]''' 15-20 mg/kg IV q8-12h targeting trough concentrations of 15-20 mg/L | ||
</li> | </li> | ||
{{Rx| | {{Rx|Staphylococcus aureus (MRSA/MSSA)}} | ||
* '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po once daily if susceptible {{and}} | * '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po once daily if susceptible {{and}} | ||
* '''[[Rifampin]]''' 300-450 mg po bid {{or}} '''[[Rifampin]]''' 600 mg po once daily if susceptible | * '''[[Rifampin]]''' 300-450 mg po bid {{or}} '''[[Rifampin]]''' 600 mg po once daily if susceptible | ||
| Line 49: | Line 49: | ||
====Diabetic foot==== | ====Diabetic foot==== | ||
{{Rx|Chronic | {{Rx|Chronic infection}} | ||
* '''[[Levofloxacin]]''' 750 mg IV/PO q24h {{or}} '''[[Cefoxitin]]''' 1 g IV q4h (or 2 g IV q6–8h) {{or}} '''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ampicillin-Sulbactam]]''' 1.5–3 g IV/IM q6h {{or}} '''[[Moxifloxacin]]''' 400 mg IV/PO q24h {{or}} '''[[Ertapenem]]''' 1 g IV/IM q24h {{or}} '''[[Tigecycline]]''' 100 mg IV, then 50 mg IV q12h {{or}} '''[[Imipenem-Cilastatin]]''' 0.5–1 g IV q6–8h | |||
</li> | |||
{{Rx|Recent antibiotic use}} | |||
* '''[[Levofloxacin]]''' 750 mg IV/PO q24h {{or}} '''[[Cefoxitin]]''' 1 g IV q4h (or 2 g IV q6–8h) {{or}} '''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ampicillin-Sulbactam]]''' 1.5–3 g IV/IM q6h {{or}} '''[[Moxifloxacin]]''' 400 mg IV/PO q24h {{or}} '''[[Ertapenem]]''' 1 g IV/IM q24h {{or}} '''[[Tigecycline]]''' 100 mg IV, then 50 mg IV q12h {{or}} '''[[Imipenem-Cilastatin]]''' 0.5–1 g IV q6–8h | * '''[[Levofloxacin]]''' 750 mg IV/PO q24h {{or}} '''[[Cefoxitin]]''' 1 g IV q4h (or 2 g IV q6–8h) {{or}} '''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ampicillin-Sulbactam]]''' 1.5–3 g IV/IM q6h {{or}} '''[[Moxifloxacin]]''' 400 mg IV/PO q24h {{or}} '''[[Ertapenem]]''' 1 g IV/IM q24h {{or}} '''[[Tigecycline]]''' 100 mg IV, then 50 mg IV q12h {{or}} '''[[Imipenem-Cilastatin]]''' 0.5–1 g IV q6–8h | ||
</li> | </li> | ||
| Line 73: | Line 76: | ||
====Foot puncture wound==== | ====Foot puncture wound==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* ''' | * '''Cleanse wound''' {{and}} | ||
* ''' | * '''Tetanus booster''' if due {{and}} | ||
* '''X-ray''' to exclude presence of radio-opaque foreign body | |||
</li> | </li> | ||
====Hematogenous==== | ====Hematogenous==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[ | * MRSA likely – '''[[Vancomycin]]''' 15–20 mg/kg IV q8–12h {{and2}} ('''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q12h) | ||
* '''[[ | * MRSA unlikely – ('''[[Nafcillin]]''' {{or}} '''[[Oxacillin]]''') {{and2}} ('''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ceftazidime]]''' 2 gm IV q8h {{or}} '''[[Cefepime]]''' 2 gm IV q12h) | ||
</li> | </li> | ||
{{Rx|Alternative Regimen}} | {{Rx|Alternative Regimen}} | ||
* '''[[ | * '''[[Linezolid]]''' 600 mg po/IV bid {{or}} '''[[Daptomycin]]''' 4 mg/kg IV q24h to replace vancomycin | ||
* '''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg IV/PO q24h {{or}} '''[[Aztreonam]]''' 2 g IV q6–8h to replace a third-generation cephalosporin | |||
</li> | </li> | ||
====Hemoglobinopathy==== | ====Hemoglobinopathy==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[ | * '''[[Ciprofloxacin]]''' 400 mg IV q12h {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h | ||
</li> | </li> | ||
{{Rx|Alternative Regimen}} | {{Rx|Alternative Regimen}} | ||
* '''[[ | * '''[[Ciprofloxacin]]''' 750 mg po bid for 6 weeks {{or}} '''[[Levofloxacin]]''' 750 mg po q24h for 6 weeks | ||
</li> | </li> | ||
====Prosthetic joint infection==== | ====Prosthetic joint infection==== | ||
{{Rx| | {{Rx|MSSA/MSSE}} | ||
* '''[[ | * ('''[[Nafcillin]]''' 2 gm IV q4h {{or}} '''[[Oxacillin]]''' 2 gm IV q4h IV) {{plus}} '''[[Rifampin]]''' 300 mg po bid {{or2}} | ||
