Sandbox g15: Difference between revisions
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* Neonates (postnatal age ≤ 7 days): 50 mg/kg/24 hr IV or IM q 12 hr (≤ 2,000 g); 75 mg/kg/24 hr divided q 8 hr IV or IM (> 2,000 g) | * Neonates (postnatal age ≤ 7 days): 50 mg/kg/24 hr IV or IM q 12 hr (≤ 2,000 g); 75 mg/kg/24 hr divided q 8 hr IV or IM (> 2,000 g) | ||
* Neonates (postnatal age > 7 days): 50 mg/kg/24 hr IV or IM q 12 hr (< 1,200 g); 75 mg/ kg/24 hr divided q 8 hr IV or IM (1,200–2,000 g); 100 mg/kg/24 hr divided q 6 hr IV or IM (> 2,000 g) | * Neonates (postnatal age > 7 days): 50 mg/kg/24 hr IV or IM q 12 hr (< 1,200 g); 75 mg/kg/24 hr divided q 8 hr IV or IM (1,200–2,000 g); 100 mg/kg/24 hr divided q 6 hr IV or IM (> 2,000 g) | ||
* Children: 100-200 mg/kg/24 hr divided q 6 hr IV or IM | * Children: 100-200 mg/kg/24 hr divided q 6 hr IV or IM | ||
* Adults: 250-500 mg q 4-8 hr IV or IM | * Adults: 250-500 mg q 4-8 hr IV or IM | ||
Line 142: | Line 142: | ||
* Rash | * Rash | ||
* Eosinophilia | * Eosinophilia | ||
* Serum sickness | * Serum sickness-like reaction | ||
|- | |- | ||
| '''Cefadroxil''' | | '''Cefadroxil''' | ||
Line 643: | Line 643: | ||
* Anaerobes | * Anaerobes | ||
| | | | ||
* Neonates (postnatal age ≤ 7 days): 7.5 mg/kg 48 hr PO or IV (< 1,200 g); 7.5 mg/kg/24 hr q 24 hr PO or IV (1,200–2,000 g); 15 mg/ kg/24 hr divided q 12 hr PO or IV (> 2,000 g) | * Neonates (postnatal age ≤ 7 days): 7.5 mg/kg 48 hr PO or IV (< 1,200 g); 7.5 mg/kg/24 hr q 24 hr PO or IV (1,200–2,000 g); 15 mg/kg/24 hr divided q 12 hr PO or IV (> 2,000 g) | ||
* Neonates (postnatal age > 7 days): 5 mg/kg/24 hr divided q 12 hr PO or IV (< 2,000 g); 30 mg/kg/24 hr divided q 12 hr PO or IV (> 2,000 g) | * Neonates (postnatal age > 7 days): 5 mg/kg/24 hr divided q 12 hr PO or IV (< 2,000 g); 30 mg/kg/24 hr divided q 12 hr PO or IV (> 2,000 g) | ||
* Children: 30 mg/kg/24 hr divided q 6-8 hr PO or IV | * Children: 30 mg/kg/24 hr divided q 6-8 hr PO or IV | ||
Line 751: | Line 751: | ||
* Dizziness | * Dizziness | ||
|- | |- | ||
| '''Oxacillin''' | |||
| | | | ||
* S. aureus and other gram-positive cocci except Enterococcus and coagulase-negative staphylococci | |||
| | | | ||
* Neonates (postnatal age ≤ 7 days): 50 mg/kg/24 hr divided q 12 hr IV (< 2,000 g); 75 mg/kg/24 hr IV divided q 8 hr IV (> 2,000 g) | |||
* Neonates (postnatal age > 7 days): 50 mg/kg/24 hr IV divided q 12 hr IV (< 1,200 g); 75 mg/kg/24 hr divided q 8 hr IV (1,200–2,000 g); 100 mg/kg/24 hr IV divided q 6 hr IV (> 2,000 g) | |||
Neonates | * Infants: 100-200 mg/kg/24 hr divided q 4-6 hr IV | ||
* Children: PO 50-100 mg/kg/24 hr divided q 4-6 hr IV | |||
100 mg/kg/24 hr IV divided q 6 hr IV | * Adults: 2-12 g/24 hr divided q 4-6 hr IV (max dose: 12 g/24 hr) | ||
Infants: 100-200 mg/kg/24 hr divided q 4-6 hr IV | |||
Adults: 2-12 g/24 hr divided q 4-6 hr IV (max dose: 12 g/24 hr) | |||
| | | | ||
* Rash | |||
* Eosinophilia | |||
* Neutropenia | |||
|- | |- | ||
| '''Penicillin G''' | |||
| | | | ||
* S. pneumoniae | |||
* Group A Streptococcus | |||
* N. gonorrhoeae | |||
* N. meningitidis | |||
| | | | ||
* Neonates (postnatal age ≤ 7 days): 50,000 units/kg/24 hr divided q 12 hr IV or IM (< 2,000 g); 75,000 units/kg/24 hr divided q 8 hr IV or IM (> 2,000 g) | |||
* Neonates (postnatal age > 7 days): 50,000 units/kg/24 hr divided q 12 hr IV (< 1,200 g); 75,000 units/kg/24 hr q 8 hr IV (1,200–2,000 g); 100,000 units/kg/24 hr divided q 6 hr IV (> 2,000 g) | |||