* '''[[ | * '''[[Cefazolin]]''' 2 gm IV q8h {{plus}} '''[[Rifampin]]''' 300 mg po bid for 2-6 weeks followed by ('''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h) {{plus}} '''[[Rifampin]]''' 300 mg po bid for 3-6 months | ||
</li> | |||
{{Rx|MRSA/MRSE}} | |||
* '''[[Vancomycin]]''' 15-20 mg/kg IV q8-12h {{plus}} '''[[Rifampin]]''' 300 mg po bid for 2-6 weeks followed by ('''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h) {{plus}} '''[[Rifampin]]''' 300 mg po bid for 3-6 months | |||
</li> | |||
{{Rx|Streptococcus}} | |||
* '''[[Penicillin G]]''' 20 million units IV continuous infusion q24h or in 6 divided doses {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h x 4-6 weeks | |||
</li> | |||
{{Rx|Enterococcus}} | |||
* Penicillin-susceptible – '''[[Ampicillin]]''' 12 gm IV {{or}} '''[[Penicillin G]]''' 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks | |||
* Penicillin-resistant – '''[[Vancomycin]]''' 15 mg/kg IV q12h x 4-6 week | |||
</li> | |||
{{Rx|Propionibacterium acnes}} | |||
* '''[[Penicillin G]]''' 20 million units IV continuous infusion or in 6 divided doses {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h x 4-6 weeks | |||
</li> | |||
{{Rx|Gram-negative enteric bacilli}} | |||
* '''[[Ertapenem]]''' 1 gm q24h IV {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h {{or}} '''[[Cefepime]]''' 2 gm IV q12h for 4-6 weeks | |||
</li> | </li> | ||
{{Rx| | {{Rx|Pseudomonas aeruginosa}} | ||
* '''[[ | * '''[[Cefepime]]''' 2 gm IV q12h {{or}} '''[[Meropenem]]''' 1 gm IV q8h for 4-6 weeks {{and}} | ||
* '''[[ | * '''[[Tobramycin]]''' 5.1 mg/kg once daily IV for 4-6 weeks | ||
</li> | </li> | ||
====Spinal implant==== | ====Spinal implant==== | ||
{{Rx| | {{Rx|MSSA/MSSE}} | ||
* '''[[ | * ('''[[Nafcillin]]''' 2 gm IV q4h {{or}} '''[[Oxacillin]]''' 2 gm IV q4h IV) {{plus}} '''[[Rifampin]]''' 300 mg po bid {{or2}} | ||
* '''[[ | * '''[[Cefazolin]]''' 2 gm IV q8h {{plus}} '''[[Rifampin]]''' 300 mg po bid for 2-6 weeks followed by ('''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h) {{plus}} '''[[Rifampin]]''' 300 mg po bid for 3-6 months | ||
</li> | </li> | ||
{{Rx| | {{Rx|MRSA/MRSE}} | ||
* '''[[ | * '''[[Vancomycin]]''' 15-20 mg/kg IV q8-12h {{plus}} '''[[Rifampin]]''' 300 mg po bid for 2-6 weeks followed by ('''[[Ciprofloxacin]]''' 750 mg po bid {{or}} '''[[Levofloxacin]]''' 750 mg po q24h) {{plus}} '''[[Rifampin]]''' 300 mg po bid for 3-6 months | ||
</li> | </li> | ||
{{Rx|Streptococcus}} | |||
* '''[[Penicillin G]]''' 20 million units IV continuous infusion q24h or in 6 divided doses {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h x 4-6 weeks | |||
{{Rx| | </li> | ||
* '''[[ | {{Rx|Enterococcus}} | ||
* '''[[ | * Penicillin-susceptible – '''[[Ampicillin]]''' 12 gm IV {{or}} '''[[Penicillin G]]''' 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks | ||
* Penicillin-resistant – '''[[Vancomycin]]''' 15 mg/kg IV q12h x 4-6 week | |||
</li> | |||
{{Rx|Propionibacterium acnes}} | |||
* '''[[Penicillin G]]''' 20 million units IV continuous infusion or in 6 divided doses {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h x 4-6 weeks | |||
</li> | |||
{{Rx|Gram-negative enteric bacilli}} | |||
* '''[[Ertapenem]]''' 1 gm q24h IV {{or}} '''[[Ceftriaxone]]''' 2 gm IV q24h {{or}} '''[[Cefepime]]''' 2 gm IV q12h for 4-6 weeks | |||
</li> | </li> | ||
{{Rx| | {{Rx|Pseudomonas aeruginosa}} | ||
* '''[[ | * '''[[Cefepime]]''' 2 gm IV q12h {{or}} '''[[Meropenem]]''' 1 gm IV q8h for 4-6 weeks {{and}} | ||
* '''[[ | * '''[[Tobramycin]]''' 5.1 mg/kg once daily IV for 4-6 weeks | ||
</li> | </li> | ||
====Sternal==== | ====Sternal==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[ | * '''[[Vancomycin]]''' 15-30 mg/kg IV q 8-12h targeting trough of 15-20 μg/mL {{or}} '''[[Nafcillin]]''' 2 gm IV q4h | ||
</li> | </li> | ||
{{Rx|Alternative Regimen}} | {{Rx|Alternative Regimen}} | ||
* '''[[ | * '''[[Linezolid]]''' 600 mg IV/po bid | ||
</li> | </li> | ||
| Line 1,048: | Line 1,066: | ||
==Cardiovascular== | ==Cardiovascular== | ||
===Endocarditis=== | ===Endocarditis=== | ||
| Line 1,251: | Line 1,268: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
===Pericarditis=== | |||
====Bacterial pericarditis==== | ====Bacterial pericarditis==== | ||
| Line 1,261: | Line 1,280: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
====Histoplasmosis==== | ====Histoplasmosis==== | ||
| Line 2,913: | Line 2,929: | ||
===Pneumonia=== | ===Pneumonia=== | ||
====Community-acquired pneumonia, | ====Community-acquired pneumonia, Pediatric, age < 1 month==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 2,923: | Line 2,939: | ||
</li> | </li> | ||
====Community-acquired pneumonia, | ====Community-acquired pneumonia, Pediatric, age 1–3 months==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 2,933: | Line 2,949: | ||
</li> | </li> | ||
====Community-acquired pneumonia, | ====Community-acquired pneumonia, Pediatric, age > 3 months==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,355: | Line 3,371: | ||
</li> | </li> | ||
=== | ===Sinusitis=== | ||
==== | ====Sinusitis, Acute==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,367: | Line 3,383: | ||
</li> | </li> | ||
==== | ====Sinusitis, Treatment failure==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,377: | Line 3,393: | ||
</li> | </li> | ||
==== | ====Sinusitis, Chronic==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,387: | Line 3,403: | ||
</li> | </li> | ||
==== | ====Sinusitis, Post-intubation==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,396: | Line 3,412: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
===Stomatitis=== | |||
=== | ====Aphthous stomatitis==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,409: | Line 3,425: | ||
</li> | </li> | ||
==== | ====Buccal cellulitis==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,419: | Line 3,435: | ||
</li> | </li> | ||
==== | ====Gingivostomatitis==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,429: | Line 3,445: | ||
</li> | </li> | ||
==== | ====Herpetic stomatitis==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,438: | Line 3,454: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
==== | ====Ludwig's angina==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,451: | Line 3,465: | ||
</li> | </li> | ||
==== | ====Submandibular space infection==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,461: | Line 3,475: | ||
</li> | </li> | ||
==== | ====Ulcerative gingivitis==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,471: | Line 3,485: | ||
</li> | </li> | ||
==== | ====Vincent's angina==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,480: | Line 3,494: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
==== | ==Head and neck== | ||
===Oropharyngeal anthrax=== | |||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,490: | Line 3,506: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
=== | ===Buccal cellulitis=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,501: | Line 3,517: | ||
</li> | </li> | ||
=== | ===Cervico-facial actinomycosis=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,511: | Line 3,527: | ||
</li> | </li> | ||
=== | ===Odontogenic infection=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,520: | Line 3,536: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
===Oropharyngeal candidiasis=== | |||
===Oropharyngeal | |||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,533: | Line 3,546: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