* Children: 100,000-250,000 units/kg/24 hr divided q 4-6 hr IV or IM (max dose: 400,000 units/kg/24 hr) | |||
* Adults: 2-24 million units/24 hr divided q 4-6 hr IV or IM | |||
Children: 100,000-250,000 units/kg/24 hr divided q 4-6 hr IV or IM (max dose: 400,000 units/kg/24 hr) | |||
Adults: 2-24 million units/24 hr divided q 4-6 hr IV or IM | |||
| | | | ||
* Rash | |||
* Eosinophilia | |||
* Allergy | |||
* Seizures | |||
|- | |- | ||
| '''Penicillin G, benzathine''' | |||
| | | | ||
* Group A Streptococcus | |||
| | | | ||
* Neonates: 50,000 units/kg IM once | |||
* Children: 300,000-1.2 million units/kg q 3-4 wk IM (max dose: 1.2-2.4 million units/dose) | |||
Neonates | * Adults: 1.2 million units IM q 3-4 wk | ||
Children: 300,000-1.2 million units/kg q 3-4 wk IM (max dose: | |||
1.2-2.4 million units/dose) | |||
Adults: 1.2 million units IM q 3-4 wk | |||
| | | | ||
* Rash | |||
* Eosinophilia | |||
* Allergy | |||
|- | |- | ||
| '''Penicillin G, procaine''' | |||
| | | | ||
* Gram-positive pathogens | |||
| | | | ||
* Neonates: 50,000 units/kg/24 hr IM | |||
* Children: 25,000-50,000 units/kg/24 hr IM for 10 days (max dose: 4.8 million units/dose) | |||
Neonates | * Adults: 0.6-4.8 million units q 12-24 hr IM | ||
Children: 25,000-50,000 units/kg/24 hr IM for 10 days (max dose: | |||
4.8 million units/dose) | |||
Adults: 0.6-4.8 million units q 12-24 hr IM | |||
| | | | ||
* Rash | |||
* Eosinophilia | |||
* Allergy | |||
|- | |- | ||
| '''Penicillin V''' | |||
| | | | ||
* S. pneumoniae | |||
* N. gonorrhoeae | |||
* N. meningitidis | |||
| | | | ||
* Children: 25-50 mg/kg/24 hr divided q 4-8 hr PO | |||
* Adults: 125-500 mg q 6-8 hr PO (max dose: 3 g/24 hr) | |||
Children: 25-50 mg/kg/24 hr divided q 4-8 hr PO | |||
| | | | ||
* Rash | |||
* Eosinophilia | |||
* Allergy | |||
|- | |- | ||
| '''Piperacillin''' | |||
| | | | ||
* E. coli | |||
* Enterobacter | |||
* Serratia | |||
* P. aeruginosa | |||
* Bacteroides | |||
| | | | ||
* Neonates (postnatal age ≤ 7 days): 150 mg/kg/24 hr divided q 8-12 hr IV | |||
* Neonates (postnatal age > 7 days): 200 mg/kg divided q 6-8 hr IV | |||
Neonates | * Children: 200-300 mg/kg/24 hr divided q 4-6 hr IV | ||
* Adults: 2-4 g/dose q 4-6 hr (max dose: 24 g/24 hr) IV | |||
Children: 200-300 mg/kg/24 hr divided q 4-6 hr IV | |||
Adults: 2-4 g/dose q 4-6 hr (max dose: 24 g/24 hr) IV | |||
| | | | ||
* Rash | |||
* Eosinophilia | |||
* Serum sickness-like reaction | |||
|- | |- | ||
| '''Piperacillin-Tazobactam''' | |||
| | | | ||
* S. aureus | |||
* H. influenzae | |||
* E. coli | |||
* Enterobacter | |||
* Serratia | |||
* Acinetobacter | |||
* P. aeruginosa | |||
* Bacteroides | |||
| | | | ||
* Children: 300-400 mg/kg/24 hr divided q 6-8 hr IV or IM | |||
* Adults: 3.375 g q 6-8 hr IV or IM | |||
Children: 300-400 mg/kg/24 hr divided q 6-8 hr IV or IM | |||
| | | | ||
* Rash | |||
* Eosinophilia | |||
|- | |- | ||
| '''Quinupristin-Dalfopristin''' | |||
| | | | ||
* E. faecium, vancomycin-resistant | |||
* S. aureus, methicillin-resistant | |||
| | | | ||
* Children and adults: 7.5 mg/kg q 8 hr IV | |||
Children and adults | |||
| | | | ||
* Pain | |||
* Edema | |||
* Phlebitis | |||
* Nausea | |||
* Diarrhea | |||
|- | |- | ||
| '''Sulfadiazine''' | |||
| | | | ||
* E. coli | |||
* P. mirabilis | |||
* Klebsiella | |||
| | | | ||