=== | ===Facial cellulitis=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,544: | Line 3,557: | ||
</li> | </li> | ||
==== | ===Mastoiditis=== | ||
====Mastoiditis, Acute==== | |||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,554: | Line 3,569: | ||
</li> | </li> | ||
==== | ====Mastoiditis, Chronic==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,564: | Line 3,579: | ||
</li> | </li> | ||
=== | ===Orbital cellulitis=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,573: | Line 3,588: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
===Otitis externa=== | |||
==== | ====Otitis externa, Chronic==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,584: | Line 3,601: | ||
</li> | </li> | ||
==== | ====Otitis externa, Fungal==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,594: | Line 3,611: | ||
</li> | </li> | ||
==== | ====Otitis externa, Malignant==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,604: | Line 3,621: | ||
</li> | </li> | ||
==== | ====Otitis externa, Swimmer's ear==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,614: | Line 3,631: | ||
</li> | </li> | ||
====Otitis | ===Otitis media=== | ||
====Otitis media, Acute==== | |||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,624: | Line 3,643: | ||
</li> | </li> | ||
====Otitis | ====Otitis media, Post-intubation==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,634: | Line 3,653: | ||
</li> | </li> | ||
====Otitis | ====Otitis media, Prophylaxis==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,644: | Line 3,663: | ||
</li> | </li> | ||
====Otitis | ====Otitis media, Treatment failure==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,654: | Line 3,673: | ||
</li> | </li> | ||
=== | ===Parotitis=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,663: | Line 3,682: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
==== | ==Eye== | ||
===Conjunctivitis=== | |||
====Conjunctivitis, Bacterial==== | |||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,674: | Line 3,697: | ||
</li> | </li> | ||
==== | ====Conjunctivitis, Gonococcal==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,684: | Line 3,707: | ||
</li> | </li> | ||
==== | ====Conjunctivitis, Inclusion==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,694: | Line 3,717: | ||
</li> | </li> | ||
==== | ====Conjunctivitis, Newborn==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,704: | Line 3,727: | ||
</li> | </li> | ||
==== | ====Conjunctivitis, Viral==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,714: | Line 3,737: | ||
</li> | </li> | ||
==== | ====Conjunctivitis, Trachoma==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,724: | Line 3,747: | ||
</li> | </li> | ||
==== | ===Keratitis=== | ||
====Keratitis, Bacterial==== | |||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,734: | Line 3,759: | ||
</li> | </li> | ||
==== | ====Keratitis, Fungal==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,744: | Line 3,769: | ||
</li> | </li> | ||
==== | ====Keratitis, Mycobacterial==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,754: | Line 3,779: | ||
</li> | </li> | ||
==== | ====Keratitis, Protozoal==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,764: | Line 3,789: | ||
</li> | </li> | ||
==== | ====Keratitis, Viral==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,774: | Line 3,799: | ||
</li> | </li> | ||
=== | ===Endophthalmitis=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,784: | Line 3,809: | ||
</li> | </li> | ||
==== | ====Endophthalmitis, Fungal==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,794: | Line 3,819: | ||
</li> | </li> | ||
==== | ====Endophthalmitis, Hematogenous==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,804: | Line 3,829: | ||
</li> | </li> | ||
==== | ====Endophthalmitis, Post-cataract surgery==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,814: | Line 3,839: | ||
</li> | </li> | ||
==== | ====Endophthalmitis, Post-filtering blebs==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,824: | Line 3,849: | ||
</li> | </li> | ||
==== | ====Endophthalmitis, Post-tramatic==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,834: | Line 3,859: | ||
</li> | </li> | ||
=== | ===Blepharitis=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,844: | Line 3,869: | ||
</li> | </li> | ||
=== | ===Hordeolum=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,854: | Line 3,879: | ||
</li> | </li> | ||
=== | ===Stye=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,864: | Line 3,889: | ||
</li> | </li> | ||
=== | ===Canaliculitis=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,874: | Line 3,899: | ||
</li> | </li> | ||
=== | ===Dacryocystitis=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,884: | Line 3,909: | ||
</li> | </li> | ||
=== | ===Orbital cellulitis=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,894: | Line 3,919: | ||
</li> | </li> | ||
==== | ===Retinitis=== | ||
====Retinitis, Acute retinal necrosis==== | |||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,903: | Line 3,930: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
==== | ====Retinitis, Cytomegalovirus==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,914: | Line 3,941: | ||
</li> | </li> | ||
==== | ==Central nervous system== | ||
===Brain abscess=== | |||
====Brain abscess, Bacterial==== | |||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,924: | Line 3,956: | ||
</li> | </li> | ||
==== | ====Brain abscess, Nocardia==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,934: | Line 3,966: | ||
</li> | </li> | ||
==== | ====Brain abscess, Post-traumatic==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,944: | Line 3,976: | ||
</li> | </li> | ||
==== | ====Brain abscess, Post-surgical==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,953: | Line 3,985: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
=== | ===Encephalitis=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,964: | Line 3,996: | ||
</li> | </li> | ||
=== | ===Epidural abscess=== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,974: | Line 4,006: | ||
</li> | </li> | ||
==== | ===Lyme neuroborreliosis=== | ||
====Lyme neuroborreliosis, Facial nerve palsy==== | |||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,984: | Line 4,019: | ||
</li> | </li> | ||
==== | ====Lyme neuroborreliosis, Meningitis==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 3,994: | Line 4,029: | ||
</li> | </li> | ||
==== | ====Lyme neuroborreliosis, Encephalitis==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,004: | Line 4,039: | ||
</li> | </li> | ||
==== | ====Lyme neuroborreliosis, Post-Lyme disease syndrome==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,013: | Line 4,048: | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration | ||
</li> | </li> | ||
===Meningitis=== | |||
==== | ====Meningitis, Preterm to age 1 month==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,024: | Line 4,061: | ||
</li> | </li> | ||
==== | ====Meningitis, Age 1 month to 50 years==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,034: | Line 4,071: | ||
</li> | </li> | ||
==== | ====Meningitis, Age > 50 years==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,044: | Line 4,081: | ||
</li> | </li> | ||
==== | ====Meningitis, Positive Gram-stain==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,054: | Line 4,091: | ||
</li> | </li> | ||