* Neonates: 100 mg/kg/24 hr divided q 12 hr PO with pyrimethamine 1 mg/kg/24 hr PO with folinic acid | |||
* Children: 120-200 mg/kg/24 hr divided q 6 hr PO with pyrimethamine 2 mg/kg/24 hr divided q 12 hr PO ≥3 days then 1 mg/kg/24 hr (max dose: 25 mg/24 hr) with folinic acid | |||
Neonates: 100 mg/kg/24 hr divided q 12 hr PO with pyrimethamine 1 mg/kg/24 hr PO | |||
Children: 120-200 mg/kg/24 hr divided q 6 hr PO with pyrimethamine 2 mg/kg/24 hr divided q 12 hr PO ≥3 days then 1 mg/kg/24 hr (max dose: 25 mg/24 hr) with folinic acid | |||
| | | | ||
* Rash | |||
* Stevens-Johnson syndrome | |||
* Nausea | |||
* Leukopenia | |||
* Crystalluria | |||
|- | |- | ||
| '''Sulfamethoxazole''' | |||
| | | | ||
* Bacteria associated with otitis media, chronic bronchitis, and lower urinary tract infections | |||
| | | | ||
* Children: 50-60 mg/kg/24 hr divided q 12 hr PO | |||
* Adults: 1 g/dose q 12 hr PO (max dose: 3 g/24 hr) | |||
Children: 50-60 mg/kg/24 hr divided q 12 hr PO | |||
| | | | ||
* Rash | |||
* Stevens-Johnson syndrome | |||
* Nausea | |||
* Leukopenia | |||
* Crystalluria | |||
|- | |- | ||
| '''Sulfisoxazole''' | |||
| | | | ||
* Bacteria associated with otitis media, chronic bronchitis, and lower urinary tract infections | |||
| | | | ||
* Children: 120-150 mg/kg/24 hr divided q 4-6 hr PO (max dose: 6 g/24 hr) | |||
* Adults: 4-8 g/24 hr divided q 4-6 hr PO | |||
Children: 120-150 mg/kg/24 hr divided q 4-6 hr PO (max dose: 6 g/24 hr) | |||
Adults: 4-8 g/24 hr divided q 4-6 hr PO | |||
| | | | ||
* Rash | |||
* Stevens-Johnson syndrome | |||
* Nausea | |||
* Leukopenia | |||
* Crystalluria | |||
|- | |- | ||
| '''Ticarcillin''' | |||
| | | | ||
* E. coli | |||
* Enterobacter | |||
* Serratia | |||
* P. aeruginosa | |||
* Bacteroides | |||
| | | | ||
* Neonates (postnatal age ≤ 7 days): 150 mg/kg/24 hr divided q 8-12 hr IV | |||
* Neonates (postnatal age > 7 days): 150 mg/kg/24 hr divided q 8-12 hr IV (< 1,200 g); 150 mg/kg/24 hr divided q 12 hr IV (1,200–2,000 g); 300 mg/kg/24 hr divided q 6-8 hr IV (> 2,000 g) | |||
Neonates | * Children: 200-400 mg/kg/24 hr divided q 4-6 hr IV | ||
* Adults: 2-4 g/dose q 4-6 hr IV (max dose: 24 g/24 hr) | |||
Children: 200-400 mg/kg/24 hr divided q 4-6 hr IV | |||
Adults: 2-4 g/dose q 4-6 hr IV (max dose: 24 g/24 hr) | |||
| | | | ||
* Rash | |||
* Eosinophilia | |||
* Liver transaminases elevation | |||
|- | |- | ||
| '''Ticarcillin-Clavulanate''' | |||
| | | | ||
* S. aureus | |||
* H. influenzae | |||
* Enterobacter | |||
* E. coli | |||
* Serratia | |||
* P. aeruginosa | |||
* Acinetobacter | |||
* Bacteroides | |||
| | | | ||
* Children: 280-400 mg/kg/24 hr q 4-8 hr IV or IM | |||
* Adults: 3.1 g q 4-8 hr IV or IM (max dose: 18-24 g/24 hr) | |||
Children: 280-400 mg/kg/24 hr q 4-8 hr IV or IM | |||
Adults: 3.1 g q 4-8 hr IV or IM (max dose: 18-24 g/24 hr) | |||
| | | | ||
* Rash | |||
* Eosinophilia | |||
* Liver transaminases elevation | |||
|- | |- | ||
| '''Tigecycline''' | |||
| | | | ||
* Enterobacteriaceae including ESBL producers | |||
* Streptococcus | |||
* Staphylococcus | |||
* Anaerobes | |||
| | | | ||
* Adults: 100 mg loading dose followed by 50 mg q 12 hr IV | |||
Adults: 100 mg loading dose followed by 50 mg q 12 hr IV | |||
| | | | ||
* Photosensitivity | |||
* Hypersensitivity | |||
* Hepatic impairment | |||
|- | |- | ||
| '''Tobramycin''' | |||
| | | | ||
* E. coli | |||