==== | ====Meningitis, Post-basilar skull fracture==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,064: | Line 4,101: | ||
</li> | </li> | ||
==== | ====Meningitis, Post-trauma==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,074: | Line 4,111: | ||
</li> | </li> | ||
==== | ====Meningitis, Prophylaxis, post-exposure==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,084: | Line 4,121: | ||
</li> | </li> | ||
==== | ====Meningitis, Shunt-related==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,094: | Line 4,131: | ||
</li> | </li> | ||
==== | ====Meningitis, Post-neurosurgery==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,104: | Line 4,141: | ||
</li> | </li> | ||
==== | ====Meningitis, Escherichia coli==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,114: | Line 4,151: | ||
</li> | </li> | ||
==== | ====Meningitis, Haemophilus Influenza==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,124: | Line 4,161: | ||
</li> | </li> | ||
==== | ====Meningitis, Listeria monocytogenes==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,134: | Line 4,171: | ||
</li> | </li> | ||
==== | ====Meningitis, Lyme disease==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,144: | Line 4,181: | ||
</li> | </li> | ||
==== | ====Meningitis, Neisseria meningitidis==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,154: | Line 4,191: | ||
</li> | </li> | ||
==== | ====Meningitis, Streptococcus pneumoniae==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,164: | Line 4,201: | ||
</li> | </li> | ||
====Meningitis, Gram-negative==== | |||
====Meningitis, Gram-negative==== | |||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
* '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | * '''[[Drug]]''' DosageRouteFrequencyDuration {{or}} '''[[Drug]]''' DosageRouteFrequencyDuration {{and}} | ||
| Line 4,404: | Line 4,211: | ||
</li> | </li> | ||
==Lymphatic system== | |||
===Lymphadenitis=== | |||
====Lymphadenitis, Cat scratch==== | ====Lymphadenitis, Cat scratch==== | ||
{{Rx|Preferred Regimen}} | {{Rx|Preferred Regimen}} | ||
Latest revision as of 08:04, 10 May 2015
Musculoskeletal
Osteomyelitis
Candidal osteomyelitis
- Fluconazole 400 mg (6 mg/kg) IV/po daily OR Lipid-based Amphotericin B 3-5 mg/kg daily for two weeks, followed by Fluconazole
- Caspofungin 70 mg loading dose, then 50 mg/day IV OR Micafungin 100 mg/day IV or Anidulafungin 200 mg IV loading dose, then 100 mg/day IV
Chronic osteomyelitis
- Systemic antibiotics per culture and susceptibility results AND
- Surgical debridement
Contiguous with vascular insufficiency
- Systemic antibiotics per culture and susceptibility results AND
- Surgical debridement AND
- Revascularization if possible
Contiguous without vascular insufficiency
- Vancomycin 1 gm IV q12h AND
- Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h
- Linezolid 600 mg po/IV bid AND
- Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h
- Ciprofloxacin 750 mg po bid OR Linezolid 600 mg po/IV bid
- Vancomycin 15-20 mg/kg IV q8-12h targeting trough concentrations of 15-20 mg/L
- Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po once daily if susceptible AND
- Rifampin 300-450 mg po bid OR Rifampin 600 mg po once daily if susceptible
Diabetic foot
- Levofloxacin 750 mg IV/PO q24h OR Cefoxitin 1 g IV q4h (or 2 g IV q6–8h) OR Ceftriaxone 1–2 g/day IV/IM q12–24h OR Ampicillin-Sulbactam 1.5–3 g IV/IM q6h OR Moxifloxacin 400 mg IV/PO q24h OR Ertapenem 1 g IV/IM q24h OR Tigecycline 100 mg IV, then 50 mg IV q12h OR Imipenem-Cilastatin 0.5–1 g IV q6–8h
- Levofloxacin 750 mg IV/PO q24h OR Cefoxitin 1 g IV q4h (or 2 g IV q6–8h) OR Ceftriaxone 1–2 g/day IV/IM q12–24h OR Ampicillin-Sulbactam 1.5–3 g IV/IM q6h OR Moxifloxacin 400 mg IV/PO q24h OR Ertapenem 1 g IV/IM q24h OR Tigecycline 100 mg IV, then 50 mg IV q12h OR Imipenem-Cilastatin 0.5–1 g IV q6–8h
- Linezolid 600 mg IV/PO q12h OR Daptomycin 4 mg/kg IV q24h OR Vancomycin 15–20 mg/kg IV q8–12h (trough: 10–20 mg/L)
- Piperacillin–Tazobactam 3.375 g IV q6–8h
- (Vancomycin 15–20 mg/kg IV q8–12h OR Linezolid 600 mg IV/PO q12h OR Daptomycin 4 mg/kg IV q24h) AND
- (Piperacillin–Tazobactam 3.375 g IV q6–8h OR Imipenem-Cilastatin 0.5–1 g IV q6–8h OR Ertapenem 1 g IV/IM q24h OR Meropenem 1 g IV/IM q24h) OR (Metronidazole 15 mg/kg IV, then 7.5 mg/kg IV q6h PLUS Ceftazidime 2 g IV q8h OR Cefepime 2 g IV q8h OR Aztreonam 2 g IV q6–8h)
Foot bone
- Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h
- Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q8h OR Meropenem 1 gm IV q8h
Foot puncture wound
- Cleanse wound AND
- Tetanus booster if due AND
- X-ray to exclude presence of radio-opaque foreign body
Hematogenous
- MRSA likely – Vancomycin 15–20 mg/kg IV q8–12h AND (Ceftriaxone 1–2 g/day IV/IM q12–24h OR Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h)
- MRSA unlikely – (Nafcillin OR Oxacillin) AND (Ceftriaxone 1–2 g/day IV/IM q12–24h OR Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h)
- Linezolid 600 mg po/IV bid OR Daptomycin 4 mg/kg IV q24h to replace vancomycin
- Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg IV/PO q24h OR Aztreonam 2 g IV q6–8h to replace a third-generation cephalosporin
Hemoglobinopathy
- Ciprofloxacin 400 mg IV q12h OR Ceftriaxone 2 gm IV q24h
- Ciprofloxacin 750 mg po bid for 6 weeks OR Levofloxacin 750 mg po q24h for 6 weeks
Prosthetic joint infection
- (Nafcillin 2 gm IV q4h OR Oxacillin 2 gm IV q4h IV) PLUS Rifampin 300 mg po bid
OR - Cefazolin 2 gm IV q8h PLUS Rifampin 300 mg po bid for 2-6 weeks followed by (Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h) PLUS Rifampin 300 mg po bid for 3-6 months
- Vancomycin 15-20 mg/kg IV q8-12h PLUS Rifampin 300 mg po bid for 2-6 weeks followed by (Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h) PLUS Rifampin 300 mg po bid for 3-6 months
- Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
- Penicillin-susceptible – Ampicillin 12 gm IV OR Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks
- Penicillin-resistant – Vancomycin 15 mg/kg IV q12h x 4-6 week
- Penicillin G 20 million units IV continuous infusion or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
- Ertapenem 1 gm q24h IV OR Ceftriaxone 2 gm IV q24h OR Cefepime 2 gm IV q12h for 4-6 weeks
- Cefepime 2 gm IV q12h OR Meropenem 1 gm IV q8h for 4-6 weeks AND
- Tobramycin 5.1 mg/kg once daily IV for 4-6 weeks
Spinal implant
- (Nafcillin 2 gm IV q4h OR Oxacillin 2 gm IV q4h IV) PLUS Rifampin 300 mg po bid
OR - Cefazolin 2 gm IV q8h PLUS Rifampin 300 mg po bid for 2-6 weeks followed by (Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h) PLUS Rifampin 300 mg po bid for 3-6 months
- Vancomycin 15-20 mg/kg IV q8-12h PLUS Rifampin 300 mg po bid for 2-6 weeks followed by (Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h) PLUS Rifampin 300 mg po bid for 3-6 months
- Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
- Penicillin-susceptible – Ampicillin 12 gm IV OR Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks
- Penicillin-resistant – Vancomycin 15 mg/kg IV q12h x 4-6 week
- Penicillin G 20 million units IV continuous infusion or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
- Ertapenem 1 gm q24h IV OR Ceftriaxone 2 gm IV q24h OR Cefepime 2 gm IV q12h for 4-6 weeks
- Cefepime 2 gm IV q12h OR Meropenem 1 gm IV q8h for 4-6 weeks AND
- Tobramycin 5.1 mg/kg once daily IV for 4-6 weeks
Sternal
- Vancomycin 15-30 mg/kg IV q 8-12h targeting trough of 15-20 μg/mL OR Nafcillin 2 gm IV q4h
- Linezolid 600 mg IV/po bid