* Klebsiella | |||
* Enterobacter | |||
* Serratia | |||
* Proteus | |||
* Pseudomonas | |||
| | | | ||
* Neonates (postnatal age ≤ 7 days): 2.5 mg/kg q12-18 hr IV or IM (< 2,000 g); 2.5 mg/kg q 12 hr IV or IM (> 2,000 g) | |||
* Neonates (postnatal age > 7 days): 2.5 mg/kg q 8-12 hr IV or IM (< 2,000 g); 2.5 mg/kg q 8 hr IV or IM (> 2,000 g) | |||
Neonates | * Children: 2.5 mg/kg/24 hr divided q 8-12 hr IV or IM; 5-7.5 mg/kg/24 hr IV | ||
* Adults: 3-6 mg/kg/24 hr divided q 8 hr IV or IM | |||
Children: 2.5 mg/kg/24 hr divided q 8-12 hr IV or IM | |||
Adults: 3-6 mg/kg/24 hr divided q 8 hr IV or IM | |||
| | | | ||
* Ototoxicity | |||
* Nephrotoxicity | |||
|- | |- | ||
| '''Trimethoprim''' | |||
| | | | ||
* E. coli | |||
* Klebsiella | |||
* P. mirabilis | |||
* Enterobacter | |||
* P. jirovecii | |||
| | | | ||
* Children (< 12 yr): 4-6 mg/kg/24 hr divided q 12 hr PO | |||
* Children (> 12 yr) and adults: 100-200 mg q 12 hr PO | |||
Children | |||
| | | | ||
* Megaloblastic anemia | |||
* Bone marrow suppression | |||
* Nausea | |||
* Epigastric distress | |||
* Rash | |||
|- | |- | ||
| '''Vancomycin''' | |||
| | | | ||
* Gram-positive pathogens including Staphylococcus, S. pneumoniae, and Enterococcus | |||
* C. difficile | |||
| | | | ||
* Neonates (postnatal age > 7 days): 15 mg/kg/24 hr divided q 24 hr IV (< 1,200 g); 15 mg/kg/24 hr divided q 12-18 hr IV (1,200–2,000 g); 30 mg/kg/24 hr divided q 12 hr IV (> 2,000 g) | |||
* Neonates (postnatal age > 7 days): 15 mg/kg/24 hr divided q 24 hr IV (< 1,200 g); 15 mg/kg/24 hr divided q 8-12 hr IV (1,200–2,000 g); 45 mg/kg/24 hr divided q 8 hr IV (> 2,000 g) | |||
* Children: 45-60 mg/kg/24 hr divided q 8-12 hr IV | |||
* C. difficile–associated colitis: 40-50 mg/kg/24 hr divided q 6-8 hr PO; 40-50 mg/kg/24 hr divided q 6-8 hr PO | |||
days | |||
15 mg/kg/24 hr divided q 8-12 hr IV | |||
divided q 8 hr IV | |||
Children: 45-60 mg/kg/24 hr divided q 8-12 hr IV | |||
40-50 mg/kg/24 hr divided q 6-8 hr PO | |||
| | | | ||
* Ototoxicity | |||
* Nephrotoxicity | |||
|} | |} |
Latest revision as of 07:03, 3 June 2015
Antibiotic Agent | Antimicrobial Spectrum | Dosing Information | Notable Adverse Reaction |
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Amikacin |
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Amoxicillin |
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Amoxicillin-Clavulanate |
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Ampicillin |
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Ampicillin-Sulbactam |
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Azithromycin |
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Aztreonam |
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Carbenicillin |
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Cefaclor |
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Cefadroxil |
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Cefazolin |
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Cefdinir |
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Cefepime |
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Cefixime |
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Cefoperazone |
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Cefotaxime |
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Cefotetan |
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Cefoxitin |
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Cefpodoxime |
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Cefprozil |
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Ceftazidime |
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Ceftiaoxime |
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Ceftriaxone |
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Cefuroxime |
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Cephalexin |
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Cephradine |
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Chloramphenicol |
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Ciprofloxacin |
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Clarithromycin |
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Clindamycin |
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Cloxacillin |
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Trimethoprim-Sulfamethoxazole |
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Demeclocycline |
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Dicloxacillin |
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Doripenem |
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Doxycycline |
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Erythromycin |
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Gentamicin |
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Imipenem-Cilastatin |
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Linezolid |
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Loracarbef |
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Meropenem |
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Metronidazole |
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Mezlocillin |
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Mupirocin |
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Nafcillin |
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Nalidixic acid |
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Neomycin |
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Nitrofurantoin |
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Ofloxacin |
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Oxacillin |
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Penicillin G |
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Penicillin G, benzathine |
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Penicillin G, procaine |
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Penicillin V |
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Piperacillin |
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Piperacillin-Tazobactam |
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Quinupristin-Dalfopristin |
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Sulfadiazine |
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Sulfamethoxazole |
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Sulfisoxazole |
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Ticarcillin |
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Ticarcillin-Clavulanate |
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Tigecycline |
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Tobramycin |
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Trimethoprim |
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Vancomycin |
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